Merck Manual

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Thrombocytopenia Due to Splenic Sequestration

By

David J. Kuter

, MD, DPhil, Harvard Medical School

Last full review/revision Jun 2022| Content last modified Sep 2022
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The platelet count usually is > 30,000/mcL (> 30 × 109/L) unless the disorder causing splenomegaly also impairs platelet production (eg, in myelofibrosis with myeloid metaplasia).

Sequestered platelets are released from the spleen at times of stress. Therefore, thrombocytopenia caused only by splenic sequestration rarely causes bleeding.

In patients with normal hepatic function, splenectomy corrects the thrombocytopenia; however, splenectomy is not indicated unless severe thrombocytopenia due to simultaneous bone marrow failure is present.

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