Dry mouth is caused by a reduced or absent flow of saliva. This condition can cause discomfort, interfere with speech and swallowing, make wearing dentures difficult, cause bad breath Bad Breath Bad breath is a frequent or persistent unpleasant odor to the breath. Certain diseases produce substances that are detectable on the breath, but these odors are typically mild and not considered... read more (halitosis), and worsen oral hygiene by causing a decrease in the acidity of the mouth and an increase in bacterial growth, which contributes to the development of cavities Cavities Cavities are decayed areas in the teeth, the result of a process that gradually dissolves a tooth’s hard outer surface (enamel) and progresses toward the interior. (See also Overview of Tooth... read more . Longstanding dry mouth can result in severe tooth decay and candidiasis Candidiasis Candidiasis is a fungal infection caused by several species of the yeast Candida, especially Candida albicans. The most common type of candidiasis is a superficial infection of... read more of the mouth. Dry mouth is a common complaint among older people.
Causes of Dry Mouth
Dry mouth occurs when the salivary glands (glands in the mouth that produce saliva) malfunction and thus decrease saliva production. There are many causes, including dehydration and mouth breathing (see table Some Causes of Dry Mouth Some Causes of Dry Mouth ).
The most common causes of dry mouth are
Radiation to the head and neck (for cancer treatment)
Drugs are the most common cause overall. About 400 prescription drugs and many nonprescription (over-the-counter) drugs cause a decrease in saliva production. The most common classes of drugs include the following:
Drugs that have anticholinergic effects (drugs that block acetylcholine)
Antiparkinsonian drugs (drugs used to treat Parkinson disease)
Cancer chemotherapy drugs
Many chemotherapy drugs cause severe dryness and mouth sores Mouth Sores and Inflammation Mouth sores and inflammation vary in appearance and size and can affect any part of the mouth, including the lips (see Lip Sores and Inflammation). People may have swelling and redness of the... read more (stomatitis) while they are being taken. These problems usually end after the drugs are stopped.
Other common drugs that cause dry mouth include certain antihypertensives Medications for Treatment of High Blood Pressure High blood pressure is very common. It often does not cause symptoms; however, high blood pressure can increase the risk of stroke, heart attack, and heart failure. Therefore, it is important... read more (drugs used to lower high blood pressure), antianxiety drugs Misuse of Antianxiety Medications and Sedatives Antianxiety and sedative medications are prescription drugs used to relieve anxiety and/or help with sleep, but their use can result in dependency and a substance use disorder. Using prescription... read more (drugs used to treat anxiety disorders), and antidepressants Medications for Treatment of Depression Several types of medications can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Norepinephrine-dopamine reuptake inhibitors, serotonin modulators, and serotonin-norepinephrine... read more (drugs used to treat depression).
Illegal methamphetamine use has resulted in a disorder called meth mouth, which is severe tooth decay caused by methamphetamine-induced dry mouth. The damage is worsened by the tooth grinding and clenching caused by the drug, the heat of the inhaled vapor, and probably elevated intake of sugary beverages and poor oral hygiene while using this drug. This combination causes very rapid destruction of teeth and a lifetime of dental problems for younger people.
Tobacco use usually causes a decrease of saliva.
Radiation therapy for head and neck cancer can severely damage the salivary glands, often causing permanent dryness. Even low doses of radiation can cause temporary drying.
Less common causes of dry mouth include bodywide (systemic) disorders. Dry mouth is very common among people with Sjögren syndrome Sjögren Syndrome Sjögren syndrome is a common autoimmune connective tissue disorder and is characterized by excessive dryness of the eyes, mouth, and other mucous membranes. White blood cells can infiltrate... read more . Some people with diabetes Diabetes Mellitus (DM) Diabetes mellitus is a disorder in which the body does not produce enough or respond normally to insulin, causing blood sugar (glucose) levels to be abnormally high. Symptoms of diabetes may... read more or HIV infection Human Immunodeficiency Virus (HIV) Infection have problems with dry mouth.
Evaluation of Dry Mouth
Not all people with a dry mouth need to be immediately evaluated by a doctor. The following information can help people decide whether a doctor’s evaluation is needed and help them know what to expect during the evaluation.
In people with dry mouth, certain symptoms and characteristics are cause for concern. They include
Extensive tooth decay
Dry eyes, dry skin, rash, or joint pain
When to see a doctor
People who have warning signs should see a doctor right away. People with extensive tooth decay should have a dental examination. People with a dry mouth but no warning signs and who otherwise feel well may see their doctor within a week or so.
