Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

Carbohydrates, Proteins, and Fats


Shilpa N Bhupathiraju

, PhD, Harvard Medical School and Brigham and Women's Hospital;

Frank Hu

, MD, MPH, PhD, Harvard T.H. Chan School of Public Health

Reviewed/Revised Feb 2023 | Modified Dec 2023
Topic Resources

Carbohydrates, proteins, and fats are the main types of macronutrients in food (nutrients that are required daily in large quantities). They supply 90% of the dry weight of the diet and 100% of its energy. All three provide energy (measured in calories), but the amount of energy in 1 gram (1/28 ounce) differs:

  • 4 calories in a gram of carbohydrate or protein

  • 9 calories in a gram of fat

These nutrients also differ in how quickly they supply energy. Carbohydrates are the quickest, and fats are the slowest.

Carbohydrates, proteins, and fats are digested in the intestine, where they are broken down into their basic units:

  • Carbohydrates into sugars

  • Proteins into amino acids

  • Fats into fatty acids and glycerol

The body uses these basic units to build substances it needs for growth, maintenance, and activity (including other carbohydrates, proteins, and fats).


Depending on the size of the molecule, carbohydrates may be simple or complex.

Overview of Carbohydrates and Sugars
  • Simple carbohydrates: Various forms of sugar, such as fructose (fruit sugar) and sucrose (table sugar), are simple carbohydrates. They are small molecules, so they can be broken down and absorbed by the body quickly and are the quickest source of energy. They quickly increase the level of blood glucose (blood sugar), which is also a simple carbohydrate. Fruits, dairy products, honey, and maple syrup contain large amounts of simple carbohydrates, which provide the sweet taste in most candies and cakes.

  • Complex carbohydrates: These carbohydrates are composed of long strings of simple carbohydrates. Because complex carbohydrates are larger molecules than simple carbohydrates, they must be broken down into simple carbohydrates before they can be absorbed. Thus, they tend to provide energy to the body more slowly than simple carbohydrates but still more quickly than protein or fat. Because they are digested more slowly than simple carbohydrates, they are less likely to be converted to fat. They also increase blood sugar levels more slowly and to lower levels than simple carbohydrates but for a longer time. Complex carbohydrates include starches and fibers (which occur in wheat products such as breads and pastas), other grains (such as rye and corn), beans, and root vegetables (such as potatoes and sweet potatoes).

Carbohydrates may be

  • Refined

  • Unrefined

Refined means that the food is highly processed. The fiber and bran, as well as many of the vitamins and minerals they contain, have been stripped away. Thus, the body processes these carbohydrates quickly, and they provide little nutrition although they contain about the same number of calories. Refined products are often enriched, meaning vitamins and minerals have been added back to increase their nutritional value. A diet high in simple or refined carbohydrates tends to increase the risk of obesity Obesity Obesity is a chronic, recurring complex disorder characterized by excess body weight. Obesity is influenced by a combination of factors that includes genetics, hormones, behavior, and the environment... read more Obesity and diabetes Diabetes Mellitus (DM) Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. Symptoms of diabetes may... read more .

If people consume more carbohydrates than they need at the time, the body stores some of these carbohydrates within cells (as glycogen) and converts the rest to fat. Glycogen is a complex carbohydrate that the body can easily and rapidly convert to energy. Glycogen is stored in the liver and the muscles. Muscles use glycogen for energy during periods of intense exercise. The amount of carbohydrates stored as glycogen can provide almost a day’s worth of calories. A few other body tissues store carbohydrates as complex carbohydrates that cannot be used to provide energy.

Most authorities recommend that about 50 to 55% of total daily calories should consist of carbohydrates, most coming from fruits, vegetables. beans and legumes, and unrefined grains. Fewer than 10% of total daily calories should come from added sugars. Added sugars are syrups and other caloric sweeteners used in other food products. Added sugars are listed as an ingredient in food labels. They include brown sugar, corn sweetener, corn syrup, dextrose, fructose, glucose, high-fructose corn syrup, honey, invert sugar, lactose, malt syrup, maltose, molasses, raw sugar, sucrose, trehalose, and turbinado sugar. Naturally occurring sugars, such as those in fruit or milk, are not added sugars.

Glycemic index

The glycemic index is a way of classifying food based on how quickly consumption of its carbohydrates increases blood sugar levels. Values range from 1 (the slowest) to 100 (the fastest, the index of pure glucose). However, how quickly the level actually increases also depends on what other foods are ingested at the same time and other factors.

