Merck Manual

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Hematopoietic Cell Transplantation

By

Robert Peter Gale

, MD, PhD, DSC(hc), Imperial College London

Last full review/revision Sep 2020| Content last modified Sep 2020
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Hematopoietic cell transplants Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders... read more using cells from bone marrow, blood, or less often, umbilical cord blood cells are given after high- or moderate-dose chemotherapy and/or radiation therapy. Donors can be the person with cancer (an autotransplant) or an HLA-matched related or unrelated person (an allotransplant—see also Overview of Cancer Therapy Overview of Cancer Therapy Curing cancer requires eliminating all cells capable of causing cancer recurrence in a person's lifetime. The major modalities of therapy are Surgery (for local and local-regional disease) Radiation... read more ). Typically, such transplants are reserved for patients with a high risk that conventional therapies will fail or in whom initial therapy has failed.

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