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Dysphagia is difficulty swallowing. The condition results from impeded transport of liquids, solids, or both from the pharynx to the stomach. Dysphagia should not be confused with globus sensation (see Lump in Throat), a feeling of having a lump in the throat, which is unrelated to swallowing and occurs without impaired transport.
Dysphagia is classified as oropharyngeal or esophageal, depending on where it occurs.
Oropharyngeal dysphagia is difficulty emptying material from the oropharynx into the esophagus; it results from abnormal function proximal to the esophagus. Patients complain of difficulty initiating swallowing, nasal regurgitation, and tracheal aspiration followed by coughing.
Most often, oropharyngeal dysphagia occurs in patients with neurologic conditions or muscular disorders that affect skeletal muscles (see Some Causes of Oropharyngeal Dysphagia).
Some Causes of Oropharyngeal Dysphagia
Esophageal dysphagia is difficulty passing food down the esophagus. It results from either a motility disorder or a mechanical obstruction (see Some Causes of Esophageal Dysphagia).
Some Causes of Esophageal Dysphagia
History of present illness begins with duration of symptoms and acuity of onset. Patients should describe what substances cause difficulty and where they feel the disturbance is located. Specific concerns include whether patients have difficulty swallowing solids, liquids, or both; whether food comes out their nose; whether they drool or have food spill from their mouth; and whether they cough or choke while eating.
Review of symptoms should focus on symptoms suggestive of neuromuscular, GI, and connective tissue disorders and on the presence of complications. Important neuromuscular symptoms include weakness and easy fatigability, gait or balance disturbance, tremor, and difficulty speaking. Important GI symptoms include heartburn or other chest discomfort suggestive of reflux. Symptoms of connective tissue disorders include muscle and joint pain, Raynaud phenomenon, and skin changes (eg, rash, swelling, thickening).
Examination focuses on findings suggestive of neuromuscular, GI, and connective tissue disorders and on the presence of complications.
General examination should evaluate nutritional status (including body weight). A complete neurologic examination is essential, with attention to any resting tremor, the cranial nerves (note the gag reflex may normally be absent; this absence is thus not a good marker of swallowing dysfunction), and muscle strength. Patients who describe easy fatigability should be observed performing a repetitive action (eg, blinking, counting aloud) for a rapid decrement in performance. The patient’s gait should be observed, and balance should be tested. Skin is examined for rash and thickening or texture changes, particularly on the fingertips. Muscles are inspected for wasting and fasciculations and are palpated for tenderness. The neck is evaluated for thyromegaly or other mass.
Dysphagia that occurs in conjunction with an acute neurologic event is likely the result of that event; new dysphagia in a patient with a stable, long-standing neurologic disorder may have another etiology. Dysphagia for solids alone suggests mechanical obstruction; however, a problem with both solids and liquids is nonspecific. Drooling and spilling food from the mouth while eating or nasal regurgitation suggests an oropharyngeal disorder. Regurgitation of a small amount of food on lateral compression of the neck is virtually diagnostic of pharyngeal diverticulum.
Patients who complain of difficulty getting food to leave the mouth or of food sticking in the lower esophagus are usually correct about the condition’s location; the sensation of dysphagia in the upper esophagus is less specific.
Many findings suggest specific disorders (see Some Helpful Findings in Dysphagia) but are of varying sensitivity and specificity and thus do not rule in or out a given cause; however, they can guide testing.
Some Helpful Findings in Dysphagia
Patients with dysphagia should always have upper endoscopy, which is extremely important to rule out cancer. During endoscopy, esophageal biopsies should also be done to look for eosinophilic esophagitis. A barium swallow (with a solid bolus, usually a marshmallow or tablet) can be done if the patient is unable to undergo an upper endoscopy. If the barium swallow is negative and the upper endoscopy is normal, esophageal motility studies should be done. Other tests for specific causes are done as suggested by findings.
Treatment is directed at the specific cause. If complete obstruction occurs, emergent upper endoscopy is essential. If a stricture, ring, or web is found, careful endoscopic dilation is performed. Pending resolution, patients with oropharyngeal dysphagia may benefit from evaluation by a rehabilitation specialist. Sometimes patients benefit from changing head position while eating, retraining the swallowing muscles, doing exercises that improve the ability to accommodate a food bolus in the oral cavity, or doing strength and coordination exercises for the tongue. Patients with severe dysphagia and recurrent aspiration may require a gastrostomy tube.
Chewing, swallowing, tasting, and communicating require intact, coordinated neuromuscular function in the mouth, face, and neck. Oral motor function in particular declines measurably with aging, even in healthy people. Decline in function may have many manifestations:
Reduction in masticatory muscle strength and coordination is common, especially among patients with partial or complete dentures, and may lead to a tendency to swallow larger food particles, which can increase the risk of choking or aspiration.
Drooping of the lower face and lips caused by decreased circumoral muscle tone and, in edentulous people, reduced bone support, is an aesthetic concern and can lead to drooling, spilling of food and liquids, and difficulty closing the lips while eating, sleeping, or resting. Sialorrhea (saliva leakage) is often the first symptom.
Swallowing difficulties increase. It takes longer to move food from mouth to oropharynx, which increases the likelihood of aspiration.
After age-related changes, the most common causes of oral motor disorders are neuromuscular disorders (eg, cranial neuropathies caused by diabetes, stroke, Parkinson disease, amyotrophic lateral sclerosis, multiple sclerosis). Iatrogenic causes also contribute. Drugs (eg, anticholinergics, diuretics), radiation therapy to the head and neck, and chemotherapy can greatly impair saliva production. Hyposalivation is a major cause of delayed and impaired swallowing.
Oral motor dysfunction is best managed with a multidisciplinary approach. Coordinated referrals to specialists in prosthetic dentistry, rehabilitative medicine, speech pathology, otolaryngology, and gastroenterology may be needed.
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