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Overview of Histiocytic Disorders

By

Jeffrey M. Lipton

, MD, PhD, Zucker School of Medicine at Hofstra/Northwell;


Carolyn Fein Levy

, MD, Hofstra Northwell School of Medicine

Last full review/revision Jul 2019
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The histiocytic disorders are clinically heterogeneous disorders that result from an abnormal proliferation of histiocytes that are either

  • Monocyte-macrophages (antigen-processing cells)

  • Dendritic cells (antigen-presenting cells)

Classifying histiocytic disorders is difficult (see table Histiocytic Disorders Histiocytic Disorders The histiocytic disorders are clinically heterogeneous disorders that result from an abnormal proliferation of histiocytes that are either Monocyte-macrophages (antigen-processing cells) Dendritic... read more Histiocytic Disorders ) and has changed over time as an understanding of the biology of these cells has evolved. Langerhans cell histiocytosis Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. Most cases occur in children. Manifestations may include... read more Langerhans Cell Histiocytosis is the most common histiocytic disorder. There are other rare histiocytic disorders such as Erdheim-Chester disease and juvenile xanthogranuloma, some of which are now considered variants of Langerhans cell histiocytosis.

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