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Thrombocytopenia Due to Splenic Sequestration


David J. Kuter

, MD, DPhil, Harvard Medical School

Last full review/revision Jun 2020| Content last modified Jun 2020
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The platelet count usually is > 30,000/mcL unless the disorder causing splenomegaly also impairs platelet production (eg, in myelofibrosis with myeloid metaplasia).

Sequestered platelets are released from the spleen at times of stress. Therefore, thrombocytopenia caused only by splenic sequestration rarely causes bleeding.

In patients with normal hepatic function, splenectomy corrects the thrombocytopenia; however, splenectomy is not indicated unless severe thrombocytopenia due to simultaneous bone marrow failure is present.

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