Merck Manual

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Palmoplantar Keratodermas

By

James G. H. Dinulos

, MD, Geisel School of Medicine at Dartmouth

Last review/revision May 2021 | Modified Sep 2022
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Palmoplantar keratodermas are rare inherited disorders characterized by palmar and plantar hyperkeratosis.

Palmoplantar keratodermas encompass a broad range of inherited disorders. They may be categorized based on degree of skin involvement (eg, localized to the palms and soles, expanding to involve other cutaneous sites and adnexal structures) and on whether they are part of a recognizable syndrome that affects other organs, such as the eyes and ears. Secondary infections are common. Examples include the following:

Treatment of Palmoplantar Keratodermas

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