Ablation for Cardiac Arrhythmia

The need for treatment of arrhythmias Overview of Arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial... read more depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic drugs Medications for Arrhythmias The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more , cardioversion-defibrillation Direct Current (DC) Cardioversion-Defibrillation The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more , implantable cardioverter-defibrillators Implantable Cardioverter-Defibrillators (ICD) The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more (ICDs), pacemakers Cardiac Pacemakers The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more (and a special form of pacing, cardiac resynchronization therapy Cardiac Resynchronization Therapy (CRT) The need for treatment of arrhythmias depends on the symptoms and the seriousness of the arrhythmia. Treatment is directed at causes. If necessary, direct antiarrhythmic therapy, including antiarrhythmic... read more ), catheter ablation, surgery Surgery for cardiac arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial... read more , or a combination, is used.

If a tachyarrhythmia depends on a specific pathway or ectopic site of automaticity, the site can be purposefully destroyed (ablated) to effect cure. Methods of ablation include

Radiofrequency ablation is usually accomplished using transvenous catheter supplied low-voltage, high-frequency (300 to 750 MHz) electrical radiofrequency (RF) energy. This energy heats and necroses an area < 1 cm in diameter and up to 1 cm deep.

Cryoablation uses tissue freezing (to -70° C) to effect tissue destruction. Other delivery systems have been developed for intraoperative use.

Laser energy can be delivered using a transvenous catheter and ablate a target area.

Pulsed electrical field ablation uses a train of high voltage, short duration electrical impulses that kill cardiac myocytes in a non-thermal method. The electrical current causes pores to develop in the cell membrane, destroying the cell. Myocytes are more sensitive to this stimulus than many other cells so collateral structures may experience less damage. This ablation technique is sufficiently painful that general anesthesia is required.

Before energy can be applied, the target site or sites must be identified during an electrophysiologic study Electrophysiologic Studies (EPS) In electrophysiologic studies (EPS), recording and stimulating electrodes are inserted into all 4 cardiac chambers via right- or left-sided cardiac catheterization. Atria are paced from the... read more .

Success rate is > 90% for reentrant supraventricular tachycardias Reentrant Supraventricular Tachycardias (SVT) Including Wolff-Parkinson-White Syndrome Reentrant supraventricular tachycardias (SVT) involve reentrant pathways with a component above the bifurcation of the His bundle. Patients have sudden episodes of palpitations that begin and... read more (via the atrioventricular [AV] node or an accessory pathway), focal atrial tachycardia and atrial flutter Atrial Flutter Atrial flutter is a rapid regular atrial rhythm due to an atrial macroreentrant circuit. Symptoms include palpitations and sometimes weakness, effort intolerance, dyspnea, and presyncope. Atrial... read more , and focal idiopathic ventricular tachycardia (VT—right ventricular outflow tract, left septal, or bundle branch reentrant VT).

Because atrial fibrillation (AF) Atrial Fibrillation Atrial fibrillation is a rapid, irregularly irregular atrial rhythm. Symptoms include palpitations and sometimes weakness, effort intolerance, dyspnea, and presyncope. Atrial thrombi may form... read more often originates in or is maintained by an arrhythmogenic site in the pulmonary veins, this source can be electrically isolated by ablations at the pulmonary vein–left atrial junction or in the left atrium. Alternatively, in patients with refractory AF and rapid ventricular rates, the AV node may be ablated after permanent pacemaker implantation. Ablation is sometimes successful in patients with VT refractory to drugs, particularly when ischemic heart disease is present.

Transcatheter ablation is safe. Mortality risk is higher in complex procedures. Mortality is < 1/2000 for noncomplex ablation procedures but may be as high as 1/500 for pulmonary vein isolation procedures for atrial fibrillation or ventricular tachycardia substrate ablation procedures.

Complications include valvular damage, pulmonary vein stenosis or occlusion (if used to treat atrial fibrillation), stroke or other embolism, cardiac perforation, tamponade (1%), and unintended AV node ablation.