The glycemic index tends to be lower for complex carbohydrates than for simple carbohydrates, but there are exceptions. For example, fructose (the simple carbohydrate sugar in fruits) has a low glycemic index.

The following also influence a food’s glycemic index:

  • Processing: Processed, refined, or finely ground foods tend to have a higher glycemic index.

  • Type of starch: Different types of starch are absorbed differently. For example, potato starch is digested and absorbed into the bloodstream relatively quickly. Starch in barley is digested and absorbed much more slowly.

  • Fiber content: The more fiber a food has, the harder it is to digest. As a result, sugar is absorbed more slowly into the bloodstream.

  • Ripeness of fruit: The riper the fruit, the more sugar it contains, and the higher its glycemic index.

  • Fat or acid content: The more fat or acid a food contains, the more slowly it is digested and the more slowly its sugars are absorbed into the bloodstream.

  • Preparation: How a food is prepared can influence how quickly it is absorbed into the bloodstream. Generally, cooking or grinding a food increases its glycemic index because these processes make food easier to digest and absorb.

  • Other factors: The way the body processes food varies from person to person, affecting how quickly carbohydrates are converted to sugar and absorbed. How well a food is chewed and how quickly it is swallowed also have an effect.


The glycemic index is thought to be important because carbohydrates that increase blood sugar levels quickly (those with a high glycemic index) also quickly increase insulin levels. The increase in insulin may result in low blood sugar levels (hypoglycemia Hypoglycemia Hypoglycemia is abnormally low levels of sugar (glucose) in the blood. Hypoglycemia is most often caused by medications taken to control diabetes. Much less common causes of hypoglycemia include... read more ) and hunger, which tends to lead to consuming excess calories and gaining weight. However, diet experts no longer think that eating foods with a low glycemic index helps people lose weight.

In spite of the association between foods with a low glycemic index and improved health, using the index to choose foods does not automatically lead to a healthy diet. For example, the glycemic index of potato chips and some candy bars—not healthful choices—is lower than that of some healthful foods, such as brown rice. Some foods with a high glycemic index contain valuable vitamins and minerals. Thus, this index should be used only as a general guide to food choices.

Glycemic load

The glycemic index indicates only how quickly carbohydrates in a food are absorbed into the bloodstream. It does not take into account how much carbohydrate a food contains, which is also important. Glycemic load includes the glycemic index and the amount of carbohydrate in a food. A food, such as carrots, bananas, watermelon, or whole-wheat bread, may have a high glycemic index but contain relatively little carbohydrate and thus have a low glycemic load. Such foods have little effect on the blood sugar level.

Glycemic load also includes how changes in blood sugar are affected by the combination of foods eaten together. The glycemic index does not.


Proteins consist of units called amino acids, strung together in complex formations. Because proteins are complex molecules, the body takes longer to break them down. As a result, they are a much slower and longer-lasting source of energy than carbohydrates.

Overview of Proteins

There are 20 amino acids. The body synthesizes some of them from components within the body, but it cannot synthesize 9 of the amino acids—called essential amino acids. They must be consumed in the diet. Everyone needs 8 of these amino acids: isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine. Infants also need a 9th one, histidine.

The percentage of protein the body can use to synthesize essential amino acids varies from protein to protein. The body can use 100% of the protein in egg and a high percentage of the proteins in milk and meats. The body can use a little less than half of the protein in most vegetables and cereals.

The body needs protein to maintain and replace tissues and to function and grow. Protein is not usually used for energy. However, if the body is not getting enough calories from other nutrients or from the fat stored in the body, protein is broken down into ketone bodies to be used for energy. If more protein is consumed than is needed, the body breaks the protein down and stores its components as fat.

The body contains large amounts of protein. Protein, the main building block in the body, is the primary component of most cells. For example, muscle, connective tissues, and skin are all built of protein.

Adults need to eat about 60 grams of protein per day (0.8 grams per kilogram of weight or 10 to 15% of total calories). Whether consuming more helps most adults is controversial. Adults who are trying to build muscle need more. Children also need more protein because they are growing. People who are pregnant or lactating or who have critical illness also need more. People who are limiting calories to lose weight typically need a higher amount of protein to prevent loss of muscle while they are losing weight. Older people may require higher levels of protein up to 1.2 g/kg body weight. However, this amount is excessive and potentially harmful in certain conditions such as renal insufficiency and kidney failure. Studies also show that protein is more satiating (helps people feel full longer) than carbohydrates and fats.


Fats are complex molecules composed of fatty acids and glycerol. The body needs fats for growth and energy. It also uses them to synthesize hormones and many other substances needed for the body’s activities (such as prostaglandins).

