The cause of postmaturity is generally unknown, but previous postterm delivery increases the risk 2- to 3-fold. Postmaturity may be caused by abnormalities that affect the fetal pituitary-adrenal axis (eg, anencephaly Anencephaly Anencephaly is absence of the cerebral hemispheres. It is usually accompanied by a defect in the formation of the skull posteriorly, leaving the back of the head without skeletal protection... read more , adrenal gland hypoplasia, congenital adrenal hyperplasia Overview of Congenital Adrenal Hyperplasia Congenital adrenal hyperplasia is a group of genetic disorders, each characterized by inadequate synthesis of cortisol, aldosterone, or both. In the most common forms, accumulated hormone precursors... read more ) and by x-linked ichthyosis Inherited ichthyoses Ichthyosis is scaling and flaking of skin ranging from mild but annoying dryness to severe disfiguring disease. Ichthyosis can also be a sign of systemic disease. Diagnosis is clinical. Treatment... read more 
associated with placental sulfatase deficiency.
Pathophysiology of Postterm Infants
In most cases, fetal growth continues until delivery. However, in some cases, the placenta involutes as pregnancy progresses and multiple infarcts and villous degeneration develop, causing placental insufficiency. In these cases, the fetus receives inadequate nutrients and oxygen from the mother, resulting in a thin (due to soft-tissue wasting), undernourished infant with depleted glycogen stores and decreased amniotic fluid volume. Such infants are dysmature and, depending on when placental insufficiency develops and the severity of the condition, they may be small-for-gestational-age Small-for-Gestational-Age (SGA) Infant Infants whose weight is < the 10th percentile for gestational age are classified as small for gestational age. Complications include perinatal asphyxia, meconium aspiration, polycythemia... read more . Although placental insufficiency with dysmaturity can occur at any gestational age, it is most common in pregnancies that progress beyond 41 to 42 weeks.
Complications
Postterm infants have higher morbidity and mortality than term infants due in large part to
Perinatal asphyxia
Meconium aspiration syndrome
Neonatal hypoglycemia
Perinatal asphyxia may result from placental insufficiency as well as cord compression secondary to oligohydramnios.
Meconium aspiration syndrome Meconium Aspiration Syndrome Intrapartum meconium aspiration can cause inflammatory pneumonitis and mechanical bronchial obstruction, causing a syndrome of respiratory distress. Findings include tachypnea, rales and rhonchi... read more may be unusually severe because amniotic fluid volume is decreased and thus the aspirated meconium is less dilute. Persistent pulmonary hypertension Persistent Pulmonary Hypertension of the Newborn Persistent pulmonary hypertension of the newborn is the persistence of or reversion to pulmonary arteriolar constriction, causing a severe reduction in pulmonary blood flow and right-to-left... read more often occurs after meconium aspiration.
Neonatal hypoglycemia Neonatal Hypoglycemia Hypoglycemia is difficult to define in neonates but is generally considered a serum glucose concentration < 40 mg/dL (< 2.2 mmol/L) in symptomatic term neonates, < 45 mg/dL (< 2... read more is a complication caused by insufficient glycogen stores or by increased production of insulin (most commonly caused by maternal diabetes) in the fetus. Because anaerobic metabolism rapidly uses the remaining glycogen stores, hypoglycemia is exaggerated if perinatal asphyxia has occurred.
Symptoms and Signs of Postterm Infants
Postterm infants are alert and appear mature. They have a decreased amount of soft-tissue mass, particularly subcutaneous fat. The skin may hang loosely on the extremities and is often dry and peeling. The fingernails and toenails are long. The nails, skin, and umbilical cord may be stained with meconium passed in utero.
Diagnosis of Postterm Infants
Gestational age and physical examination
Postterm is diagnosed based on the neonate's gestational age Gestational Age Gestational age and growth parameters help identify the risk of neonatal pathology. Gestational age is the primary determinant of organ maturity. Neonatal gestational age is usually defined... read more and physical examination findings.
Definitions of term pregnancy from the American College of Obstetricians and Gynecologists are (1 Diagnosis reference A postterm infant is an infant born at ≥ 42 weeks of gestation. The cause of postmaturity is generally unknown, but previous postterm delivery increases the risk 2- to 3-fold. Postmaturity may... read more )
Early term: 37 to 38 6/7 weeks
Full term: 39 to 40 6/7 weeks
Late term: 41 to 41 6/7 weeks
Postterm: ≥ 42 weeks
Diagnosis reference
1. ACOG Committee Opinion No 579: Definition of term pregnancy. Obstet Gynecol 122(5):1139-1140, 2013. doi: 10.1097/01.AOG.0000437385.88715.4a
Treatment of Postterm Infants
Treatment of complications
Improved obstetric care over the past 2 decades has markedly decreased the number of infants delivered past 41 weeks of gestation, which has also decreased the incidence of meconium aspiration syndrome.
Postterm and dysmature infants are at risk of hypoglycemia and should be monitored and managed accordingly.
For infants with perinatal asphyxia, management depends on the severity of the disease process. Therapeutic hypothermia may help infants with moderate or severe encephalopathy who had severe acidosis at birth, a low Apgar score at ≥ 5 minutes, and/or a need for prolonged resuscitation.
Neither the incidence nor the severity of meconium aspiration syndrome Meconium Aspiration Syndrome Intrapartum meconium aspiration can cause inflammatory pneumonitis and mechanical bronchial obstruction, causing a syndrome of respiratory distress. Findings include tachypnea, rales and rhonchi... read more is reduced by endotracheal suction at the time of delivery, regardless of the apparent viscosity of the fluid or the infant's level of activity, so endotracheal intubation should be reserved for infants who need ventilatory assistance or who seem to have obstruction of the airway caused by meconium. Infants with meconium aspiration syndrome may require assisted ventilation; high-frequency ventilation Mechanical Ventilation Initial stabilization maneuvers include mild tactile stimulation, head positioning, and suctioning of the mouth and nose followed as needed by Supplemental oxygen Continuous positive airway... read more is sometimes helpful. Sedation is often necessary.
Surfactant treatment does not decrease overall mortality but does reduce the likelihood of the need for treatment with extracorporeal membrane oxygenation Extracorporeal Membrane Oxygenation (ECMO) Initial stabilization maneuvers include mild tactile stimulation, head positioning, and suctioning of the mouth and nose followed as needed by Supplemental oxygen Continuous positive airway... read more (ECMO), so surfactant is frequently used in infants with significant respiratory distress. ECMO is available in a relatively few neonatal centers and generally is reserved for infants ≥ 34 weeks of gestation with hypoxic respiratory failure refractory to conventional medical treatment.
Persistent pulmonary hypertension Persistent Pulmonary Hypertension of the Newborn Persistent pulmonary hypertension of the newborn is the persistence of or reversion to pulmonary arteriolar constriction, causing a severe reduction in pulmonary blood flow and right-to-left... read more is treated with supportive therapies and inhaled nitric oxide or other pulmonary vasodilators.
