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Quinupristin and Dalfopristin

By

Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last full review/revision May 2020
Click here for Patient Education

Quinupristin/dalfopristin (Q/D) is given together in a fixed 30/70 combination; this combination has synergistic bactericidal activity against the following:

Q/D is given via a central IV catheter because phlebitis frequently occurs when Q/D is given via a peripheral vein. Up to 30% of patients develop significant myalgias.

Dosage reduction is required for severe hepatic insufficiency but not for renal insufficiency.

Safety Warning

Q/D may inhibit the metabolism of drugs that are metabolized by the cytochrome P-450 (CYP450) 3A4 isoenzyme system.

Drugs Mentioned In This Article

Drug Name Select Trade
No US brand name
CLEOCIN
CUBICIN
FLAGYL
MONUROL
ZYVOX
VIBATIV
DALVANCE
SIVEXTRO
ORBACTIV
BACTROBAN
AZACTAM
VANCOCIN
TINDAMAX
FORTAZ, TAZICEF
ZITHROMAX
BIAXIN
ERY-TAB, ERYTHROCIN
DIFICID
No US brand name
No US brand name
GENOPTIC
ANCEF, KEFZOL
FURADANTIN, MACROBID, MACRODANTIN
KEFLEX
THAM
No US brand name
CEFOTAN
MEFOXIN
No US brand name
CEFTIN, ZINACEF
No US brand name
No US brand name
SUPRAX
CLAFORAN
No US brand name
No US brand name
No US brand name
MAXIPIME
No US brand name
BACIIM
TYGACIL
ACHROMYCIN V
MINOCIN
BICILLIN L-A
No US brand name
PRIMSOL
MYCOBUTIN
VIBRAMYCIN
XERAVA
RIFADIN, RIMACTANE
No US brand name
PRIFTIN
XIFAXAN
DORIBAX
INVANZ
MERREM
AMOXIL
SULFAMYLON
No US brand name
BLEPH-10
No US brand name
NALLPEN IN PLASTIC CONTAINER
BACTOCILL IN PLASTIC CONTAINER
AZULFIDINE
BACTRIM, SEPTRA
DARAPRIM
SILVADENE
QUALAQUIN
CILOXAN, CIPRO
No US brand name
ZEMDRI
No US brand name
TOBI, TOBREX
No US brand name
NUZYRA
No US brand name
COLY-MYCIN M
ARALEN
PROGRAF
TIKOSYN
SEROQUEL
LANOXIN
OZURDEX
DILANTIN
LANIAZID
No US brand name
NARDIL
MARPLAN
DEMEROL
WELLBUTRIN, ZYBAN
No US brand name
SYNERCID
PROZAC, SARAFEM
ELIXOPHYLLIN
ANTABUSE
COUMADIN
ACZONE
No US brand name
No US brand name
OCUFLOX
AFRINOL, SUDAFED
ADRENALIN
LEVOPHED
BAXDELA
FACTIVE
LEVAQUIN
AVELOX
No US brand name
No US brand name
ZYMAR
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