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Niemann-Pick Disease


Matt Demczko

, MD, Sidney Kimmel Medical College of Thomas Jefferson University

Last full review/revision Apr 2020| Content last modified Apr 2020
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Niemann-Pick disease is a sphingolipidosis, an inherited disorder of metabolism, caused by deficient sphingomyelinase activity, resulting in accumulation of sphingomyelin (ceramide phosphorylcholine) in reticuloendothelial cells. Diagnosis is by DNA analysis and/or enzyme analysis of white blood cells. Bone marrow transplantation, stem cell transplantation, and enzyme replacement may be treatment options.

For more information, see table Some Sphingolipidoses and see table Other Lipidoses.

Niemann-Pick disease inheritance is autosomal recessive and appears most often in Ashkenazi Jews; 2 types, A and B, exist. Type C Niemann-Pick disease is an unrelated enzymatic defect involving abnormal cholesterol storage.

Children with type A have < 5% of normal sphingomyelinase activity. The disease is characterized by hepatosplenomegaly, failure to thrive, and rapidly progressive neurodegeneration. Death occurs by age 2 or 3 years.

Patients with type B have sphingomyelinase activity within 5 to 10% of normal. Type B is more variable clinically than type A. Hepatosplenomegaly and lymphadenopathy may occur. Pancytopenia is common. Most patients with type B have little or no neurologic involvement and survive into adulthood; they may be clinically indistinguishable from those with type I Gaucher disease. In severe cases of type B, progressive pulmonary infiltrates cause major complications.


  • Prenatal screening

  • white blood cell sphingomyelinase assay

Both types are usually suspected by history and examination, most notably hepatosplenomegaly. Diagnosis of Niemann-Pick disease can be confirmed by DNA analysis and/or sphingomyelinase assay on white blood cells and can be made prenatally by using amniocentesis or chorionic villus sampling. DNA tests also can be done to diagnose carriers. (Also see testing for suspected inherited disorders of metabolism.)


  • Possible bone marrow transplantation, stem cell transplantation, and enzyme replacement

Bone marrow transplantation, stem cell transplantation, and enzyme replacement are under investigation as potential treatment options.

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