Merck Manual

Please confirm that you are not located inside the Russian Federation

honeypot link

ZAP-70 Deficiency

By

James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Last full review/revision Apr 2021| Content last modified Apr 2021
CLICK HERE FOR THE PROFESSONAL VERSION

ZAP-70 (zeta-associated protein 70) deficiency is a genetic disorder of the immune system that results in an abnormality in T cells that prevents T cells from becoming activated to fight specific infections.

ZAP-70 deficiency causes recurrent infections similar to those in severe combined immunodeficiency Severe Combined Immunodeficiency (SCID) Severe combined immunodeficiency is a primary immunodeficiency disorder resulting in low levels of antibodies (immunoglobulins) and low or no T cells (lymphocytes). Most infants with severe... read more (SCID) in infants and young children. However, the deficiency may not be diagnosed until children are several years old.

More Information about ZAP-70 Deficiency

The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

NOTE: This is the Consumer Version. DOCTORS: CLICK HERE FOR THE PROFESSONAL VERSION
CLICK HERE FOR THE PROFESSONAL VERSION
Others also read
Test your knowledge
Chronic Granulomatous Disease
Chronic granulomatous disease is a hereditary disorder of the immune system. In this disorder, phagocytes, a type of white blood cell, do not function properly. Normal phagocytes ingest and then kill microorganisms invading the body. In chronic granulomatous disease, the phagocytes can ingest invaders but cannot kill them. They lack the ability to produce certain substances that normally enable them to kill. When does chronic granulomatous disease typically first appear?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
TOP