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Childhood Vaccination Schedule


Michael J. Smith

, MD, MSCE, Duke University School of Medicine

Last full review/revision Nov 2021| Content last modified Dec 2021
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Practitioners should also check the CDC's latest recommendations (also available as a free mobile app), consult the CDC's child–adolescent immunization schedules and catch-up immunization schedule, and consult the relevant Advisory Committee on Immunization Practices (ACIP) statements for detailed recommendations and updates. Vaccination status should be reassessed at every visit.


COVID-19 vaccination in children

In addition to the immunizations noted in the immunization schedules, children in the US in certain age groups are now eligible for COVID-19 vaccination COVID-19 Vaccine COVID-19 vaccines provide protection against COVID-19. COVID-19 is the disease caused by infection with the SARS-CoV-2 virus. There are multiple COVID-19 vaccines currently in use worldwide... read more . The Pfizer-BioNTech COVID-19 vaccine (mRNA) has received an Emergency Use Authorization (EUA) for children 5 to 15 years of age and is approved for use in people 16 years of age and older. The Pfizer vaccine dose for ages 12 or older is 0.3 mL (30 mcg) IM, given in a primary 2-dose series 3 weeks apart. The Pfizer vaccine dose for ages 5 to 11 is 0.2 mL (10 mcg) IM, also given in a primary 2-dose series 3 weeks apart. EUA has also been granted for an additional primary dose, given at least 28 days after the second dose, for people 12 years of age and older who have moderatly to severely immunocompromising conditions.

People 16 and 17 years of age who completed their initial 2-dose series (or their third primary dose, if immunocompromised) of the Pfizer vaccine 6 or more months ago are eligible for a booster dose of the Pfizer vaccine only. Unlike people 18 years of age and older who can choose any available COVID-19 vaccine as a booster shot, only a Pfizer booster shot is available to eligible people 16 and 17 years of age.

People 16 and 17 years of age who received the Moderna or Johnson & Johnson primary dose series are not eligible for a booster shot. (See COVID-19 Vaccine Booster Shots.)

COVID-19 vaccine may be given at the same time as routine immunizations.

  • Severe allergic reaction to a previous dose

  • Severe allergic reaction to a vaccine component

  • An immediate allergic reaction of any severity to a previous dose or known (diagnosed) allergy to a component of the vaccine

Polyethylene glycol (PEG) is used in mRNA vaccines and is the most commonly implicated allergen.

The Moderna COVID-19 vaccine (mRNA) is also being studied for use in children under 18 years of age but does not currently have approval or EUA.

COVID-19 vaccination in children reference

Malaria vaccination in children

On October 6, 2021, the World Health Organization (WHO) recommended widespread use of the RTS,S/AS01 (RTS,S) malaria vaccine among children in sub-Saharan Africa and in other regions with moderate to high Plasmodium falciparum malaria transmission. (See WHO recommends groundbreaking malaria vaccine for children at risk.)

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