What the doctor does
Doctors first ask questions about the person’s symptoms and medical history. Symptoms of dry or irritated eyes, dry skin, rash, and/or joint pain raise the possibility of Sjögren syndrome Sjögren Syndrome Sjögren syndrome is a common autoimmune connective tissue disorder and is characterized by excessive dryness of the eyes, mouth, and other mucous membranes. White blood cells can infiltrate... read more . Doctors also ask about a history of past or current radiation treatment, head and neck trauma, and a diagnosis of or risk factors for HIV infection. Doctors need to know all the drugs a person is taking to find out whether any are causing the dry mouth.
Doctors then do a physical examination. The physical examination is focused on the mouth, to see the degree of dryness. If the degree of dryness is unclear, doctors can hold a tongue depressor against the inside of the cheek for 10 seconds. If the tongue depressor falls off immediately when released, the flow of saliva is considered normal. If there is difficulty removing the tongue depressor, the flow of saliva is not normal. In women, the lipstick sign, where lipstick sticks to the front teeth, may be a useful indicator of dry mouth.
Doctors also examine the mouth for the presence of any sores caused by the fungus Candida albicans and check the condition of the teeth (for instance, whether there are any cavities in unusual places). Unexpectedly severe and rapid tooth decay may be a sign of illicit drug use, particularly methamphetamines Amphetamines Amphetamines are stimulant drugs that are used to treat certain medical conditions but are also subject to abuse. Amphetamines increase alertness, enhance physical performance, and produce euphoria... read more .
What doctors find during the history and physical examination often suggests a cause of the dry mouth (see table Some Causes of Dry Mouth Some Causes of Dry Mouth ) and the tests that may need to be done. If the dry mouth began shortly after a new drug was started, doctors often try stopping the drug to see whether symptoms go away.
Sometimes, doctors test how well the salivary glands are functioning by measuring the flow of saliva (a test called sialometry). People chew paraffin or apply citric acid to the tongue to stimulate the flow of saliva, and then doctors collect the saliva. Measuring the flow of saliva can help doctors determine whether the dry mouth is getting better or worse.
If doctors are unable to determine the cause of dry mouth, people should usually undergo a biopsy (removal of a sample of tissue for examination under a microscope) of a minor salivary gland on the lower lip to detect Sjögren syndrome Sjögren Syndrome Sjögren syndrome is a common autoimmune connective tissue disorder and is characterized by excessive dryness of the eyes, mouth, and other mucous membranes. White blood cells can infiltrate... read more , sarcoidosis Sarcoidosis Sarcoidosis is a disease in which abnormal collections of inflammatory cells (granulomas) form in many organs of the body. Sarcoidosis usually develops in people aged 20 to 40 years, most often... read more , amyloidosis Amyloidosis Amyloidosis is a rare disease in which abnormally folded proteins form into collections called amyloid fibrils that accumulate in various tissues and organs, sometimes leading to organ dysfunction... read more , tuberculosis, Tuberculosis (TB) Tuberculosis is a chronic contagious infection caused by the airborne bacteria Mycobacterium tuberculosis. It usually affects the lungs, but almost any organ can be involved. Tuberculosis... read more or cancer. They may also consider HIV testing Diagnosis Human immunodeficiency virus (HIV) infection is a viral infection that progressively destroys certain white blood cells and is treated with antiretroviral medications. If untreated, it can cause... read more .
Treatment of Dry Mouth
Treatment of the cause, including stopping causative drugs when possible
Sometimes drugs to increase saliva production
Regular oral hygiene and dental care
When possible, the cause of dry mouth is treated. For people with drug-related dry mouth whose current drug cannot be stopped or changed to another drug, drugs should be taken in the morning rather than at night, because nighttime dry mouth is more likely to cause cavities Cavities Cavities are decayed areas in the teeth, the result of a process that gradually dissolves a tooth’s hard outer surface (enamel) and progresses toward the interior. (See also Overview of Tooth... read more . For all drugs, easy-to-take formulations, such as liquids, should be considered. Drugs that need to be placed under the tongue should be avoided. People should drink water before swallowing capsules and tablets or before placing nitroglycerin under the tongue. People also should avoid decongestants and antihistamines.
