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Carbohydrate intolerance is the inability to digest certain carbohydrates due to a lack of one or more intestinal enzymes. Symptoms include diarrhea, abdominal distention, and flatulence. Diagnosis is clinical and by an H 2 breath test. Treatment is removal of the causative disaccharide from the diet.
Disaccharides are normally split into monosaccharides by disaccharidases (eg, lactase, maltase, isomaltase, sucrase [invertase]) located in the brush border of small-bowel enterocytes. Undigested disaccharides cause an osmotic load that attracts water and electrolytes into the bowel, causing watery diarrhea. Bacterial fermentation of carbohydrates in the colon produces gases (H 2 , CO 2 , and methane), resulting in excessive flatus, bloating and distention, and abdominal pain.
Enzyme deficiencies can be congenital, acquired (primary), or secondary. Congenital deficiencies (eg, of lactase or sucrase-isomaltase) are rare.
Acquired lactase deficiency (primary adult hypolactasia) is the most common form of carbohydrate intolerance. Lactase levels are high in neonates, permitting digestion of milk; in most ethnic groups (80% of blacks and Hispanics, > 90% of Asians), the levels decrease in the post-weaning period rendering older children and adults unable to digest significant amounts of lactose. However, 80 to 85% of whites of Northwest European descent produce lactase throughout life and are thus able to digest milk and milk products. It is unclear why the normal state of > 75% of the world’s population should be labeled a “deficiency.”
Secondary lactase deficiency occurs in conditions that damage the small-bowel mucosa (eg, celiac disease—see Celiac Disease, tropical sprue—see Tropical Sprue, acute intestinal infections—see GI Infection and Infestation). In infants, temporary secondary disaccharidase deficiency may complicate enteric infections or abdominal surgery. Recovery from the underlying disease is followed by an increase in activity of the enzyme.
Symptoms and signs are similar in all disaccharidase deficiencies. A child who cannot tolerate lactose develops diarrhea after ingesting significant amounts of milk and may not gain weight. An affected adult may have watery diarrhea, bloating, excessive flatus, nausea, borborygmi, and abdominal cramps after ingesting lactose. The patient often recognizes early in life that dairy causes GI problems and avoids eating dairy products. Symptoms typically require ingestion of more than the equivalent of 250 to 375 mL (8 to 12 oz) of milk. Diarrhea may be severe enough to purge other nutrients before they can be absorbed. Symptoms may be similar to and can be confused with irritable bowel syndrome (see Irritable Bowel Syndrome (IBS)).
Lactose intolerance can usually be diagnosed with a careful history supported by dietary challenge. Patients usually have a history of diarrhea and/or gas after ingestion of milk and dairy foods; other symptoms, such as rash, wheezing, or other anaphylactic symptoms (particularly in infants and children), suggest a cow's milk allergy. Milk allergy is rare in adults and also may cause vomiting and symptoms of esophageal reflux, which are not manifestations of carbohydrate intolerance. The diagnosis is also suggested if the stool from chronic or intermittent diarrhea is acidic (pH < 6) and can be confirmed by an H 2 breath test or a lactose tolerance test.
In the H 2 breath test, 50 g of lactose is given orally and the H 2 produced by bacterial metabolism of undigested lactose is measured with a breath meter at 2, 3, and 4 h postingestion. Most affected patients have an increase in expired H 2 of > 20 ppm over baseline. Sensitivity and specificity are > 95%.
The lactose tolerance test is less sensitive, about 75%, although specificity is > 95%. Oral lactose (1.0 to 1.5 g/kg body weight) is given. Serum glucose is measured before ingestion and 60 and 120 min after. Lactose-intolerant patients develop diarrhea, abdominal bloating, and discomfort within 20 to 30 min, and their serum glucose levels do not rise to > 20 mg/dL (< 1.1 mmol/L) above baseline.
Carbohydrate malabsorption is readily controlled by avoiding dietary sugars that cannot be absorbed (ie, following a lactose-free diet in cases of lactase deficiency). However, because the degree of lactose malabsorption varies greatly, many patients can ingest up to 375 mL (18 g of lactose) of milk daily without symptoms. Yogurt is usually tolerated because it contains an appreciable amount of lactase produced by intrinsic Lactobacilli. Cheese contains lower amounts of lactose than milk and is often tolerated, depending on the amount ingested.
For symptomatic patients wishing to drink milk, lactose in milk can be predigested by the addition of a commercially prepared lactase, and pretreated milk is now available. Enzyme supplements should be an adjunct to, not a substitute for, dietary restriction. Lactose-intolerant patients must take Ca supplements (1200 to 1500 mg/day).
Disaccharide deficiency (usually of lactase) can be acquired or, rarely, congenital.
Undigested disaccharides, such as lactose, create an osmotic load that causes diarrhea.
Intestinal bacteria metabolize some undigested disaccharides, producing gases that cause distention and flatus.
Confirm clinical diagnosis by doing an H 2 breath test.
Dietary restriction is usually adequate treatment.
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