Heredity, side effects of medications, emotionally distressing events, changes in levels of hormones or other substances in the body, and other factors can contribute to depression.
Depression can make people sad and sluggish and/or lose all interest and pleasure in activities they used to enjoy.
Doctors base the diagnosis on symptoms.
Antidepressants, psychotherapy, and sometimes electroconvulsive therapy can help.
(See also Overview of Mood Disorders Overview of Mood Disorders Mood disorders are mental health conditions that involve long periods of excessive sadness (depression), excessive elation (mania), or both. Depression and mania represent the 2 emotional extremes... read more .)
People often use the term depression to describe the sad or discouraged mood that results from emotionally distressing events, such as a natural disaster, a serious illness, or death of a loved one. People may also say they feel depressed at certain times, such as during the holidays (holiday blues) or on the anniversary of a loved one's death. However, such feelings do not usually represent a disorder. Usually, these feelings are temporary, lasting days rather than weeks or months, and occur in waves that tend to be tied to thoughts or reminders of the distressing event. Also, these feelings do not substantially interfere with functioning for any length of time.
Depression is the second most common mental health disorder (anxiety Overview of Anxiety Disorders Anxiety is a feeling of nervousness, worry, or unease that is a normal human experience. It is also present in a wide range of mental health conditions, including generalized anxiety disorder... read more is the most common). About 30% of people who visit a primary care practitioner have symptoms of depression, but fewer than 10% of these people have major depression.
Depression typically develops during a person's mid teens, 20s, or 30s, although depression can begin at almost any age, including during childhood.
An episode of depression, if untreated, typically lasts about 6 months but sometimes lasts for 2 years or more. Episodes tend to recur several times over a lifetime.
Causes of Depression
The exact cause of depression is unclear, but a number of factors may make depression more likely. Risk factors include
A family tendency (heredity)
Emotionally distressing events, particularly those involving a loss
Certain general medical disorders
Side effects of certain medications
Depression does not reflect a weakness of character or a lack of trying to feel better. Social class, race, and culture do not appear to affect the chance that people will experience depression during their lifetime.
Genetic factors contribute to depression in about half the people who have it. For example, depression is more common among first-degree relatives (particularly in an identical twin) of people with depression. Genetic factors can affect the function of substances that help nerve cells communicate (neurotransmitters). Serotonin, dopamine, and norepinephrine are neurotransmitters that may be involved in depression.
Women are more likely than men to experience depression, although the reasons are not entirely clear. Of physical factors, hormones are the ones most involved. Changes in hormone levels can cause mood changes shortly before menstruation (as part of premenstrual syndrome Premenstrual Syndrome (PMS) Premenstrual syndrome (PMS) is a group of physical and psychologic symptoms that start several days before a menstrual period begins and usually end a few hours after the first day of a period... read more ), during pregnancy, after childbirth, and during menopause. Some women become depressed during pregnancy or during the first 4 weeks after giving birth (called baby blues or, if the depression is more serious, postpartum depression Postpartum Depression Postpartum depression is a feeling of extreme sadness and loss of interest in usual activities during the first few weeks or months after delivery. Women who have had depression previously are... read more ). Abnormal thyroid function, which is fairly common among women, may also be a factor.
Depression may occur with or be caused by a number of general medical disorders and factors. These disorders may cause depression directly (as when a thyroid disorder Overview of the Thyroid Gland The thyroid is a small gland, measuring about 2 inches (5 centimeters) across, that lies just under the skin below the Adam’s apple in the neck. The two halves (lobes) of the gland are connected... read more affects hormone levels) or indirectly (as when rheumatoid arthritis Rheumatoid Arthritis (RA) Rheumatoid arthritis is an inflammatory arthritis in which joints, usually including those of the hands and feet, are inflamed, resulting in swelling, pain, and often destruction of joints.... read more causes pain and disability). Often, a disorder both directly and indirectly causes depression. For example, AIDS Acquired immunodeficiency syndrome (AIDS) Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. If untreated, it can cause... read more may cause depression directly if the human immunodeficiency virus (HIV), which causes AIDS, damages the brain. AIDS may cause depression indirectly by having an overall negative effect on the person’s life.
Many people report feeling sadder in late autumn and winter and blame this tendency on the shortening of daylight hours and colder temperatures. However, in some people, such sadness is severe enough to be considered a type of depression (called seasonal affective disorder).
