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Prosthetic Joint Infectious Arthritis


Steven Schmitt

, MD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Last full review/revision Sep 2020| Content last modified Sep 2020
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Prosthetic joints are at risk of acute and chronic infection, which can cause sepsis, morbidity, or mortality. Patients often have a history of a recent fall. Symptoms include joint pain, swelling, and limited motion. Diagnosis is based on various criteria. Treatment is prolonged antibiotic therapy and usually arthrotomy.


Infections are more common in prosthetic joints than in natural joints. They are frequently caused by perioperative inoculations of bacteria into the joint or by postoperative bacteremia resulting from skin infection, pneumonia, dental procedures, invasive instrumentation, urinary tract infection, or possibly falls.

Joint infections develop within 1 year of surgery in two thirds of cases. During the first few months after surgery, the causes are Staphylococcus aureus Staphylococcal Infections Staphylococci are gram-positive aerobic organisms. Staphylococcus aureus is the most pathogenic; it typically causes skin infections and sometimes pneumonia, endocarditis, and osteomyelitis... read more Staphylococcal Infections in 50% of cases, mixed flora in 35%, gram-negative organisms in 10%, and anaerobes in 5%. Propionibacterium acnes is especially common in infected prosthetic shoulder joints and may require prolonged culture (up to 2 weeks) to detect. Candida Candidiasis (Invasive) Candidiasis is infection by Candida species (most often C. albicans), manifested by mucocutaneous lesions, fungemia, and sometimes focal infection of multiple sites. Symptoms depend on the site... read more Candidiasis (Invasive) spp infect prosthetic joints in < 5% of cases.

Symptoms and Signs

There is a history of a fall within 2 weeks of symptom onset in about 25% of patients and of prior surgical revisions in about 20%.

Some patients have had a postoperative wound infection that appeared to resolve, satisfactory postoperative recovery for many months, and then development of persistent joint pain at rest and during weight bearing.

Symptoms and signs of prosthetic joint infectious arthritis may include pain, swelling, and limited motion; temperature may be normal.


  • Clinical, microbiologic, pathologic, and imaging criteria

The diagnosis of infection in a prosthetic joint often requires a combination of clinical, microbiologic, pathologic, and imaging criteria. Communication between a sinus tract and the prosthesis may also be considered diagnostic of infection.

Synovial fluid should be sampled for cell count and culture. X-rays may show loosening of the prosthesis or periosteal reaction but are not diagnostic. Technetium-99m bone scanning and indium-labeled white blood cell scanning are more sensitive than plain x-rays but lack specificity in the immediate postoperative period. Ultimately, periprosthetic tissue collected at the time of surgery may be sent for culture and histologic analysis.


  • Arthrotomy with debridement

  • Long-term systemic antibiotic therapy

Treatment of prosthetic joint infection must be prolonged and usually involves arthrotomy for prosthesis removal with meticulous debridement of all cement, abscesses, and devitalized tissues. Debridement is followed by immediate prosthesis revision or placement of an antibiotic-impregnated spacer and then delayed (2 to 4 months) implantation of a new prosthesis using antibiotic-impregnated cement.

Long-term systemic antibiotic therapy is used in either case; empiric therapy is initiated after intraoperative culture is done and usually combines coverage for methicillin-resistant gram-positive organisms (eg, vancomycin 1 g IV every 12 hours) and aerobic gram-negative organisms (eg, piperacillin/tazobactam 3.375 g IV every 6 hours or ceftazidime 2 g IV every 8 hours) and is revised based on results of culture and sensitivity testing.

Infection develops in 38% of replacement prostheses, whether replaced immediately or after delay.

If patients cannot tolerate surgery, long-term antibiotic therapy alone can be tried. Excision arthroplasty with or without fusion usually is reserved for patients with uncontrolled infection and insufficient bone stock.


In the absence of other indications (eg, valvular heart disease), whether patients with prosthetic joints need prophylactic antibiotics before procedures such as dental work and urologic instrumentation is currently unresolved. See guidelines from the American Academy of Orthopaedic Surgeons (AAOS) and the American Dental Association (ADA) for the prevention of orthopedic implant infection in patients undergoing dental procedures.

At many centers, patients are screened for S. aureus colonization using nasal cultures. Carriers are decolonized with mupirocin ointment before surgery to implant a prosthetic joint.

More Information

The following English-language resources may be useful. Please note that THE MANUAL is not responsible for the content of these resources.

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