Merck Manual

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Superficial Venous Thrombosis


James D. Douketis

, MD, McMaster University

Reviewed/Revised Sep 2022
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Superficial venous thrombosis is a blood clot in a superficial vein of the upper or lower extremities or, less commonly, in one or more veins of the chest or breast (Mondor disease).

Superficial venous thrombosis in the upper extremity most commonly results from IV infusions or catheterization; varicose veins seem to be the main risk factor for the lower extremity, especially among women. Superficial venous thrombi rarely cause serious complications and rarely become emboli.

Typically, patients present with pain, tenderness, or an indurated cord along a palpable superficial vein. The overlying skin is usually warm and erythematous.

Migratory superficial venous thrombosis, which develops, resolves, and recurs in normal veins of the arms, legs, and torso at various times, is a possible harbinger of pancreatic cancer Pancreatic Cancer Pancreatic cancer, primarily ductal adenocarcinoma, accounts for an estimated 57,600 cases and 47,050 deaths in the US annually ( 1). Symptoms include weight loss, abdominal pain, and jaundice... read more and other adenocarcinomas (Trousseau syndrome).

Diagnosis is based on history and physical examination. Patients with superficial venous thrombosis above the knee have an increased risk of deep venous thrombosis Deep Venous Thrombosis (DVT) Deep venous thrombosis (DVT) is clotting of blood in a deep vein of an extremity (usually calf or thigh) or the pelvis. DVT is the primary cause of pulmonary embolism. DVT results from conditions... read more Deep Venous Thrombosis (DVT) (DVT) and should probably have ultrasonography.

Treatment of Superficial Venous Thrombosis

  • Warm compresses and nonsteroidal anti-inflammatory drugs (NSAIDs)

  • Sometimes anticoagulation

Treatment of superficial venous thrombosis traditionally involves warm compresses and NSAIDs.

In patients with extensive superficial venous thrombosis, anticoagulation (eg, with low molecular weight heparin, fondaparinux) is often beneficial. The optimal regimen and duration are unknown, but most experts recommend treating for about 1 month using either low molecular weight heparin (eg, enoxaparin 40 mg subcutaneously once a day) or fondaparinux (2.5 mg subcutaneously once a day).

Drugs Mentioned In This Article

Drug Name Select Trade
Hepflush-10 , Hep-Lock, Hep-Lock U/P, Monoject Prefill Advanced Heparin Lock Flush, SASH Normal Saline and Heparin
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NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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