Antiretroviral Dosing for Neonates With Perinatal HIV Exposure

Medication (Oral)*

Low-Risk Prophylaxis (2 Weeks Total Treatment)

High-Risk Therapy (6 Weeks Total Treatment)‡

Zidovudine (ZDV)†Zidovudine (ZDV)†

≥ 35 weeks gestation at birth: ZDV 4 mg/kg twice daily

≥ 35 weeks gestation at birth: ZDV 4 mg/kg twice daily

≥ 30 to < 35 weeks gestation at birth:

• ZDV 2 mg/kg twice daily

≥ 30 to < 35 weeks gestation at birth:

• Birth to age 2 weeks: ZDV 2 mg/kg twice daily

• Age 2–6 weeks: ZDV 3 mg/kg twice daily

< 30 weeks gestation at birth:

• ZDV 2 mg/kg twice daily

< 30 weeks gestation at birth:

• Birth to age 4 weeks: ZDV 2 mg/kg twice daily for 4 weeks

• Age 4–6 weeks: ZDV 3 mg/kg twice daily

Lamivudine (3TC)Lamivudine (3TC)

Not applicable

≥ 32 weeks gestation at birth:

• Birth to age 4 weeks: 3TC 2 mg/kg twice daily

• Age 4–6 weeks: 3TC 4 mg/kg twice daily

Nevirapine (NVP)Nevirapine (NVP)

Not applicable

≥ 37 weeks gestation at birth:

• NVP 6 mg/kg twice daily

34 to < 37 weeks gestation at birth:

• Birth to age 1 week: NVP 4 mg/kg twice daily

• Age 1–6 weeks: NVP 6 mg/kg twice daily

32 to 34 weeks gestation at birth:

• Birth to age 2 weeks: NVP 2 mg/kg twice daily

• Age 2–4 weeks: NVP 4 mg/kg twice daily

• Age 4–6 weeks: NVP 6 mg/kg twice daily 

Raltegravir (RAL)Raltegravir (RAL)

Not applicable

≥ 37 weeks gestation at birth and weighing ≥ 2 kg:

• Birth to age 1 week: About 1.5 mg/kg once a day

• Age 1–4 weeks: About 3 mg/kg twice daily

• Age 4–6 weeks: About 6 mg/kg twice daily