Esophageal Rupture

ByKristle Lee Lynch, MD, Perelman School of Medicine at The University of Pennsylvania
Reviewed/Revised Feb 2024
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Esophageal rupture may be iatrogenic during endoscopic procedures or other instrumentation or may be spontaneous (Boerhaave syndrome). Patients are seriously ill, with symptoms of mediastinitis. Diagnosis is by esophagography with a water-soluble contrast agent. Immediate surgical repair and drainage are required.

(See also Overview of Esophageal and Swallowing Disorders.)

Endoscopic procedures are the primary cause of esophageal rupture, but spontaneous rupture may occur, typically related to vomiting, retching, or swallowing a large food bolus.

Spontaneous rupture is especially likely in patients who have untreated eosinophilic esophagitis.

The most common site of rupture is the distal esophagus on the left side. Acid and other stomach contents cause a fulminant mediastinitis and shock. Pneumomediastinum is common.

Symptoms and Signs of Esophageal Rupture

Symptoms of esophageal rupture include chest and abdominal pain, fever, vomiting, hematemesis, and shock.

Subcutaneous emphysema is palpable in some patients.

Mediastinal crunch (Hamman sign), a crackling sound synchronous with the heartbeat, may be present.

Diagnosis of Esophageal Rupture

  • Chest and abdominal radiographs

  • Esophagography

Chest and abdominal radiographs showing mediastinal air, pleural effusion, or mediastinal widening suggest the diagnosis.

Diagnosis of esophageal rupture is confirmed by esophagography with a water-soluble contrast agent, which avoids potential mediastinal irritation from barium. CT of the thorax detects mediastinal air and fluid but does not localize the perforation well. Endoscopy may miss a small perforation.

Treatment of Esophageal Rupture

  • Endoscopic stenting or surgical repair

Even with treatment, mortality is high.

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