Merck Manual

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Renal Glucosuria

(Renal Glycosuria)

By

L. Aimee Hechanova

, MD, Texas Tech University Health Sciences Center, El Paso

Last full review/revision May 2022
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Renal glucosuria is the excretion of glucose in the urine in the presence of normal plasma glucose levels.

Renal glucosuria can be inherited. This form usually involves a reduction in the glucose transport maximum (the maximum rate at which glucose can be resorbed) and subsequent escape of glucose in the urine. The inherited disorder is usually transmitted as an incompletely recessive trait (heterozygotes have modest glucosuria).

Symptoms and Signs of Renal Glucosuria

Renal glucosuria is asymptomatic and without serious sequelae. However, if there is an associated generalized defect in proximal tubular function, symptoms and signs may include hypophosphatemic rickets, volume depletion, short stature, muscle hypotonia, and ocular changes of cataracts or glaucoma (oculocerebrorenal syndrome) or Kayser-Fleischer rings (Wilson disease). With such findings, transport defects other than glucosuria should be sought.

Diagnosis of Renal Glucosuria

  • Urinalysis

The disorder is typically initially noted on routine urinalysis, and is defined as glucosuria in the absence of hyperglycemia (serum glucose <140 mg/dL).

Some experts require a normal result on an oral glucose tolerance test for the diagnosis.

Treatment of Renal Glucosuria

  • No treatment needed

Isolated renal glucosuria is benign; no treatment is necessary.

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NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
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