Merck Manual

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Shinjita Das

, MD, Harvard Medical School

Last review/revision Apr 2022 | Modified Sep 2022
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Hypohidrosis is inadequate sweating.

Hypohidrosis is a feature of some genetic conditions (eg, hypohidrotic and anhidrotic ectodermal dysplasia). A mutation of a single gene (ITPR2), which encodes a calcium channel, results in anhidrosis, the complete absence of sweating (1 Reference Hypohidrosis is inadequate sweating. Hypohidrosis due to skin abnormalities is rarely clinically significant. It is most commonly focal and caused by local skin injury (eg, due to trauma, radiation... read more ).

Hypohidrosis may be caused by drugs, especially those with anticholinergic properties. It is also caused by diabetic neuropathy and a variety of congenital syndromes. Heatstroke Heatstroke Heatstroke is hyperthermia accompanied by a systemic inflammatory response causing multiple organ dysfunction that may result in death. Symptoms include temperature > 40° C and altered mental... read more causes inadequate sweating but is a central nervous system disorder rather than a skin disorder.

Diagnosis of hypohidrosis is by clinical observation of decreased sweating or by heat intolerance.

Treatment of hypohidrosis is by cooling measures (eg, air-conditioning, wet garments).


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