Find information on medical topics, symptoms, drugs, procedures, news and more, written for the health care professional.

Oxyhemoglobin dissociation curve.

Oxyhemoglobin dissociation curve.
Oxyhemoglobin dissociation curve.

Arterial oxyhemoglobin saturation is related to P o 2 . P o 2 at 50% saturation (P 50 ) is normally 27 mm Hg. The dissociation curve is shifted to the right by increased hydrogen ion (H + ) concentration, increased RBC 2,3-diphosphoglycerate (DPG), increased temperature (T), and increased P co 2 . Decreased levels of H + , DPG, temperature, and P co 2 shift the curve to the left. Hb characterized by a rightward shifting of the curve has a decreased affinity for oxygen, and Hb characterized by a leftward shifting of the curve has an increased affinity for oxygen.