Immunology; Allergic Disorders
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Biology of the Immune SystemThe immune system distinguishes self from nonself and eliminates potentially harmful nonself molecules and cells from the body. The immune system also has the capacity to recognize and destroy abnormal cells that derive from host tissues. Any molecule capable of being recognized by the immune system is considered an antigen (Ag).
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Allergic, Autoimmune, and Other Hypersensitivity DisordersAllergic (including atopic) and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. Inappropriate immune reactions include those that are misdirected against intrinsic body components (self), leading to autoimmune disorders. This topic focuses on type I hypersensitivity reactions.
- Overview of Allergic and Atopic Disorders
- Allergic Rhinitis
- Anaphylaxis
- Angioedema
- Hereditary and Acquired Angioedema
- Autoimmune Disorders
- Drug Hypersensitivity
- Food Allergy
- Mastocytosis and Mast Cell Activation Syndrome
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Immunodeficiency DisordersImmunodeficiency disorders are associated with or predispose patients to various complications, including infections, autoimmune disorders, and lymphomas and other cancers. Primary immunodeficiencies are genetically determined and can be hereditary; secondary immunodeficiencies are acquired and much more common.
- Overview of Immunodeficiency Disorders
- Approach to the Patient With Suspected Immunodeficiency
- Ataxia-Telangiectasia
- Chédiak-Higashi Syndrome
- Chronic Granulomatous Disease (CGD)
- Chronic Mucocutaneous Candidiasis
- Common Variable Immunodeficiency (CVID)
- DiGeorge Syndrome
- Hyper-IgE Syndrome
- Hyper-IgM Syndrome
- Selective IgA Deficiency
- Leukocyte Adhesion Deficiency
- Selective Antibody Deficiency With Normal Immunoglobulins (SADNI)
- Severe Combined Immunodeficiency (SCID)
- Transient Hypogammaglobulinemia of Infancy
- Wiskott-Aldrich Syndrome
- X-linked Agammaglobulinemia
- X-linked Lymphoproliferative Syndrome
- ZAP-70 Deficiency
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TransplantationTransplants may be
- Overview of Transplantation
- Heart Transplantation
- Hematopoietic Stem Cell Transplantation
- Kidney Transplantation
- Liver Transplantation
- Lung and Heart-Lung Transplantation
- Pancreas Transplantation
- Pancreatic Islet Cell Transplantation
- Small-Bowel Transplantation
- Tissue Transplantation
