* This is the Professional Version. *
- Risk Factors
- Symptoms and Signs
- Resources In This Article
- Drugs Mentioned In This Article
Overview of Undernutrition
Undernutrition is a form of malnutrition. (Malnutrition also includes overnutrition—see Obesity and the Metabolic Syndrome). Undernutrition can result from inadequate ingestion of nutrients, malabsorption, impaired metabolism, loss of nutrients due to diarrhea, or increased nutritional requirements (as occurs in cancer or infection). Undernutrition progresses in stages; it may develop slowly when it is due to anorexia or very rapidly, as sometimes occurs when it is due to rapidly progressive cancer-related cachexia. First, nutrient levels in blood and tissues change, followed by intracellular changes in biochemical functions and structure. Ultimately, symptoms and signs appear. Diagnosis is by history, physical examination, body composition analysis (see page Obesity : Body composition analysis), and sometimes laboratory tests (eg, albumin).
Undernutrition is associated with many disorders and circumstances, including poverty and social deprivation. Risk is also greater at certain times (ie, during infancy, early childhood, adolescence, pregnancy, breastfeeding, and old age).
Infants and children are particularly susceptible to undernutrition because of their high demand for energy and essential nutrients. Because vitamin K does not readily cross the placenta, neonates may be deficient, so all are given a single injection of vitamin K within 1 h of birth to prevent hemorrhagic disease of the newborn, a life-threatening disorder (see page Etiology). Infants fed only breast milk, which is typically low in vitamin D, are given supplemental vitamin D; they can develop vitamin B12 deficiency if the mother is a vegan. Inadequately fed infants and children are at risk of protein-energy undernutrition (PEU—previously called protein-energy malnutrition) and deficiencies of iron, folate (folic acid), vitamins A and C, copper, and zinc.
During adolescence, nutritional requirements increase because the growth rate accelerates. Anorexia nervosa (see Anorexia Nervosa) may affect adolescent girls in particular.
Requirements for nutrients increase during pregnancy and breastfeeding. Aberrations of diet, including pica (consumption of nonnutritive substances, such as clay and charcoal), may occur during pregnancy. Anemia due to iron deficiency is common, as is anemia due to folate deficiency, especially among women who have taken oral contraceptives. Vitamin D deficiency is common during late pregnancy, predisposing the child to decreased bone mass.
Aging—even when disease or dietary deficiency is absent—leads to sarcopenia (progressive loss of lean body mass), starting after age 40 and eventually amounting to a muscle loss of about 10 kg (22 lb) in men and 5 kg (11 lb) in women. Undernutrition contributes to sarcopenia, and sarcopenia accounts for many of the complications of undernutrition (eg, decreased nitrogen balance, increased susceptibility to infections). Causes of sarcopenia include the following:
Aging decreases basal metabolic rate (due mainly to decreased fat-free mass), total body weight, height, and skeletal mass; from about age 40 to age 65, mean body fat (as a percentage of body weight) increases to about 30% (from 20%) in men and to 40% (from 27%) in women.
From age 20 to 80, food intake decreases, especially in men. Anorexia due to aging itself has many causes, including reduced adaptive relaxation of the stomach’s fundus, increased release and activity of cholecystokinin (which produces satiation), and increased leptin (an anorectic hormone produced by fat cells). Diminished taste and smell can decrease eating pleasure but usually decrease food intake only slightly. Anorexia may have other causes (eg, loneliness, inability to shop or prepare meals, dementia, some chronic disorders, use of certain drugs). Depression is a common cause. Occasionally, anorexia nervosa (sometimes called anorexia tardive in the elderly), paranoia, or mania interferes with eating. Dental problems limit the ability to chew and subsequently to digest foods. Swallowing difficulties (eg, due to strokes, other neurologic disorders, esophageal candidiasis, or xerostomia) are common. Poverty or functional impairment limits access to nutrients.
The institutionalized elderly are at particular risk of PEU. They are often confused and may be unable to express hunger or preferences for foods. They may be physically unable to feed themselves. Chewing or swallowing may be very slow, making it tedious for another person to feed them enough food.
In the elderly, particularly the institutionalized elderly, inadequate intake and often decreased absorption or synthesis of vitamin D, increased demand for vitamin D, and inadequate exposure to sunshine contribute to vitamin D deficiency and osteomalacia (see page Vitamin D Deficiency and Dependency).
Diabetes, some chronic disorders that affect the GI tract, intestinal resection, and certain other GI surgical procedures tend to impair absorption of fat-soluble vitamins, vitamin B12, Ca, and iron. Gluten enteropathy, pancreatic insufficiency, or other disorders can result in malabsorption. Decreased absorption possibly contributes to iron deficiency and osteoporosis. Liver disorders impair storage of vitamins A and B12 and interfere with metabolism of protein and energy sources. Renal insufficiency predisposes to protein, iron, and vitamin D deficiencies. Anorexia causes some patients with cancer or depression and many with AIDS to consume inadequate amounts of food. Infections, trauma, hyperthyroidism, extensive burns, and prolonged fever increase metabolic demands. Any condition that increases cytokines may be accompanied by muscle loss, lipolysis, low albumin levels, and anorexia.
