Merck Manual

Please confirm that you are a health care professional

honeypot link

Introduction to Concepts in Pharmacotherapy

By

Shalini S. Lynch

, PharmD, University of California San Francisco School of Pharmacy

Last full review/revision Jun 2019| Content last modified Jun 2019
Click here for Patient Education

Drugs are selected based on characteristics of the drug (eg, efficacy Drug Efficacy and Safety Obviously, a drug (or any medical treatment) should be used only when it will benefit a patient. Benefit takes into account both the drug's ability to produce the desired result (efficacy) and... read more , safety profile Drug Efficacy and Safety Obviously, a drug (or any medical treatment) should be used only when it will benefit a patient. Benefit takes into account both the drug's ability to produce the desired result (efficacy) and... read more , route of administration Drug Absorption Drug absorption is determined by the drug’s physicochemical properties, formulation, and route of administration. Dosage forms (eg, tablets, capsules, solutions), consisting of the drug plus... read more , route of elimination Drug Excretion The kidneys are the principal organs for excreting water-soluble substances. The biliary system contributes to excretion to the degree that drug is not reabsorbed from the gastrointestinal ... read more , dosing frequency, cost Economic Analyses in Clinical Decision Making Given limited societal and personal resources and restrictions under health insurance, cost considerations have become more relevant in clinical decision making. Limited resources should not... read more ) and of the patient (eg, age, sex, other medical problems, likelihood of pregnancy, ethnicity, other genetic determinants). Risks and benefits of the drug are also assessed; every drug poses some risk.

Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Test your knowledge

Pharmacogenetics
The activity of drug-metabolizing enzymes often varies widely among healthy people, making metabolism highly variable. Which of the following factors is a major contributor to this variation?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID

Also of Interest

Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
TOP