Merck Manual

Please confirm that you are a health care professional

honeypot link

Overview of Histiocytic Disorders

By

Jeffrey M. Lipton

, MD, PhD, Zucker School of Medicine at Hofstra/Northwell;


Carolyn Fein Levy

, MD, Hofstra Northwell School of Medicine

Last full review/revision Jul 2019| Content last modified Jul 2019
Click here for Patient Education
Topic Resources

The histiocytic disorders are clinically heterogeneous disorders that result from an abnormal proliferation of histiocytes that are either

  • Monocyte-macrophages (antigen-processing cells)

  • Dendritic cells (antigen-presenting cells)

Classifying histiocytic disorders is difficult (see table Histiocytic Disorders Histiocytic Disorders The histiocytic disorders are clinically heterogeneous disorders that result from an abnormal proliferation of histiocytes that are either Monocyte-macrophages (antigen-processing cells) Dendritic... read more Histiocytic Disorders ) and has changed over time as an understanding of the biology of these cells has evolved. Langerhans cell histiocytosis Langerhans Cell Histiocytosis Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. Most cases occur in children. Manifestations may include... read more Langerhans Cell Histiocytosis is the most common histiocytic disorder. There are other rare histiocytic disorders such as Erdheim-Chester disease and juvenile xanthogranuloma, some of which are now considered variants of Langerhans cell histiocytosis.

Table
icon
Click here for Patient Education
NOTE: This is the Professional Version. CONSUMERS: Click here for the Consumer Version
Professionals also read

Test your knowledge

Eosinophilia
Eosinophilia is defined as a peripheral blood eosinophil count of > 500/mcL. The most common causes of eosinophilia are allergic or atopic disorders. Other causes include solid or hematologic tumors. In which of the following hematologic tumors is eosinophilia most marked?
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
Download the Manuals App iOS ANDROID
 

Also of Interest

 
TOP