The use of some prescription medications, such as some beta-blockers (used to treat high blood pressure), can cause depression. For unknown reasons, corticosteroids often cause depression when the body produces them in large amounts as part of a disorder (as in Cushing syndrome Cushing Syndrome In Cushing syndrome, the level of corticosteroids is excessive, usually due to taking corticosteroid drugs or overproduction by the adrenal glands. Cushing syndrome usually results from taking... read more ), but when they are given as a medication, they tend to cause hypomania Hypomania In bipolar disorder (formerly called manic-depressive disorder), episodes of depression alternate with episodes of mania (or a less severe form of mania called hypomania). Mania is characterized... read more (a less severe form of mania) or, rarely, mania Mania In bipolar disorder (formerly called manic-depressive disorder), episodes of depression alternate with episodes of mania (or a less severe form of mania called hypomania). Mania is characterized... read more . Sometimes stopping a medication can cause temporary depression.
A number of mental health disorders can predispose a person to depression. They include certain anxiety disorders Overview of Anxiety Disorders Anxiety is a feeling of nervousness, worry, or unease that is a normal human experience. It is also present in a wide range of mental health conditions, including generalized anxiety disorder... read more , alcohol use disorder Alcohol Use Alcohol (ethanol) is a depressant (it slows down brain and nervous system functioning). Consuming large amounts rapidly or regularly can cause health problems, including organ damage, coma,... read more , other substance use disorders Substance Use Disorders Substance use disorders generally involve behavior patterns in which people continue to use a substance (for example, a recreational drug) despite having problems caused by its use. The substances... read more , and schizophrenia Schizophrenia Schizophrenia is a mental disorder characterized by loss of contact with reality (psychosis), hallucinations (usually, hearing voices), firmly held false beliefs (delusions), abnormal thinking... read more . People who have had depression are more likely to have it again.
Emotionally distressing events, such as loss of a loved one, can sometimes trigger depression, but usually only in people who are predisposed to depression, such as those who have family members with depression. However, depression may arise or worsen without any apparent or significant life stresses.
Symptoms of Depression
Symptoms of depression typically develop gradually over days or weeks and can vary greatly. For example, a person who is becoming depressed may appear sluggish and sad or irritable and anxious.
Many people with depression cannot experience emotions—including grief, joy, and pleasure—in a normal way. The world may appear to have become colorless and lifeless. They lose interest or pleasure in activities that they used to enjoy.
People with depression may be preoccupied with intense feelings of guilt and self-denigration and may not be able to concentrate. They may experience feelings of despair, loneliness, and worthlessness. They are often indecisive and withdrawn, feel helpless and hopeless, and think about death and suicide Suicidal Behavior Suicide is death caused by an act of self-harm that is intended to be lethal. Suicidal behavior includes completed suicide, attempted suicide, and suicidal ideation (thoughts and ideas). Suicide... read more .
Most people with depression have difficulty falling asleep and awaken repeatedly, particularly early in the morning. Some people with depression sleep more than usual.
Poor appetite and weight loss may lead to emaciation, and in women, menstrual periods may stop. However, overeating and weight gain are common in people with mild depression.
Some people with depression neglect personal hygiene or even their children, other loved ones, or pets. Some complain of having a physical illness, with various aches and pains.
Major depressive disorder
People with major depressive disorder are depressed most days for at least 2 weeks. They may appear miserable. Their eyes may be full of tears, their brows may be furrowed, and the corners of the mouth may be turned down. They may slump and avoid eye contact. They may hardly move, show little facial expression, and speak in a monotone.
Did You Know...
Persistent depressive disorder
People with persistent depressive disorder have been depressed for most of the time for 2 years or more.
Symptoms begin gradually, often during adolescence, and may last for years or decades. How many symptoms are present at one time varies, and sometimes symptoms are less severe than those in major depression.
People with this disorder may be gloomy, pessimistic, skeptical, humorless, and incapable of having fun. Some are passive, lack energy, and keep to themselves. Some constantly complain and are quick to criticize others and reproach themselves. They may be preoccupied with inadequacy, failure, and negative events, sometimes to the point of morbid enjoyment of their own failures.
Premenstrual dysphoric disorder
Severe symptoms occur before most menstrual periods and disappear after they end. Symptoms cause substantial distress and/or greatly interfere with functioning. Symptoms are similar to those of premenstrual syndrome Premenstrual Syndrome (PMS) Premenstrual syndrome (PMS) is a group of physical and psychologic symptoms that start several days before a menstrual period begins and usually end a few hours after the first day of a period... read more but are more severe, causing great distress and interfering with functioning at work and social interactions.
