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Photosensitivity

By

Julia Benedetti

, MD, Harvard Medical School

Last full review/revision Sep 2019| Content last modified Sep 2019
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Photosensitivity is a cutaneous overreaction to sunlight. It may be idiopathic or occur after exposure to certain toxic or allergenic drugs or chemicals, and it is sometimes a feature of systemic disorders (eg, systemic lupus erythematosus, porphyria, pellagra, xeroderma pigmentosum). Diagnosis is clinical. Treatment varies by type.

In addition to the acute effects of sunlight Sunburn Sunburn is characterized by erythema and sometimes pain and blisters caused by overexposure to solar ultraviolet radiation. Treatment is similar to that for thermal burns, including cool compresses... read more Sunburn and the chronic effects of sunlight Chronic Effects of Sunlight Chronic affects of sunlight include photoaging, actinic keratoses, and skin cancer. (See also Overview of Effects of Sunlight.) Chronic exposure to sunlight ages the skin (photoaging, dermatoheliosis... read more Chronic Effects of Sunlight , a variety of less common reactions may occur after sun exposure. Unless the cause is obvious, patients with pronounced photosensitivity should be evaluated for systemic or cutaneous disorders associated with light sensitivity such as systemic lupus erythematosus (SLE) Systemic Lupus Erythematosus (SLE) Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. Common manifestations may include arthralgias and... read more Systemic Lupus Erythematosus (SLE) , dermatomyositis Autoimmune Myositis Autoimmune myositis is characterized by inflammatory and degenerative changes in the muscles (polymyositis) or in the skin and muscles (dermatomyositis). Manifestations include symmetric weakness... read more Autoimmune Myositis , and porphyria Overview of Cutaneous Porphyrias Cutaneous porphyrias result from deficiency (and in one case, excess) of certain enzymes in the heme biosynthetic pathway (see table Substrates and Enzymes of the Heme Biosynthetic Pathway)... read more .

Solar urticaria

In certain patients, urticaria develops at a site of sun exposure within a few minutes. Lesions generally resolve within 24 hours. Rarely, if large areas are involved, syncope, dizziness, wheezing, and other systemic symptoms may develop. Etiology is unclear but may involve endogenous skin constituents functioning as photoallergens, leading to mast cell degranulation as in other types of urticaria. Solar urticaria can be distinguished from other types of urticaria in that wheals in solar urticaria occur only on exposed skin after ultraviolet (UV) light exposure.

Solar urticaria can be classified based on the component of the UV spectrum (UVA, UVB, and visible light) that causes lesions. If necessary, patients can be tested by exposing part of the skin to natural light or artificial light at particular wavelengths (phototesting).

Treatment of solar urticaria can be difficult and may include H1 blockers, topical corticosteroids, and sunscreens. If standard treatment fails, desensitization with narrow-band UVB or PUVA (psoralen plus ultraviolet A), may be tried. Omalizumab (anti-IgE therapy) has been successful in a small number of patients. The disorder is chronic and can wax and wane over years.

Chemical photosensitivity

Over 100 substances, ingested or applied topically, are known to predispose to cutaneous reactions after sun exposure. A limited number are responsible for most reactions (see Table: Some Substances That Cause Cutaneous Photosensitivity Some Substances That Cause Cutaneous Photosensitivity Photosensitivity is a cutaneous overreaction to sunlight. It may be idiopathic or occur after exposure to certain toxic or allergenic drugs or chemicals, and it is sometimes a feature of systemic... read more Some Substances That Cause Cutaneous Photosensitivity ). Reactions are divided into phototoxicity and photoallergy. Phototesting can help confirm the diagnosis. Treatment for chemical photosensitivity is topical corticosteroids and avoidance of the causative substance.

