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Other Neurologic Imaging Studies

By Michael C. Levin, MD, Saskatchewan Multiple Sclerosis Clinical Research Chair and Professor of Neurology and Anatomy-Cell Biology; Adjunct Professor of Neurology, College of Medicine, University of Saskatchewan; University of Tennessee Health Science Center

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Cerebral catheter angiography

X-rays taken after a radiopaque agent is injected via an intra-arterial catheter show individual cerebral arteries and venous structures of the brain. With digital data processing (digital subtraction angiography), small amounts of agent can produce high-resolution images.

Cerebral angiography supplements CT and MRI in delineating the site and vascularity of intracranial lesions; it has been the gold standard for diagnosing stenotic or occluded arteries, congenitally absent vessels, aneurysms, and arteriovenous malformations. Vessels, as small as 0.1 mm, can be visualized. However, its use has decreased dramatically with the advent of MRA and CT angiography. It is still routinely used when cerebral vasculitis is suspected and when angiographic interventions (eg, angioplasty, stent placement, intra-arterial thrombolysis, aneurysm obliteration) may be necessary.

Duplex Doppler ultrasonography

This noninvasive procedure can assess dissection, stenosis, occlusion, and ulceration of the carotid bifurcation. It is safe and rapid, but it does not provide the detail of angiography. It is preferable to periorbital Doppler ultrasonography and oculoplethysmography for evaluating patients with carotid artery transient ischemic attacks and is useful for following an abnormality over time.

Transcranial Doppler ultrasonography helps evaluate residual blood flow after brain death, vasospasm of the middle cerebral artery after subarachnoid hemorrhage, and vertebrobasilar stroke.


Ultrasonography can be used at the bedside (usually in the neonatal ICU) to detect hemorrhage and hydrocephalus in children < 2 yr.

CT has replaced echoencephalography in older children and adults.


X-rays are taken after a radiopaque agent is injected into the subarachnoid space via lumbar puncture. MRI has replaced myelography for evaluation of intraspinal abnormalities, but CT myelography is still done when MRI is unavailable.

Contraindications are the same as those for lumbar puncture.

Myelography may exacerbate the effects of spinal cord compression, especially if too much fluid is removed too rapidly. Rarely, myelography results in inflammation of the arachnoid membranes around the spinal nerves (arachnoiditis), which may cause chronic pain and paresthesias in the lower back and extremities.