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Ambulatory pH Monitoring

By

Jonathan Gotfried

, MD, Lewis Katz School of Medicine at Temple University

Last full review/revision Jun 2019| Content last modified Jun 2019
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Ambulatory 24-hour esophageal pH monitoring with or without intraluminal impedance testing is currently the most common test for quantifying gastroesophageal reflux (1). The principal indications are

  • To document excessive acid or nonacid reflux

  • To correlate symptoms with reflux episodes

  • To identify candidates for antireflux surgery

  • To evaluate the effectiveness of medical or surgical treatments

Ambulatory pH monitoring can be done when the patient is on or off proton pump inhibitor (PPI) therapy. When the test is done off therapy, the diagnosis of gastroesophageal reflux disease can be confirmed or excluded. If monitoring is done off therapy and no acidic pH is found in the stomach, the diagnosis of achlorhydria is confirmed. Monitoring on therapy can determine the adequacy of gastric acid suppression and the presence of esophageal acid exposure in patients who have been referred for testing because PPI therapy failed.

Tests may use a transnasal continuous reflux-monitoring catheter or a wireless pH-monitoring device that is endoscopically attached to the distal esophagus.

Complications are very rare. Patients must have nothing by mouth (npo) after midnight but are free to eat as usual after the monitoring device is placed.

General reference

  • 1. Hobbs P, Gyawali CP: The role of esophageal pH-impedance testing in clinical practice. Curr Opin Gastroenterol 34(4):249–257, 2018. doi: 10.1097/MOG.0000000000000441.

Catheter-based pH monitoring

A thin tube containing a pH probe is positioned 5 cm above the lower esophageal sphincter. The patient records symptoms, meals, and sleep for 24 hours. Esophageal acid exposure is defined by the percentage of the total recording time that the pH is < 4.0. A value > 4.3% is considered abnormal if the patient has not been taking a proton pump inhibitor, and a value > 1.3% is abnormal if the patient has been taking a proton pump inhibitor for the duration of the test. Additional sensors along the more proximal regions of the pH probe allow identification of proximal reflux episodes.

A dual-channel esophageal and gastric pH probe has two separate pH sensors along the catheter; one sensor is placed 5 cm above the lower esophageal sphincter, and one sensor is placed in the stomach. The two sensors allow for simultaneous measurement of the pH level in the distal esophagus and in the stomach. This test is most useful for evaluating the efficacy and adequacy of acid-suppressing drugs.

The newer combined pH-impedance monitoring devices also do multichannel intraluminal impedance testing, which identifies reflux of any gastric contents into the esophagus regardless of pH level. In addition to acid reflux, this test helps detect weakly acidic reflux (pH between 4.0 and 7) and nonacidic reflux (pH > 7), which would be missed by conventional pH monitoring.

The correlation between patient-reported symptoms and reflux events can be assessed using the symptom index or symptom association probability. A significant symptom index value or symptom association probability value suggests that the correlation between symptoms and reflux events is not due to chance. Excessive reflux and significant symptom-reflux correlation are positive predictors of a favorable outcome from antireflux surgery.

Wireless pH monitoring

Ambulatory esophageal pH monitoring can also be done using a wireless pH-sensing capsule that is attached to the distal esophagus. The device is endoscopically placed 5 cm above the lower esophageal sphincter and continuously monitors esophageal acid exposure (defined as pH < 4.0) for 48 hours. Similar to the probe-based test, patients record symptoms, meals, and sleep for the duration of the test and excessive acid exposure and symptom-reflux correlation (symptom index or symptom association probability) are identified. However, because the capsule is a pure pH sensor, only acid reflux is detected. The capsule usually falls off within a week of placement and is spontaneously passed in the stool. Because the capsule transmits data wirelessly while attached, it does not need to be retrieved.

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