Overview of Seronegative Spondyloarthropathies
Seronegative spondyloarthropathies (seronegative spondyloarthritides) share certain clinical characteristics (eg, back pain, uveitis, GI symptoms, rashes). Some are strongly associated with the HLA-B27 allele. Clinical and genetic similarities suggest that they also share similar causes or pathophysiologies. Rheumatoid factor (RF) is usually negative in the spondyloarthropathies (hence, why they are called seronegative spondyloarthropathies). They include ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and other disorders.
Juvenile-onset spondyloarthropathy is an asymmetric, mostly lower extremity spondyloarthropathy that begins most commonly in boys aged 7 to 16.
Spondyloarthropathy can also develop in people without characteristics of other specific spondyloarthropathy (undifferentiated spondyloarthropathy). Treatment of the arthritis of these other spondyloarthropathies is similar to the treatment of reactive arthritis.