Sequential Organ Failure Assessment (SOFA) Score

Parameter

Score: 0

Score: 1

Score: 2

Score: 3

Score: 4

PaO2/FIO2

400 mm Hg (53.3 kPa)

< 400 mm Hg (53.3 kPa)

< 300 mm Hg (40 kPa)

< 200 mm Hg (26.7 kPa) with respiratory support

< 100 mm Hg (13.3 kPa) with respiratory support

Platelets

150 × 103/mcL ( 150 × 109/L)

< 150 × 103/mcL (< 150 × 109/L)

< 100 × 103/mcL (< 100 × 109/L)

< 50 × 103/mcL (< 50 × 109/L)

< 20 × 103/mcL (< 20 × 109/L)

Bilirubin

< 1.2 mg/dL (20 micromole/L)

1.2–1.9 mg/dL (20–32 micromole/L)

2.0–5.9 mg/dL (33–101 micromole/L)

6.0–11.9 mg/dL (102–204 micromole/L)

> 12.0 mg/dL (204 micromole/L)

Cardiovascular (with medication doses given for 1 hour)

MAP 70 mm Hg

MAP < 70 mm Hg

< 5 mcg/kg/minute

or

or

0.1 mcg/kg/minute

or

0.1 mcg/kg/minute

> 15 mcg/kg/minute

or

> 0.1 mcg/kg/minute

or

> 0.1 mcg/kg/minute

Glasgow Coma Scale score*

15 points

13–14 points

10–12 points

6–9 points

< 6 points

Creatinine

< 1.2 mg/dL (110 micromole/L)

1.2-1.9 mg/dL (110–170 micromole/L)

2.0-3.4 mg/dL (171–299 micromole/L)

3.5-4.9 mg/dL (300–400 micromole/L)

> 5.0 mg/dL (440 micromole/L)

Urine output

< 500 mL/day

< 200 mL/day

* A higher score indicates better neurologic function.

FIO2 = fraction of inspired oxygen; kPa = kilopascals; MAP = mean arterial pressure; PaO2 = arterial oxygen partial pressure.

Adapted from Singer M, Deutschman CS, Seymour CW, et al: The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801–810, 2016. doi:10.1001/jama.2016.0287