Overview of Fats

Fats are the slowest source of energy but the most energy-efficient form of food. Each gram of fat supplies the body with about 9 calories, more than twice that supplied by proteins or carbohydrates. Because fats are such an efficient form of energy, the body stores any excess energy as fat. The body deposits excess fat in the abdomen (visceral fat) and under the skin (subcutaneous fat) to use when it needs more energy. The body may also deposit excess fat in blood vessels and within organs, where it can block blood flow and damage organs, often causing serious disorders.

Fatty acids

When the body needs fatty acids, it can make (synthesize) certain ones. Others, called essential fatty acids, cannot be synthesized and must be consumed in the diet. The essential fatty acids make up about 7% of the fat consumed in a normal diet and about 3% of total calories (about 8 grams). They include linoleic acid and linolenic acid, which are present in certain vegetable oils. Eicosapentaenoic acid and docosahexaenoic acid, which are fatty acids essential for brain development, can be synthesized from linolenic acid. However, they also are present in certain marine fish oils, which are a more efficient source.

Linoleic acid and arachidonic acid are omega-6 fatty acids. Alpha-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid are omega-3 fatty acids. A diet rich in omega-3 fatty acids may reduce the risk of atherosclerosis Atherosclerosis Atherosclerosis is a condition in which patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or... read more Atherosclerosis (including coronary artery disease Overview of Coronary Artery Disease (CAD) Coronary artery disease is a condition in which the blood supply to the heart muscle is partially or completely blocked. The heart muscle needs a constant supply of oxygen-rich blood. The coronary... read more Overview of Coronary Artery Disease (CAD) ). Lake trout and certain deep-sea fish contain large amounts of omega-3 fatty acids. (Women who are pregnant or breastfeeding should choose fish that are low in mercury. See Mercury in Seafood Mercury in seafood Some risk factors are present before women become pregnant. These risk factors include Certain physical characteristics, such as age and weight Problems in a previous pregnancy, including the... read more Mercury in seafood for more information.) In the United States, people tend to consume enough omega-6 fatty acids, which occur in the oils used in many processed foods, but not enough omega-3 fatty acids. The recommended intakes of essential fatty acids can be met with 2 to 3 tablespoons of vegetable fat daily or by consuming a 3.5-ounce portion of fatty fish such as salmon twice a week.


Kinds of fat

There are different kinds of fat:

  • Monounsaturated

  • Polyunsaturated

  • Saturated

Saturated fats are more likely to increase cholesterol levels and increase the risk of atherosclerosis Atherosclerosis Atherosclerosis is a condition in which patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or... read more Atherosclerosis . Foods derived from animals commonly contain saturated fats, which tend to be solid at room temperature. Fats derived from plants commonly contain monounsaturated or polyunsaturated fatty acids, which tend to be liquid at room temperature. Palm and coconut oil are exceptions. They contain more saturated fats than other plant oils.

Trans fats (trans fatty acids) are a different category of fat. They are man-made, formed by adding hydrogen atoms (hydrogenation) to monounsaturated or polyunsaturated fatty acids. Fats may be partially or fully hydrogenated (or saturated with hydrogen atoms). In the United States, the main dietary source of trans fats is partially hydrogenated vegetable oils, previously used in many commercially prepared foods. Consuming trans fats may adversely affect cholesterol levels in the body and may contribute to the risk of atherosclerosis Atherosclerosis Atherosclerosis is a condition in which patchy deposits of fatty material (atheromas or atherosclerotic plaques) develop in the walls of medium-sized and large arteries, leading to reduced or... read more Atherosclerosis . Because of this, the US Food and Drug Administration (FDA) has banned the use of trans fats in prepared foods.

Fat in the diet

Authorities generally recommend that

  • Fat should be limited to less than about 28% of daily total calories (or fewer than 90 grams per day).

  • Saturated fats should be limited to less than 8%.

Eliminating trans fats from the diet is recommended. When possible, monounsaturated fats and polyunsaturated fats, including omega-3 fats, should be substituted for saturated fats and trans fats.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Colief, Lac-Dose , Lactaid, Lactaid Fast Act, Lactrase
Advocate Glucose SOS, BD Glucose, Dex4 Glucose, Glutol , Glutose 15 , Glutose 45 , Glutose 5
Arginine, Nutricia SHS L-Arginine, R-Gene
No brand name available
5-HTP, 5-HTP Maximum Strength
quiz link

Test your knowledge

Take a Quiz!