Mupirocin inhibits bacterial RNA and protein synthesis. It is available only as a 2% topical preparation, which is bactericidal against staphylococci Staphylococcal Infections Staphylococci are gram-positive aerobic organisms. Staphylococcus aureus is the most pathogenic; it typically causes skin infections and sometimes pneumonia, endocarditis, and osteomyelitis... read more and beta-hemolytic streptococci Streptococcal Infections Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. Symptoms vary with the organ... read more . Systemic absorption of topical mupirocin is negligible.
Mupirocin is used for
Chronic therapy leads to mupirocin-resistant staphylococci.
Mupirocin is nontoxic but, when applied to denuded skin or mucous membranes, may cause itching and burning.
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