Hidradenitis suppurativa is a chronic, scarring, acnelike inflammatory process that occurs in the axillae, groin, and around the nipples and anus. Diagnosis is by examination. Treatment depends on stage.
Hidradenitis suppurativa is currently thought to be a chronic inflammatory condition of the hair follicle and associated structures. Follicular inflammation and subsequent occlusion leads to rupture of the follicle and development of abscesses, sinus tracts, and scarring.
Swollen, tender masses resembling cutaneous abscesses develop. These lesions are often sterile. Pain, fluctuance, discharge, and sinus tract formation are characteristic in chronic cases. In chronic cases, bacterial infection may occur in deep abscesses and sinus tracts. In chronic axillary cases, coalescence of inflamed nodules causes palpable cordlike fibrotic bands. The condition may become disabling because of pain and foul odor.
Diagnosis of Hidradenitis Suppurativa
Clinical evaluation
Photo courtesy of Karen McKoy, MD.
© Springer Science+Business Media
© Springer Science+Business Media
Photo courtesy of Karen McKoy, MD.
© Springer Science+Business Media
© Springer Science+Business Media
Diagnosis of hidradenitis suppurativa is by examination. Cultures should be taken from deep abscesses and sinus tracts in patients who have chronic disease, but often no pathogens will be found. The Hurley staging system describes the severity of disease:
Stage I: Abscess formation, single or multiple, without sinus tracts or scarring
Stage II: Single or multiple, widely separated, recurrent abscesses with sinus tract formation or scarring
Stage III: Diffuse or near diffuse involvement or multiple interconnected sinus tracts and abscesses across the entire area
Treatment of Hidradenitis Suppurativa
Stage II: Longer courses of oral antibiotics, antiandrogenic agents, and sometimes drainage, de-roofing, or punch debridement
Hidradenitis suppurative treatment goals are to prevent new lesions, reduce inflammation, and remove sinus tracts (1).
For Hurley stage I disease,
For Hurley stage II disease,
For Hurley Stage III disease,2345). Wide surgical excision and repair or grafting of the affected areas is often necessary if the disease persists. Ablative laser therapy (CO2 or erbium:YAG) is an alternate surgical treatment (6). Laser hair removal has also been used with some success (7).
Recommended adjunctive measures for all patients with hidradenitis suppurativa include maintaining good skin hygiene, minimizing trauma, providing psychological support, and possibly avoiding high glycemic–load foods.
Treatment references
1. Alikhan A, Sayed C, Alavi A, et al: North American clinical management guidelines for hidradenitis suppurativa: A publication from the United States and Canadian Hidradenitis Suppurativa Foundations: Part II: Topical, intralesional, and systemic medical management. J Am Acad Dermatol 81(1):91-101, 2019. doi: 10.1016/j.jaad.2019.02.068
2. Shih T, Lee K, Grogan T, Deet alDermatol Ther 35(9):e15691, 2022. doi: 10.1111/dth.15691
3. Kimball AB, Okun MM, Williams DA, et alN Engl J Med 375(5):422-434, 2016. doi: 10.1056/NEJMoa1504370
4. Kimball AB, Jemec GBE, Alavi A, et alLancet 401(10378):747-761, 2023. doi: 10.1016/S0140-6736(23)00022-3
5. Matusiak L, Bieniek A, Szepietowski JCBr J Dermatol 171(1):170-174, 2014. doi: 10.1111/bjd.12884
6. Tierney E, Mahmoud BH, Hexsel C, et al: Randomized control trial for the treatment of hidradenitis suppurativa with a neodymium-doped yttrium aluminium garnet laser. Dermatologic Surgery 35(8):1188-1198, 2009. doi: 10.1111/j.1524-4725.2009.01214.x
7. Xu LY, Wright DR, Mahmoud BH, et al: Histopathologic study of hidradenitis suppurativa following long-pulsed 1064-nm Nd:YAG laser treatment. Arch Dermatol 147(1):21-28, 2011. doi: 10.1001/archdermatol.2010.245
Key Points
Lesions are usually sterile except for deep abscesses and sinus tracts in chronic disease.
Hidradenitis suppurativa can be disabling.
Treat hidradenitis suppurativa based on the Hurley staging system.
Adjunctive measures include maintaining good skin hygiene, minimizing trauma, providing psychological support, and possibly avoiding a high glycemic load diet.
