Merck Manual

Please confirm that you are a health care professional

honeypot link

Overview of Interstitial Lung Disease

(Diffuse Parenchymal Lung Diseases)

By

Joyce Lee

, MD, MAS, University of Colorado Denver

Last full review/revision Jun 2021| Content last modified Jun 2021
Click here for Patient Education
Topic Resources

Interstitial lung diseases are a heterogeneous group of disorders characterized by alveolar septal thickening, fibroblast proliferation, collagen deposition, and, if the process remains unchecked, pulmonary fibrosis. Interstitial lung diseases can be classified using various criteria (eg, acute vs chronic, granulomatous vs nongranulomatous, known cause vs unknown cause, primary lung disease vs secondary to systemic disease, history of smoking vs no smoking history).

In up to 30% of patients who have interstitial lung diseases with no clear cause, the disorders are distinguished primarily by characteristic histopathologic features; these disorders are termed the idiopathic interstitial pneumonias Overview of Idiopathic Interstitial Pneumonias Idiopathic interstitial pneumonias (IIPs) are interstitial lung diseases of unknown etiology that share similar clinical and radiologic features and are distinguished primarily by the histopathologic... read more .

Table
icon

Drugs Mentioned In This Article

Drug Name Select Trade
CYTOXAN (LYOPHILIZED)
CONCERTA, RITALIN
FURADANTIN, MACROBID, MACRODANTIN
TEGRETOL
OTREXUP
LEUKERAN
MATULANE
No US brand name
MITOSOL
DOLOPHINE
ALKERAN
MYLERAN
Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Test your knowledge

Wheezing
Wheezing occurs when airflow through a narrowed segment of a small airway becomes turbulent, causing vibration of airway walls. Which of the following is the most common cause of narrowing of the airways? 
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
 

Also of Interest

 
TOP