Premenstrual dysphoric disorder may first appear any time after the first menstrual period. It may worsen as women approach menopause but ends after menopause. It occurs in about 3 to 8% of women who are menstruating.
Women with premenstrual dysphoric disorder have mood swings, suddenly becoming sad and tearful. They are irritable and anger easily. They feel very depressed, hopeless, anxious, and on edge. They may feel overwhelmed or out of control.
As with other types of depression, women with this disorder may lose interest in their usual activities, have difficulty concentrating, and feel tired and without energy. They may eat too much and crave certain foods. They may sleep too little or too much.
Prolonged grief disorder
Prolonged grief is persistent sadness following the loss of a loved one. It is different from depression in that the sadness relates specifically to the loss rather than the more general feelings of sadness and failure associated with depression.
Prolonged grief is considered present when grief (as shown by persistent longing or yearning and/or preoccupation with the deceased) is long-lasting (at least 12 months), experienced a great deal of the time, and is deeper than what a person's culture considers typical. It also must be accompanied by 3 or more of the following for at least 1 month to a degree that causes distress or disability:
Feeling of identity confusion (for example, feeling that part of oneself has died)
Disbelief about the death
Avoidance of reminders of the loss
Intense emotional pain (for example, pain related to the death)
Difficulty engaging in ongoing life
Feelings of numbness
Feelings of meaninglessness
Thoughts of death are among the most serious symptoms of depression. Many people with depression want to die or feel they are so worthless that they should die. As many as 15% of people with untreated depression end their life by suicide Suicidal Behavior Suicide is death caused by an act of self-harm that is intended to be lethal. Suicidal behavior includes completed suicide, attempted suicide, and suicidal ideation (thoughts and ideas). Suicide... read more .
A suicide threat is an emergency. When people threaten to kill themselves, a doctor may hospitalize them so that they can be supervised until treatment reduces the risk of suicide. The risk is especially high in the following situations:
When depression is not treated or is inadequately treated
When treatment is started (when people are becoming more active mentally and physically but their mood is still dark)
When people have a significant anniversary
When people feel very anxious
When people are drinking alcohol or taking illicit drugs
In the weeks to months after people have attempted suicide, particularly if they used a violent method
People with depression are more likely to use alcohol or illicit drugs in an attempt to help them sleep or feel less anxious. However, depression leads to alcohol use disorder Alcohol Use Alcohol (ethanol) is a depressant (it slows down brain and nervous system functioning). Consuming large amounts rapidly or regularly can cause health problems, including organ damage, coma,... read more or other substance use disorders Illicit Drugs and Intoxicants less often than was once thought.
People are also more likely to smoke heavily and to neglect their health. Thus, the risk of developing or worsening other disorders, such as chronic obstructive pulmonary disease Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease is persistent narrowing (blocking, or obstruction) of the airways occurring with emphysema, chronic obstructive bronchitis, or both disorders. Cigarette... read more , is increased.
Other effects of depression
Depression may reduce the immune system's ability to respond to foreign or dangerous invaders, such as microorganisms or cancer cells. As a result, people with depression may be more likely to get infections.
Depression increases the risk of heart and blood vessel disorders (such as heart attacks) and stroke. The reason may be that depression causes certain physical changes that increase this risk. For example, the body produces more of the substances that help blood clot (clotting factors), and the heart is less able to change how fast it beats in response to different situations.
Diagnosis of Depression
A doctor's evaluation, based on standard psychiatric diagnostic criteria
Tests to identify disorders that can cause depression
A doctor is usually able to diagnose depression based on symptoms. Doctors use specific lists of symptoms (criteria) to diagnose the different types of depressive disorders. To help distinguish depression from ordinary changes in mood, doctors determine whether the symptoms are causing significant distress or are impairing the person's ability to function. A previous history of depression or a family history of depression helps support the diagnosis.
Excessive worrying, panic attacks, and obsessions are common in depression and may lead the doctor to incorrectly think that the person has an anxiety disorder Overview of Anxiety Disorders Anxiety is a feeling of nervousness, worry, or unease that is a normal human experience. It is also present in a wide range of mental health conditions, including generalized anxiety disorder... read more .
