Merck Manual

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Manganese Deficiency

By

Larry E. Johnson

, MD, PhD, University of Arkansas for Medical Sciences

Last full review/revision May 2020| Content last modified May 2020
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Manganese (Mn), necessary for healthy bone structure, is a component of several enzyme systems, including manganese-specific glycosyltransferases and phosphoenolpyruvate carboxykinase. Median intake is between 1.6 and 2.3 mg/day; absorption is 5 to 10%.

Manganese deficiency has not been conclusively documented, although one experimental case in a volunteer resulted in transient dermatitis, hypocholesterolemia, and increased alkaline phosphatase levels.

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