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Acute Pericarditis


Brian D. Hoit

, MD, Case Western Reserve University School of Medicine

Reviewed/Revised Jul 2022 | Modified Sep 2022
Topic Resources

Acute pericarditis is inflammation of the pericardium (the flexible two-layered sac that envelops the heart) that begins suddenly, is often painful, and causes fluid and blood components such as fibrin, red blood cells, and white blood cells to enter the pericardial space.

  • Certain infections and other conditions that inflame the pericardium cause pericarditis.

  • Fever and chest pain, which is sharp and varies with position and movement and occasionally may feel like a heart attack, are common symptoms.

  • Doctors base the diagnosis on symptoms and occasionally by hearing a tell-tale sound when listening to the heartbeat with a stethoscope.

  • People are often hospitalized and given drugs to reduce pain and inflammation.

Sometimes the inflammation can cause excess fluid to enter the pericardial space (pericardial effusion). Sometimes, when pericarditis is due to an injury, cancer, or heart surgery, the fluid is blood.

Causes of Acute Pericarditis

Causes of acute pericarditis include

After a heart attack, acute pericarditis develops during the first day or two in 10 to 15% of people and after about 10 days to 2 months in 1 to 3% (subacute pericarditis). Subacute pericarditis is caused by the same disorders that cause acute pericarditis.

Symptoms of Acute Pericarditis

Usually acute pericarditis causes sharp chest pain, which often extends to the left shoulder and sometimes down the left arm. The pain may be similar to that of a heart attack, except that it tends to be made worse by lying down, swallowing food, coughing, or even deep breathing. The accumulating fluid or blood in the pericardial space puts pressure on the heart, interfering with its ability to pump blood. If the pressure is too high, cardiac tamponade Cardiac Tamponade Cardiac tamponade is pressure on the heart by blood or fluid that accumulates in the two-layered sac around the heart (pericardium). This disorder interferes with the heart's ability to pump... read more —a potentially fatal condition—may occur. Sometimes acute pericarditis does not cause any symptoms.

Pericarditis due to tuberculosis begins insidiously, sometimes without obvious symptoms of infection. It may cause fever and symptoms of heart failure, such as weakness, fatigue, and difficulty breathing. Cardiac tamponade may occur.

Acute pericarditis due to a viral infection is usually painful but short-lived and has no lasting effects.

Pericarditis that develops about 10 days to 2 months after a heart attack is usually accompanied by postmyocardial infarction syndrome Pericarditis The heart muscle needs a constant supply of oxygen-rich blood. The coronary arteries, which branch off the aorta just after it leaves the heart, deliver this blood. An acute coronary syndrome... read more (Dressler syndrome), which includes fever, pericardial effusion (extra fluid in the pericardial space), pleuritic pain (pain due to inflammation of the pleura, which are the membranes covering the lungs), pleural effusion (fluid between the two layers of the pleura), and joint pain.

Symptoms of acute pericarditis often go away on their own but come back in up to 30% of people.

In 15 to 25 percent of people with idiopathic pericarditis, symptoms recur on and off for months or years (called recurrent pericarditis).

Diagnosis of Acute Pericarditis

  • Electrocardiography

  • Chest x-ray

  • Echocardiography

  • Tests to identify the cause

Doctors can usually diagnose acute pericarditis based on the person's description of the pain and the sounds heard by listening through a stethoscope placed on the person's chest. Pericarditis can cause a crunching sound similar to the creaking of a leather shoe or a scratchy sound similar to the rustling of dry leaves (pericardial rub). Doctors can often diagnose pericarditis a few hours to a few days after a heart attack based on hearing these sounds.

Tests for the cause of pericarditis

Sometimes the cause of pericarditis is obvious, such as a recent heart attack. Other times the cause may not be clear.

Echocardiography may suggest the cause—for example, the image shown on the echocardiogram or chest x-ray may suggest cancer.

If the cause of pericarditis remains unknown, doctors may withdraw a sample of the pericardial fluid and/or pericardial tissue using a needle inserted through the chest wall (pericardiocentesis). The fluid and tissue are sent to the laboratory for testing.

Prognosis of Acute Pericarditis

The prognosis for people who have pericarditis depends on the cause. When pericarditis is caused by a virus or when the cause is not apparent, recovery usually takes 1 to 3 weeks. Complications or recurrences can slow recovery. People with cancer that has invaded the pericardium rarely survive beyond 12 to 18 months.

Treatment of Acute Pericarditis

  • Anti-inflammatory drugs, such as nonsteroidal anti-inflammatory drugs or colchicine

  • Treatment of the underlying disorder, such as cancer

  • Infrequently, surgical treatment such as pericardiotomy

Regardless of the cause, doctors sometimes hospitalize people with pericarditis, particularly people with high-risk features (fever, subacute onset, use of immunosuppressive drugs, recent trauma, oral anticoagulant therapy, failure to improve with use of aspirin or nonsteroidal anti-inflammatory drugs Nonsteroidal Anti-Inflammatory Drugs Pain relievers (analgesics) are the main drugs used to treat pain. Doctors choose a pain reliever based on the type and duration of pain and on the drug's likely benefits and risks. Most pain... read more [NSAIDs], myopericarditis [pericarditis involving the heart muscle as well as the pericardium] and moderate or large pericardial effusions). The person is monitored for complications, particularly cardiac tamponade.