In older adults, depression may be difficult to notice, especially if they do not work or have little social interaction (see ). Also, depression may be mistaken for dementia Dementia Dementia is a slow, progressive decline in mental function including memory, thinking, judgment, and the ability to learn. Typically, symptoms include memory loss, problems using language and... read more because it can cause similar symptoms, such as confusion and difficulty concentrating and thinking clearly. However, when such symptoms are caused by depression, they resolve when depression is treated. When dementia is the cause, they do not resolve.
A doctor may ask people to fill out a standardized questionnaires to help identify depression and determine how severe it is, but they cannot be used alone to diagnose depression. Two such questionnaires are the Hamilton Depression Rating Scale and the Beck Depression Inventory. For older adults, there is a Geriatric Depression Scale questionnaire. Doctors also ask people whether they have any thoughts or plans to harm themselves. Such thoughts indicate that depression is severe.
No test can confirm depression. However, laboratory tests may help a doctor determine whether depression is caused by a hormonal or other physical disorder. For example, blood tests are usually done to detect a thyroid disorder Overview of the Thyroid Gland The thyroid is a small gland, measuring about 2 inches (5 centimeters) across, that lies just under the skin below the Adam’s apple in the neck. The two halves (lobes) of the gland are connected... read more or vitamin deficiency Overview of Vitamins Vitamins are a vital part of a healthy diet. The recommended dietary allowance (RDA)—the amount most healthy people need each day to remain healthy—has been determined for most vitamins. A safe... read more . Tests may be done to detect illicit drug use.
A thorough neurologic examination Neurologic Examination When a neurologic disorder is suspected, doctors usually evaluate all of the body systems during the physical examination, but they focus on the different parts of the nervous system. Examination... read more is done to check for Parkinson disease Parkinson Disease (PD) Parkinson disease is a slowly progressive degenerative disorder of specific areas of the brain. It is characterized by tremor when muscles are at rest (resting tremor), increased muscle tone... read more , which causes some of the same symptoms.
People who have severely disturbed sleep may need to have sleep testing (polysomnography Testing ) to distinguish sleep disorders Insomnia and Excessive Daytime Sleepiness (EDS) The most commonly reported sleep-related problems are insomnia and excessive daytime sleepiness. Insomnia is difficulty falling asleep or staying asleep, waking up early, or a disturbance in... read more from depression.
Treatment of Depression
Most people with depression do not require hospitalization. However, some people should be hospitalized, especially if they are contemplating suicide or have attempted it, are frail because of weight loss, or are at risk of heart problems because of severe agitation.
Treatment depends on the severity and type of depression:
Mild depression: Support (including frequent doctor visits and education) and psychotherapy
Moderate to severe depression: Medications, psychotherapy, or both and sometimes electroconvulsive therapy
Seasonal depression: Phototherapy
Prolonged grief disorder: Psychotherapy tailored to this disorder
Depression can usually be treated successfully. If a cause (such as a medication or another disorder) can be identified, it is corrected first, but medications to treat depression may also be needed.
Doctors explain to people with depression and their family members that depression has physical causes and requires specific treatment, which is usually effective. Doctors reassure them that depression does not reflect a character flaw, such as weakness. It is important for family members to understand the disorder, be involved in treatment, and provide support.
Learning about depression can help people understand and deal with the disorder. For example, people learn that the path to recovery is often bumpy and that episodes of sadness and dark thoughts may recur but they will stop. Thus, people can put any setbacks in perspective and are more likely to continue their treatment and not give up.
Becoming more active—taking walks and exercising regularly—can help, as can interacting more with others.
Support groups (such as the Depression and Bipolar Support Alliance—DBSA) can help by providing a forum to share common experiences and feelings.
Psychotherapy alone may be just as effective as medications for mild depression. When used with medications, psychotherapy can be useful for severe depression.
Individual or group psychotherapy can help people with depression gradually resume former responsibilities and adapt to the normal pressures of life. Interpersonal therapy focuses on the person's past and present social roles, identifies problems with how the person interacts with other people, and provides guidance as the person adjusts to changes in life roles. Cognitive-behavioral therapy can help change hopelessness and negative thinking.
