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Bladder Anomalies

By

Ronald Rabinowitz

, MD, University of Rochester Medical Center;


Jimena Cubillos

, MD, University of Rochester School of Medicine and Dentistry

Last full review/revision Sep 2020| Content last modified Sep 2020
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Congenital urinary bladder anomalies often occur without other genitourinary abnormalities. They may cause infection, retention, incontinence, and reflux. Symptomatic anomalies may require surgery.

Bladder diverticulum

Diagnosis of bladder diverticulum is by voiding cystourethrography.

Surgical removal of the diverticulum and reconstruction of the bladder wall may be necessary.

Bladder exstrophy

In exstrophy, there is a failure of midline closure from the umbilicus to the perineum, resulting in bladder mucosa continuity with the abdominal skin, separation of the pubic symphysis, and epispadias Epispadias Congenital anomalies of the urethra in boys usually involve anatomic abnormalities of the penis and vice versa. In girls, urethral anomalies may exist without other external genital abnormalities... read more Epispadias or bifid genitalia. The bladder is open suprapubically, and urine drips from the open bladder rather than through the urethra. Despite the seriousness of the deformity, normal renal function usually is maintained.

The bladder can usually be reconstructed and returned to the pelvis, although vesicoureteral reflux invariably occurs and is managed as needed. Additional surgical intervention may be necessary to treat a bladder reservoir that fails to expand sufficiently or has sphincter insufficiency. Reconstruction of the genitals is required.

Megacystis syndrome

In this syndrome, a large, thin-walled, smooth bladder without evident outlet obstruction develops, usually in girls. Megacystis syndrome is poorly understood. The syndrome may be a manifestation of a primary myoneural defect, especially when intestinal obstruction (eg, megacystis-microcolon, intestinal hypoperistalsis syndrome) is also present.

Ultrasonography with the bladder empty may disclose normal-appearing upper tracts, but voiding cystourethrography may show reflux with massive upper tract dilation.

Ureteral reimplantation may be effective, although some patients benefit from antibacterial prophylaxis, timed voiding with behavioral modification, intermittent catheterization, or a combination.

Neurogenic bladder

Neurogenic bladder Neurogenic Bladder Neurogenic bladder is bladder dysfunction (flaccid or spastic) caused by neurologic damage. Symptoms can include overflow incontinence, frequency, urgency, urge incontinence, and retention.... read more is bladder dysfunction caused by neurologic disorders, including spinal cord or central nervous system abnormalities, trauma, or the sequelae of pelvic surgery (eg, for sacrococcygeal teratoma or imperforate anus Anal Atresia Anal atresia is an imperforate anus. (Also see Overview of Congenital Gastrointestinal Anomalies.) In anal atresia, the tissue closing the anus may be several centimeters thick or just a thin... read more ). The bladder may be flaccid, spastic, or a combination. A flaccid bladder has high-volume, low-pressure, and minimal contractions. A spastic bladder has normal or low-volume, high-pressure, and involuntary contractions. When present, chronically elevated bladder pressure (> 40 cm H2O) often causes progressive kidney damage, even without infection or reflux.

The underlying neurologic abnormality is usually readily apparent. Usually, postvoiding residual volume is measured, renal ultrasonography is done to detect hydronephrosis, and serum creatinine is measured to assess renal function. Urodynamic testing is often done to confirm diagnosis and to monitor bladder pressures and function. These studies are often repeated at scheduled intervals as the child grows to assess for deterioration of bladder and renal function.

Management goals include lowering risk of infection, maintaining adequate bladder storage pressure and volume, effective bladder emptying, and achieving social continence. Treatment of neurogenic bladder includes drugs (eg, anticholinergics, prophylactic antibiotics), intermittent catheterization, and/or surgical intervention (eg, augmentation cystoplasty, appendicovesicostomy, botulinum toxin injections, neurostimulation). Children with neurogenic bladder often also have a neurogenic bowel with constipation Constipation in Children Constipation is responsible for up to 5% of pediatric office visits. It is defined as delay or difficulty in defecation. Normal frequency and consistency of stool varies with children's age... read more and stool incontinence Stool Incontinence in Children Stool incontinence is the voluntary or involuntary passage of stool in inappropriate places in children > 4 years of age (or developmental equivalent) who do not have an organic defect or illness... read more that also require proper management.

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