[{"Title":"References","UniqueID":"v111954462","Index":1.0,"Summary":"

1. Freudenmann RW, Spitzer M. The Neuropsychopharmacology and Toxicology of 3,4-methylenedioxy-N-ethyl-amphetamine (MDEA). CNS Drug Rev. 2004;10(2):89-116. doi:10.1111/j.1527-3458.2004.tb00007.x

","HeadType":"G_Head","SchemeItemProp":"","Children":[]},{"Title":"Pathophysiology","UniqueID":"v111954471","Index":2.0,"Summary":"

MDMA increases the release of serotonin into the synaptic cleft and prevents its reuptake. It also increases the release of noradrenaline and dopamine. Life-threatening hyperthermia and hyponatremia are reported more frequently with MDMA ingestion than with other stimulants. This difference may reflect a combination of unique mechanisms of action and the context in which MDMA is consumed.

","HeadType":"F_Head","SchemeItemProp":"","Children":[]},{"Title":"Symptoms and Signs","UniqueID":"v25243596","Index":3.0,"Summary":"

The effects of use of MDMA (or MDA or MDEA) include a state of excitement and disinhibition and accentuates physical sensation, empathy, and feelings of interpersonal closeness. A useful conceptual model of MDMA effects and toxicity is MDMA = LSD amphetamine. A single dose of MDMA increases heart rate, blood pressure, body temperature and pupil size, like amphetamine, and produces euphoria, difficulty concentrating, and ego dissolution (a sense of being one with the world) like LSD ( 1 ).

","HeadType":"F_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[{"Title":"Symptoms and signs reference","UniqueID":"v111954484","Index":1.0,"Summary":"

","HeadType":"G_Head","SchemeItemProp":"itemprop=\"signOrSymptom\" itemscope itemtype=\"http://schema.org/MedicalSignOrSymptom\"","Children":[]}]},{"Title":"Diagnosis","UniqueID":"v111954490","Index":4.0,"Summary":"

History and physical examination

","HeadType":"F_Head","SchemeItemProp":"","Children":[{"Title":"Diagnosis references","UniqueID":"v111954522","Index":1.0,"Summary":"

History and physical examination

","HeadType":"G_Head","SchemeItemProp":"","Children":[]}]},{"Title":"Treatment","UniqueID":"v25243608","Index":5.0,"Summary":"