Medications for depression
Several types of antidepressants Medications for Treatment of Depression Several types of medications can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Norepinephrine-dopamine reuptake inhibitors, serotonin modulators, and serotonin-norepinephrine... read more are available (see table ). They include the following:
Selective serotonin reuptake inhibitors Selective serotonin reuptake inhibitors (SSRIs) Several types of medications can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Norepinephrine-dopamine reuptake inhibitors, serotonin modulators, and serotonin-norepinephrine... read more (SSRIs)
Newer antidepressants Norepinephrine-dopamine reuptake inhibitors, serotonin modulators, and serotonin-norepinephrine reuptake inhibitors Several types of medications can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Norepinephrine-dopamine reuptake inhibitors, serotonin modulators, and serotonin-norepinephrine... read more
Ketamine and esketamine
Psychostimulants Drug therapy Attention-deficit/hyperactivity disorder (ADHD) is poor or short attention span and/or excessive activity and impulsiveness inappropriate for the child’s age that interferes with functioning... read more , such as dextroamphetamine and methylphenidate, as well as other medications, are sometimes used, often with antidepressants. Psychostimulants are used to increase mental alertness and awareness.
St. John’s wort St. John’s Wort The reddish substance in the flowers of St. John’s wort contains numerous biologically active compounds, including hypericin and hyperforin. (See also Overview of Dietary Supplements.) People... read more , an herbal dietary supplement, is sometimes used to relieve mild depression, although its effectiveness is not proven. Due to potentially harmful interactions between St. John’s wort and many prescription medications, people interested in taking this herbal supplement need to discuss possible drug interactions with their doctor.
Electroconvulsive therapy (in the past sometimes called shock therapy) is sometimes used to treat people with severe depression, including people who have psychosis, are threatening suicide, or are refusing to eat. It is also used to treat depression during pregnancy when medications are ineffective.
This type of therapy is usually very effective and can relieve depression quickly, unlike most antidepressants, which can take up to several weeks. The speed with which it takes effect can save lives. After electroconvulsive therapy is stopped, episodes of depression can recur. To help prevent them, doctors often prescribe antidepressants.
For electroconvulsive therapy, electrodes are placed on the head, and an electrical current is applied to induce a seizure in the brain. For reasons that are not understood, the seizures relieve depression. Usually, at least 5 to 7 treatments (one treatment every other day) are given.
Because the electrical current can cause muscle contractions and pain, general anesthesia is required during treatments. Electroconvulsive therapy may cause some temporary memory loss and, rarely, permanent memory loss.
Phototherapy using a light therapy box is the most effective treatment for seasonal depression but may be helpful for other types of depressive disorders.
Phototherapy involves sitting a specific distance from a light box that provides light with the necessary intensity. People are instructed not to look directly at the light and to remain in front of the light for 30 to 60 minutes a day. Phototherapy can be done at home.
If people go to sleep and get up late, phototherapy is most effective in the morning. If people go to sleep and get up early, phototherapy is most effective between the late afternoon and early evening.
Other therapies that stimulate the brain may be tried when initial treatments are ineffective. They include
Repetitive transcranial magnetic stimulation
Stimulation of the vagus nerve
The stimulated cells are thought to release chemical messengers (neurotransmitters), which help regulate mood and may thus relieve symptoms of depression. These therapies may help people with severe depression that does not respond to medications or psychotherapy.
For repetitive transcranial magnetic stimulation, an electromagnetic coil is placed against the forehead near an area of the brain thought to be involved in regulating mood. The electromagnet produces painless magnetic pulses that doctors think stimulate nerve cells in the targeted area of the brain. The most common side effects are headaches and discomfort near where the coil was placed.
For vagus nerve stimulation, a device that looks like a heart pacemaker (vagus nerve stimulator) is implanted under the left collarbone and is connected to the vagus nerve in the neck with a wire that runs under the skin. (The pair of vagus nerves run from the brain stem, located near the base of the skull, through the neck and down each side of the chest and abdomen to organs, such as the heart and lungs.) The device is programmed to periodically stimulate the vagus nerve with a painless electrical signal. It may be useful for depression when other treatments are ineffective, but it usually takes 3 to 6 months to take effect. Side effects of vagus nerve stimulation include hoarseness, cough, and deepening of the voice when the nerve is stimulated.
The following English-language resources may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
Depression and Bipolar Support Alliance (DBSA), Depression: General information on depression, including access to crisis lines and support groups
Mental Health America (MHA), Depression: General information on depression, including its various types, access to crisis lines and support groups, and links to other resources
National Alliance on Mental Illness (NAMI), Depression: General information on depression, including its causes, symptoms, diagnosis, and treatment
National Institutes of Mental Health (NIMH), Depression: General information on many aspects of depression, including treatment and therapies, educational materials, and information on research and clinical trials
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