Iron deficiency can occur in ovo-lacto vegetarians (although such a diet can be compatible with good health). Vegans may develop vitamin B12 deficiency unless they consume yeast extracts or Asian-style fermented foods. Their intake of Ca, iron, and zinc also tends to be low.
A fruit-only diet is not recommended because it is deficient in protein, Na, and many micronutrients.
Patients with alcohol or drug dependency may neglect their nutritional needs. Absorption and metabolism of nutrients may also be impaired. IV drug addicts typically become undernourished, as do alcoholics who consume ≥ 1 quart of hard liquor/day. Alcoholism can cause deficiencies of Mg, zinc, and certain vitamins, including thiamin.
Symptoms vary depending on the cause and type of undernutrition (see page Protein-Energy Undernutrition : Symptoms and Signs and Vitamin Deficiency, Dependency, and Toxicity).
Diagnosis is based on results of medical and diet histories, physical examination, body composition analysis (see page Obesity : Body composition analysis), and selected laboratory tests.
History should include questions about dietary intake (see Figure: Mini nutritional assessment.), recent changes in weight, and risk factors for undernutrition, including drug and alcohol use. Unintentional loss of ≥ 10% of usual body weight during a 3-mo period indicates a high probability of undernutrition. Social history should include questions about whether money is available for food and whether the patient can shop and cook.
Review of systems should focus on symptoms of nutritional deficiencies (see Table: Symptoms and Signs of Nutritional Deficiency). For example, impaired night vision may indicate vitamin A deficiency.
Symptoms and Signs of Nutritional Deficiency
Mini nutritional assessment.
Physical examination should include measurement of height and weight, inspection of body fat distribution, and anthropometric measurements of lean body mass. Body mass index (BMI = weight[kg]/height[m]2) adjusts weight for height (see Table: Body Mass Index (BMI)). If weight is < 80% of what is predicted for the patient’s height or if BMI is ≤ 18, undernutrition should be suspected. Although these findings are useful in diagnosing undernutrition and are acceptably sensitive, they lack specificity.
The mid upper arm muscle area estimates lean body mass. This area is derived from the triceps skinfold thickness (TSF) and mid upper arm circumference. Both are measured at the same site, with the patient’s right arm in a relaxed position. The average mid upper arm circumference is about 32 ± 5 cm for men and 28 ± 6 cm for women. The formula for calculating the mid upper arm muscle area in cm2 is as follows:
This formula corrects the upper arm area for fat and bone. Average values for the mid upper arm muscle area are 54 ± 11 cm2 for men and 30 ± 7 cm2 for women. A value < 75% of this standard (depending on age) indicates depletion of lean body mass (see Table: Mid Upper Arm Muscle Area in Adults). This measurement may be affected by physical activity, genetic factors, and age-related muscle loss.
Mid Upper Arm Muscle Area in Adults
Physical examination should focus on signs of specific nutritional deficiencies. Signs of PEU (eg, edema, muscle wasting, skin changes) should be sought. Examination should also focus on signs of conditions that could predispose to nutritional deficiencies, such as dental problems. Mental status should be assessed, because depression and cognitive impairment can lead to weight loss.
The widely used Subjective Global Assessment (SGA) uses information from the patient history (eg, weight loss, change in intake, GI symptoms), physical examination findings (eg, loss of muscle and subcutaneous fat, edema, ascites), and the clinician’s judgment of the patient’s nutritional status. The Mini Nutritional Assessment (MNA) has been validated and is widely used, especially for elderly patients (see Figure: Mini nutritional assessment.). The Simplified Nutrition Assessment Questionnaire (SNAQ), a simple, validated method of predicting future weight loss, may be used (see Figure: Simplified nutrition assessment questionnaire (SNAQ).).
The extent of laboratory testing needed is unclear and may depend on the patient’s circumstances. If the cause is obvious and correctable (eg, a wilderness survival situation), testing is probably of little benefit. Other patients may require more detailed evaluation.
Serum albumin measurement is the laboratory test most often used. Decreases in albumin and other proteins (eg, prealbumin [transthyretin], transferrin, retinol-binding protein) may indicate protein deficiency or PEU. As undernutrition progresses, albumin decreases slowly; prealbumin, transferrin, and retinol-binding protein decrease rapidly. Albumin measurement is inexpensive and predicts morbidity and mortality better than measurement of the other proteins. However, the correlation of albumin with morbidity and mortality may be related to nonnutritional as well as nutritional factors. Inflammation produces cytokines that cause albumin and other nutritional protein markers to extravasate, decreasing serum levels. Because prealbumin, transferrin, and retinol-binding protein decrease more rapidly during starvation than does albumin, their measurements are sometimes used to diagnose or assess the severity of acute starvation. However, whether they are more sensitive or specific than albumin is unclear.
Total lymphocyte count, which often decreases as undernutrition progresses, may be determined. Undernutrition causes a marked decline in CD4+ T lymphocytes, so this count may not be useful in patients who have AIDS.
Skin tests using antigens can detect impaired cell-mediated immunity in PEU and in some other disorders of undernutrition (see page Approach to the Patient With Suspected Immunodeficiency : Evaluation).
Other laboratory tests, such as measuring vitamin and mineral levels, are used selectively to diagnose specific deficiencies.
Drug NameSelect Trade
* This is the Professional Version. *