Table: Conditions That Occur With Certain Multiple Endocrine Neoplasia Syndromes

Conditions That Occur With Certain Multiple Endocrine Neoplasia Syndromes

Condition	MEN 1	MEN 2A	MEN 2B
Hyperparathyroidism Hyperparathyroidism In hypercalcemia, the level of calcium in blood is too high. A high calcium level may result from a problem with the parathyroid glands, as well as from diet, cancer, or disorders affecting... read more (high levels of parathyroid hormone)	95% or more	10–20%	—
Pancreas tumors Overview of Pancreatic Endocrine Tumors The pancreas is an organ located in the upper part of the abdomen. It produces digestive juices that are secreted into the digestive tract. The pancreas also produces insulin, which helps control... read more	30–80%	—	—
Pituitary gland tumors	15–42%	—	—
Thyroid gland tumors (specifically medullary carcinoma Medullary thyroid cancer The cause of thyroid cancer is not known, but the thyroid gland is very sensitive to radiation, which may cause cancerous changes. Thyroid cancer is more common among people who were treated... read more )	—	More than 95%	More than 95%
Pheochromocytoma Pheochromocytoma A pheochromocytoma is a tumor that usually originates from the adrenal glands’ chromaffin cells, causing overproduction of catecholamines, powerful hormones that induce high blood pressure and... read more (tumor of the adrenal glands)	—	40–50%	50%
Neuromas (growths around nerves) on mucous membranes	—	—	Almost 100%
Physical characteristics similar to those in people with Marfan syndrome Marfan Syndrome Marfan syndrome is a rare hereditary disorder of connective tissue, resulting in abnormalities of the eyes, bones, heart, blood vessels, lungs, and central nervous system. This syndrome is caused... read more	—	—	Almost 100%
MEN = multiple endocrine neoplasia.