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Overview of Histiocytic Disorders

By

Jeffrey M. Lipton

, MD, PhD, Zucker School of Medicine at Hofstra/Northwell;


Carolyn Fein Levy

, MD, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell

Last full review/revision Dec 2021
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Topic Resources

The histiocytic disorders are clinically heterogeneous disorders that result from an abnormal proliferation of histiocytes that are either

  • Dendritic cells (antigen-presenting cells)

  • Monocyte-macrophages (antigen-processing cells)

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General references

  • 1. Emile JF, Abla O, Fraitag S, et al: Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood 127(22):2672–2681, 2016. doi: 10.1182/blood-2016-01-690636

  • 2. Höck, M., Zelger, B., Schweigmann, G. et al: The various clinical spectra of juvenile xanthogranuloma: Imaging for two case reports and review of the literature. BMC Pediatr 19, 128 ,2019. doi: 10.1186/s12887-019-1490-y

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