Anti-inflammatory drugs

Acute pericarditis usually responds to colchicine or NSAIDs (such as aspirin and ibuprofen) taken by mouth. Once pain and signs of inflammation have been relieved, the drugs are gradually reduced. Colchicine also decreases the chance of pericarditis returning later. Intense pain may require an opioid, such as morphine. Prednisone, a corticosteroid, does not directly reduce pain but relieves it by reducing inflammation. However, prednisone is not used for everyone because it can make a viral infection (which people may also have) more severe. Prednisone also increases the chance that pericarditis will return later.

Treating the underlying disorder

Further treatment of acute pericarditis varies, depending on the cause. For people who have kidney failure, increasing the frequency of dialysis usually results in improvement.

Drugs that may cause pericarditis are stopped whenever possible.

People who have cancer may respond to chemotherapy or radiation therapy.

If pericarditis that is caused by a virus, an injury, or an unidentified disorder recurs, aspirin or ibuprofen, sometimes along with colchicine, may provide relief. If these drugs do not help, doctors may give corticosteroids (as long as the cause was not an infection). The corticosteroids are sometimes injected into the pericardial space. If drug treatment is ineffective, doctors may remove the pericardium surgically.

If a bacterial infection is the cause, treatment consists of antibiotics and surgical drainage of pus from the pericardium.

Surgical treatment

Fluid may be drained from the pericardium by inserting a thin catheter into the pericardial space (pericardiocentesis).

Sometimes a balloon-tipped catheter is inserted through the skin. The balloon is then inflated to create a hole (window) in the pericardium. This procedure, called percutaneous balloon pericardiotomy, is usually done as an alternative to surgery when effusions are due to cancer or recur.

Alternatively, a small incision is made below the breast bone, and a piece of the pericardium is removed. Then a tube is inserted into the pericardial space. This procedure, called a subxiphoid pericardiotomy, is often done when effusions are due to bacterial infections. Both procedures require a local anesthetic, can be done at the person's bedside, allow fluid to drain continuously, and are effective.

Drugs Mentioned In This Article

Generic Name Select Brand Names
Coumadin, Jantoven
Hepflush-10 , Hep-Lock, Hep-Lock U/P, Monoject Prefill Advanced Heparin Lock Flush, SASH Normal Saline and Heparin
Procanbid, Pronestyl, Pronestyl-SR
Dilantin, Dilantin Infatabs, Dilantin-125, Phenytek
Aluvea , BP-50% Urea , BP-K50, Carmol, CEM-Urea, Cerovel, DermacinRx Urea, Epimide-50, Gord Urea, Gordons Urea, Hydro 35 , Hydro 40, Kerafoam, Kerafoam 42, Keralac, Keralac Nailstik, Keratol, Keratol Plus, Kerol, Kerol AD, Kerol ZX, Latrix, Mectalyte, Nutraplus, RE Urea 40, RE Urea 50 , Rea Lo, Remeven, RE-U40, RYNODERM , U40, U-Kera, Ultra Mide 25, Ultralytic-2, Umecta, Umecta Nail Film, URALISS, Uramaxin , Uramaxin GT, Urea, Ureacin-10, Ureacin-20, Urealac , Ureaphil, Uredeb, URE-K , Uremez-40, Ure-Na, Uresol, Utopic, Vanamide, Xurea, X-VIATE
Anacin Adult Low Strength, Aspergum, Aspir-Low, Aspirtab , Aspir-Trin , Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength, Bayer Aspirin Plus, Bayer Aspirin Regimen, Bayer Children's Aspirin, Bayer Extra Strength, Bayer Extra Strength Plus, Bayer Genuine Aspirin, Bayer Low Dose Aspirin Regimen, Bayer Womens Aspirin , BeneHealth Aspirin, Bufferin, Bufferin Extra Strength, Bufferin Low Dose, DURLAZA, Easprin , Ecotrin, Ecotrin Low Strength, Genacote, Halfprin, MiniPrin, St. Joseph Adult Low Strength, St. Joseph Aspirin, VAZALORE, Zero Order Release Aspirin, ZORprin
Advil, Advil Children's, Advil Children's Fever, Advil Infants', Advil Junior Strength, Advil Migraine, Caldolor, Children's Ibuprofen, ElixSure IB, Genpril , Ibren , IBU, Midol, Midol Cramps and Body Aches, Motrin, Motrin Children's, Motrin IB, Motrin Infants', Motrin Junior Strength, Motrin Migraine Pain, PediaCare Children's Pain Reliever/Fever Reducer IB, PediaCare Infants' Pain Reliever/Fever Reducer IB, Samson-8
ARYMO ER, Astramorph PF, Avinza, DepoDur, Duramorph PF, Infumorph, Kadian, MITIGO, MORPHABOND, MS Contin, MSIR, Opium Tincture, Oramorph SR, RMS, Roxanol, Roxanol-T
Deltasone, Predone, RAYOS, Sterapred, Sterapred DS
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