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Quinupristin and Dalfopristin


Brian J. Werth

, PharmD, University of Washington School of Pharmacy

Last review/revision May 2022 | Modified Sep 2022
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Quinupristin/dalfopristin (Q/D) is given together in a fixed 30/70 combination; this combination has synergistic bactericidal activity against the following:

Q/D is given via a central IV catheter because phlebitis frequently occurs when Q/D is given via a peripheral vein. Up to 30% of patients develop significant myalgias. Q/D may cause hyperbilirubinemia.

Dosage reduction is required for severe hepatic insufficiency but not for renal insufficiency.

Safety Warning

Q/D may inhibit the metabolism of drugs that are metabolized by the cytochrome P-450 (CYP450) 3A4 isoenzyme system.

Drugs Mentioned In This Article

Drug Name Select Trade
Vancocin, Vancocin Powder, VANCOSOL
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NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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