Treatment that helps control the symptoms of dry mouth consists of measures that
Increase existing saliva
Replace saliva with other liquid
Drugs that increase saliva production include cevimeline and pilocarpine. The main side effect of cevimeline is nausea. The main side effects of pilocarpine include sweating, flushing, and excreting large volumes of diluted urine (polyuria).
Sipping sugarless fluids frequently and chewing gum that contains xylitol helps stimulate saliva flow. Using an over-the-counter saliva substitute containing carboxymethylcellulose, hydroxyethylcellulose, or glycerin may also help.
Petroleum jelly can be applied to the lips and under dentures to relieve drying, cracking, soreness, and trauma of the lining of the mouth. A cold-air humidifier may aid mouth breathers, who typically have their worst symptoms at night.
Meticulous oral hygiene is essential. People should brush (using a commercial or prescription fluoride toothpaste) and floss regularly (including just before bedtime) and use fluoride rinses or gels daily. Newer toothpastes with added calcium and phosphates also may help prevent cavities. People should see their dentist more often for preventive dental care and plaque removal. The most effective way to prevent cavities is to use custom-fitted mouth trays filled with prescription toothpaste for at-home fluoride application, especially at night. People may prefer to apply prescription fluoride toothpaste to the teeth without using a tray. In addition, a dentist can apply a sodium fluoride varnish 2 to 4 times per year.
People should avoid sugary or acidic foods and beverages and any irritating foods that are dry, spicy, or excessively hot or cold. People should especially avoid sugar near bedtime.
Essentials for Older People
Dry mouth is more common among older people, but this is probably due to the many drugs typically used by older people rather than aging itself.
Drugs are the most common cause, but some diseases (most commonly Sjögren syndrome or HIV infection) and radiation therapy can also cause dry mouth.
Saliva flow can be increased by chewing gum that contains xylitol or sucking on sugarless candy, by taking certain drugs, and by using artificial saliva replacement.
Because people with dry mouth are at high risk of tooth decay, meticulous oral hygiene, additional preventive measures at home (including daily use of over-the-counter fluoride rinses or dentist-prescribed fluoride toothpaste), and dentist-applied fluoride are essential.
The following is an English-language resource that may be useful. Please note that THE MANUAL is not responsible for the content of this resource.
MouthHealthy.org: Provides information on oral health, including nutrition and guidance on selecting products that carry the American Dental Association's seal of approval. There is also advice on finding a dentist and how and when to see one.
Drugs Mentioned In This Article
|Generic Name||Select Brand Names|
|Deponit, GONITRO , Minitran, Nitrek, Nitro Bid, Nitrodisc, Nitro-Dur, Nitrogard , Nitrol, Nitrolingual, NitroMist , Nitronal, Nitroquick, Nitrostat, Nitrotab, Nitro-Time, RECTIV, Transdermal-NTG, Tridil|
|Adsorbocarpine, Akarpine, Isopto Carpine, Ocu-Carpine, Pilocar, Pilopine HS, Salagen, Vuity|
|Colace Glycerin, Fleet, Fleet Pedia-Lax, HydroGel, Introl , Lubrin, Orajel Dry Mouth, Osmoglyn, Sani-Supp|
|ACT Anti Cavity Flouride, ACT Dry Mouth Anti Cavity with Xylitol, biotene Dry Mouth, biotene PBF Dry Mouth, Blank, Denta 5000 Plus, Dentagel, Dental Resources Neutral, Duraflor, Epiflur, EtheDent, Fluorabon, Fluor-A-Day, Fluorident , FLUORIDEX, Fluorinse, Fluorishield (Sodium Fluoride), Fluoritab, FluoroCare Neutral, Flura-Drops, Flura-Loz, Karigel, Karigel-N, Listerine Smart Rinse, Lozi Flur, Ludent, Luride, Morning Fresh, NaFrinse, Neutracare, Neutragard, Neutral, Neutral Floam, Neutral One Minute, Nice, Pediaflor, Perfect Choice Neutral, Pharmaflur , Phos-Flur, Plus Neutral, PreviDent, PreviDent 5000 Booster , PreviDent 5000 Booster Plus, PreviDent 5000 Dry Mouth, PreviDent 5000 ORTHO DEFENSE, PreviDent 5000 Plus, PreviDent Dental, Protect , ReNaf, SF 5000 Plus, SodiPhluor, Sultan/Topex Neutral Ph, Thera-Flur, Thera-Flur N, Wenthworth, Wentworth, Wentworth Sodium Fluoride, White Coral|