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Limb Pain


Andrea D. Thompson

, MD, PhD, University of Michigan;

Michael J. Shea

, MD, Michigan Medicine at the University of Michigan

Reviewed/Revised Aug 2022 | Modified Sep 2022
Topic Resources

Limb pain may be constant or occur irregularly. Pain may be precipitated by motion or have no relation to movement. Other symptoms, such as warmth, redness, numbness, or tingling, may also be present, depending on the cause of the limb pain.

Causes of Limb Pain

Injuries and overuse are the most common causes of pain in a limb, but people usually know when these events are the cause of their pain. This discussion covers limb pain unrelated to injury or strain. Among the disorders that cause such limb pain, most affect the legs more than the arms. There are many causes.

The most common causes are the following:

Uncommon but serious causes that require immediate evaluation and treatment include

Evaluation of Limb Pain

It is particularly important to make sure the person does not have a sudden blockage of an artery because the limb can develop gangrene if there is no blood flow for more than a few hours. The following information can help people decide when a doctor's evaluation is needed and help them know what to expect during the evaluation.

Warning signs

In people with limb pain, certain symptoms and characteristics are cause for concern. They include

  • Sudden, severe pain

  • Limb that is cold to the touch or pale

  • Chest pain, sweating, shortness of breath, or palpitations

  • Signs of severe illness (for example, confusion, fever, or collapse)

  • Limb that is suddenly swollen, blistered, or has black spots

  • Risk factors for deep vein thrombosis, such as recent surgery, bed rest, or a cast on a leg

  • New nerve deficits, such as weakness or numbness of the affected limb

When to see a doctor

People who have warning signs should see a doctor right away. People without warning signs should call a doctor. The doctor will decide how quickly the person needs to be seen based on the symptoms, age, and presence of other medical disorders.

What the doctor does

Doctors first ask questions about the person's symptoms and medical history. Doctors then do a physical examination. What they find during the history and physical examination often suggests a cause of the limb pain and the tests that may need to be done.

Doctors ask

  • How long limb pain has been present

  • Whether pain occurs at certain times or during specific activities

  • How intense the pain is

  • Whether the pain is sharp or throbbing

  • Where the pain is located

  • What activities trigger or worsen pain

  • What the person does to relieve pain

  • What other symptoms (such as numbness or tingling) occur along with the pain

Doctors look for symptoms that may indicate a cause of the pain. Some obvious findings may be very helpful in diagnosing the cause of limb pain. For example, back or neck pain suggests that a nerve root may be affected and fever suggests that the person has an infection. Shortness of breath and a rapid heart rate suggest blockage of an artery by a blood clot that has traveled from a leg to the lungs (pulmonary embolism Pulmonary Embolism ). An irregular pulse suggests that the person may have a certain abnormal heart rhythm (atrial fibrillation Atrial Fibrillation and Atrial Flutter Atrial fibrillation and atrial flutter are very fast electrical discharge patterns that make the atria (upper chambers of the heart) contract very rapidly, with some of the electrical impulses... read more ) that has caused a blood clot to travel from the heart to block an artery in the leg.

The painful limb is inspected for color, swelling, and any skin or hair changes. The doctor also checks for pulses, temperature, tenderness, and crepitation (a subtle crackling sensation indicating gas in the soft tissue caused by a serious infection). Strength, sensation, and reflexes are compared between affected and unaffected sides. Blood pressure is sometimes measured in the ankle or wrist of the affected limb and compared with the blood pressure in an unaffected arm or leg. If blood pressure is much lower in the painful limb, it is likely that the arteries in the limb are blocked.



Testing is not needed for all people with limb pain. Doctors can often diagnose some causes of limb pain based on the people's symptoms and the physical examination findings. However, testing is needed in some cases to confirm the diagnosis. For example, doctors may check the ankle-brachial index to diagnose peripheral arterial disease Occlusive Peripheral Arterial Disease Occlusive peripheral arterial disease is blockage or narrowing of an artery in the legs (or rarely the arms), usually due to atherosclerosis and resulting in decreased blood flow. Symptoms depend... read more Occlusive Peripheral Arterial Disease .The blood pressure is measured in both arms and both legs. If blood pressure in the ankle is lower than that in the arms by a certain amount (less than 90% of arm pressure), blood flow to the leg is inadequate.

Treatment of Limb Pain

The best way to treat limb pain is to treat the underlying disorder. Analgesics such as acetaminophen and nonsteroidal anti-inflammatory drugs can help relieve pain. Sometimes opioids are needed.

Key Points

  • In people with sudden, severe pain, blood flow to the limb has often been stopped or reduced and testing must be done quickly.

  • Symptoms and characteristics found during the doctor's examination usually provide clues to the cause of limb pain.

Drugs Mentioned In This Article

Generic Name Select Brand Names
7T Gummy ES, Acephen, Aceta, Actamin, Adult Pain Relief, Anacin Aspirin Free, Aphen, Apra, Children's Acetaminophen, Children's Pain & Fever , Children's Pain Relief, Comtrex Sore Throat Relief, ED-APAP, ElixSure Fever/Pain, Feverall, Genapap, Genebs, Goody's Back & Body Pain, Infantaire, Infants' Acetaminophen, LIQUID PAIN RELIEF, Little Fevers, Little Remedies Infant Fever + Pain Reliever, Mapap, Mapap Arthritis Pain, Mapap Infants, Mapap Junior, M-PAP, Nortemp, Ofirmev, Pain & Fever , Pain and Fever , PAIN RELIEF , PAIN RELIEF Extra Strength, Panadol, PediaCare Children's Fever Reducer/Pain Reliever, PediaCare Children's Smooth Metls Fever Reducer/Pain Reliever, PediaCare Infant's Fever Reducer/Pain Reliever, Pediaphen, PHARBETOL, Plus PHARMA, Q-Pap, Q-Pap Extra Strength, Silapap, Triaminic Fever Reducer and Pain Reliever, Triaminic Infant Fever Reducer and Pain Reliever, Tylenol, Tylenol 8 Hour, Tylenol 8 Hour Arthritis Pain, Tylenol 8 Hour Muscle Aches & Pain, Tylenol Arthritis Pain, Tylenol Children's, Tylenol Children's Pain+Fever, Tylenol CrushableTablet, Tylenol Extra Strength, Tylenol Infants', Tylenol Infants Pain + Fever, Tylenol Junior Strength, Tylenol Pain + Fever, Tylenol Regular Strength, Tylenol Sore Throat, XS No Aspirin, XS Pain Reliever
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