(See also Neonatal Pneumonia.)
An estimated 4 to 5 million people in the United States develop pneumonia each year, of whom about 55,000 die. In the United States, pneumonia, along with influenza, is the 8th leading cause of death and is the leading infectious cause of death. Pneumonia is the most common fatal hospital-acquired infection and the most common overall cause of death in developing countries.
The most common cause of pneumonia in adults > 30 years, in the absence of an ongoing viral pandemic such as COVID-19, is
Streptococcus pneumoniae is still the most common pathogen in all age groups, settings, and geographic regions. However, the incidence of S. pneumoniae infection has been declining because of increasing rates of vaccination and development of herd immunity. However, pathogens of every sort, from viruses to parasites, can cause pneumonia. With the availability of sensitive molecular diagnostic methods, there is increasing recognition of viruses as a cause of pneumonia.
The airways and lungs are constantly exposed to pathogens in the external environment; the upper airways and oropharynx in particular are colonized with so-called normal flora. Microaspiration of these pathogens from the upper respiratory tract is a regular occurrence, but these pathogens are readily dealt with by lung host defense mechanisms. Pneumonia develops when
Occasionally, infection develops when pathogens reach the lungs via the bloodstream or by contiguous spread from the chest wall or mediastinum. Another recently identified potential pathway of pneumonia development is dysbiosis in the resident microbiome of the lung.
Upper airway defenses include salivary IgA, proteases, and lysozyme; growth inhibitors produced by normal flora; and fibronectin, which coats the mucosa and inhibits adherence.
Nonspecific lower airway defenses, including cough and mucociliary clearance, prevent infection in airspaces. Specific lower airway defenses include various pathogen-specific immune mechanisms, including IgA and IgG opsonization, antimicrobial peptides, anti-inflammatory effects of surfactant, phagocytosis by alveolar macrophages, and T-cell–mediated immune responses. These mechanisms protect most people against infection.
Numerous conditions alter the normal flora (eg, systemic illness, undernutrition, hospital exposure, antibiotic exposure) or impair these defenses (eg, altered mental status, cigarette smoking, nasogastric or endotracheal intubation, disorders or drugs that suppress the immune system). Pathogens that then reach airspaces can multiply and cause pneumonia.
Specific pathogens causing pneumonia cannot be found in up to 50% of patients, even with extensive diagnostic investigation, primarily because of the limitations of currently available diagnostic tests and the difficulty of obtaining adequate deep lung (alveolar) samples. But because pathogens and outcomes tend to be similar in patients in similar settings and with similar risk factors, pneumonias can be categorized as
These categorizations allow treatment to be selected empirically.