Merck Manual

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Trench Fever

(Wolhynia Fever; Shin Bone Fever; Quintan Fever)


Larry M. Bush

, MD, FACP, Charles E. Schmidt College of Medicine, Florida Atlantic University;

Maria T. Vazquez-Pertejo

, MD, FACP, Wellington Regional Medical Center

Reviewed/Revised Apr 2022 | Modified Sep 2022

Trench fever is a louse-borne disease caused by the gram-negative bacterium Bartonella quintana and observed originally in military populations during World Wars I and II. Symptoms are an acute, recurring febrile illness, occasionally with a rash. Diagnosis is by blood culture. Treatment is with a macrolide or doxycycline.

Humans are the only reservoir of this Bartonella infection. B. quintana is transmitted to humans when feces from infected lice are rubbed into abraded skin or the conjunctiva.

Trench fever is endemic in Mexico, Tunisia, Eritrea, Poland, and the former Soviet Union and is reappearing in the homeless population in the US.

Symptoms and Signs of Trench Fever

After a 14- to 30-day incubation period, onset of trench fever is sudden, with fever, weakness, dizziness, headache (with pain behind the eyes), conjunctival injection, and severe back and leg (shin) pains.

Fever may reach 40.5° C and persist for 5 to 6 days. In about half the cases, fever recurs 1 to 8 times at 5- to 6-day intervals.

Relapses are common and have occurred up to 10 years after the initial attack.

Diagnosis of Trench Fever

  • Blood cultures

  • Serologic tests and polymerase chain reaction (PCR) testing

Trench fever should be suspected in people living where louse infestation is heavy.

The organism is identified by blood culture, although growth may take 1 to 4 weeks. The disease is marked by persistent bacteremia Bacteremia Bacteremia is the presence of bacteria in the bloodstream. It can occur spontaneously, during certain tissue infections, with use of indwelling genitourinary or IV catheters, or after dental... read more during the initial attack, during relapses, throughout the asymptomatic periods between relapses, and in patients with endocarditis.

Serologic testing is available and can provide support for the diagnosis. High titers of IgG antibodies should trigger evaluation for endocarditis Diagnosis Infective endocarditis is infection of the endocardium, usually with bacteria (commonly, streptococci or staphylococci) or fungi. It may cause fever, heart murmurs, petechiae, anemia, embolic... read more Diagnosis with cardiac echocardiography. PCR testing of blood or tissue samples can be done.

Treatment of Trench Fever

  • Doxycycline or a macrolide

Although recovery is usually complete in 1 to 2 months and mortality is negligible, bacteremia may persist for months after clinical recovery, and prolonged (> 1 month) doxycycline or macrolide treatment may be needed. Patients are given doxycycline 100 mg orally 2 times a day for 4 to 6 weeks, plus, if endocarditis is suspected, gentamicin 3 mg/kg/day IV for the initial 2 weeks. Combination therapy is given for serious or complicated infections.

Patients with chronic bacteremia should be monitored for signs of endocarditis.

Drugs Mentioned In This Article

Drug Name Select Trade
Acticlate, Adoxa, Adoxa Pak, Avidoxy, Doryx, Doxal, Doxy 100, LYMEPAK, Mondoxyne NL, Monodox, Morgidox 1x, Morgidox 2x , Okebo, Oracea, Oraxyl, Periostat, TARGADOX, Vibramycin, Vibra-Tabs
Garamycin, Genoptic, Genoptic SOP, Gentacidin, Gentafair, Gentak , Gentasol, Ocu-Mycin
NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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