In phototoxicity, light-absorbing compounds directly generate free radicals and inflammatory mediators, causing tissue damage manifesting as pain and erythema (like sunburn Sunburn Sunburn is characterized by erythema and sometimes pain and blisters caused by overexposure to solar ultraviolet radiation. Treatment is similar to that for thermal burns, including cool compresses... read more Sunburn ). This reaction does not require prior sun exposure and can appear in any person, although reaction severity is highly variable. Typical causes of phototoxic reactions include topical (eg, perfumes, coal tar, furocoumarin-containing plants [such as limes, celery, and parsley], drugs used for photodynamic therapy) or ingested (eg, tetracyclines, thiazides) agents. Phototoxic reactions do not involve non–sun-exposed skin.

Photoallergy is a type IV (cell-mediated) immune response Overview of Allergic and Atopic Disorders Allergic (including atopic) and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. Inappropriate immune reactions include those that are... read more . Light absorption causes structural changes in the drug or substance, allowing it to bind to tissue protein and function as a hapten, making the complex allergenic. Prior exposure to the allergen is required. The reaction is usually eczematous, with erythema, scaling, pruritus, and sometimes vesicles. Typical causes of photoallergic reactions include aftershave lotions, sunscreens, and sulfonamides. Photoallergy occurs less often than phototoxicity, and the reaction may extend to non–sun-exposed skin.

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Polymorphous light eruption

Polymorphous light eruption is a common photosensitive reaction to UV and sometimes visible light. It does not seem to be associated with systemic disease or drugs. A positive family history in some patients suggests a genetic risk factor.

Eruptions appear on sun-exposed areas, usually 30 minutes to several hours after exposure; however, sometimes eruptions do not appear for up to several days. Lesions are pruritic, erythematous, and often papular but may be papulovesicular or plaquelike. They are more common among women and people from northern climates when first exposed to spring or summer sun than among those exposed to sun year-round. Lesions often subside within several days to weeks.

Diagnosis of polymorphous light eruption is made by history, skin findings, and exclusion of other sun-sensitivity disorders. Diagnosis sometimes requires reproduction of the lesions with phototesting when the patient is not using any potentially photosensitizing drugs.

Often, lesions are self-limited and spontaneously improve as summer progresses. Preventive measures Prevention The skin may respond to sunlight with chronic (eg, dermatoheliosis [photoaging], actinic keratosis) or acute (eg, photosensitivity, sunburn) changes. The sun emits a wide range of electromagnetic... read more include using a broad-spectrum sunscreen and moderating sun exposure. More severely affected patients may benefit from desensitization in early spring by graduated exposure to UV light with low-dose psoralen plus ultraviolet A (PUVA―see Phototherapy Phototherapy Psoriasis is an inflammatory disease that manifests most commonly as well-circumscribed, erythematous papules and plaques covered with silvery scales. Multiple factors contribute, including... read more Phototherapy ) or narrowband UVB (312 nm) phototherapy. Mild to moderate eruptions are treated with topical corticosteroids. Patients with disabling disease may require a course of oral immunosuppressive therapy such as prednisone, azathioprine, cyclosporine, or hydroxychloroquine.

Some evidence suggests that antioxidants such as Polypodium leucotomos, a natural tropical fern extract, may help prevent polymorphous light eruption, but further studies are needed (1) General reference Photosensitivity is a cutaneous overreaction to sunlight. It may be idiopathic or occur after exposure to certain toxic or allergenic drugs or chemicals, and it is sometimes a feature of systemic... read more General reference .

General reference

  • Nestor MS, Berman B, Swenson N: Safety and efficacy of oral Polypodium leucotomos extract in healthy adult subjects.J Clin Aesthet Dermatol 8(2):19–23, 2015.

Drugs Mentioned In This Article

Drug Name Select Trade
PLAQUENIL
LIBRIUM
No US brand name
OTREXUP
IMURAN
SOTRET
CARAC
NEORAL, SANDIMMUNE
GRIFULVIN V
ARALEN
DTIC-DOME
RAYOS
LASIX
CORDARONE
XOLAIR
NEXCEDE
XANAX
FELDENE
QUALAQUIN
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