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Year-Round Allergies

(Perennial Allergies)


James Fernandez

, MD, PhD, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University

Reviewed/Revised Oct 2022

Year-round (perennial) allergies result from indoor exposure to airborne substances (such as house dust) that are present throughout the year.

  • The nose is congested, itchy, and sometimes runny, and the mouth and throat are itchy.

  • The symptoms and activities that trigger the allergy usually suggest the diagnosis.

  • Avoiding the allergen is best, but drugs, such as antihistamines, can help relieve symptoms.

Perennial allergies may occur at any time of year—unrelated to the season—or may last year-round. Perennial allergies are often a reaction to house dust. House dust may contain mold and fungal spores, fibers of fabric, animal dander, dust mite droppings, and bits of insects. Substances in and on cockroaches are often the cause of allergic symptoms. These substances are present in houses year-round but may cause more severe symptoms during the cold months when more time is spent indoors. (Substances that trigger an allergic reaction are called allergens.)

Perennial rhinitis is often caused by something other than an allergy, such as aspirin or another nonsteroidal anti-inflammatory drug (NSAID) or another form of rhinitis Rhinitis Rhinitis is inflammation and swelling of the mucous membrane of the nose, characterized by a runny nose and stuffiness and usually caused by the common cold or a seasonal allergy. Colds and... read more Rhinitis .

Did You Know...

  • Cockroaches and dust mites are often to blame for year-round allergies.

Symptoms of Year-Round Allergies

The most obvious symptom of perennial allergies is a chronically stuffy nose. The nose runs, producing a clear watery discharge. The nose, roof of the mouth, and back of the throat may itch. Itching may start gradually or abruptly. Sneezing is common.

When affected, the eyes water and itch. The whites of the eyes may become red, and the eyelids may become red and swollen. The skin under the eyes can become dark (allergic shiner).

Diagnosis of Year-Round Allergies

  • A doctor's evaluation

Diagnosis of perennial allergies is based on symptoms plus the circumstances in which they occur—that is, in response to certain activities, such as petting a cat. It can often be diagnosed based on this information alone.

Allergy testing

Tests are needed only if people do not respond to treatment.

In such cases, skin prick tests Skin testing Allergic reactions (hypersensitivity reactions) are inappropriate responses of the immune system to a normally harmless substance. Usually, allergies cause sneezing, watery and itchy eyes, a... read more Skin testing can help confirm the diagnosis and identify the trigger for symptoms (such as dust mites or cockroaches). For these tests, a drop of each extract is placed on the person’s skin, which is then pricked with a needle through the drop. Doctors then watch to see if there is a wheal and flare reaction (a pale, slightly elevated swelling surrounded by a red area).

Prevention of Year-Round Allergies

Avoiding or removing the allergen, if possible, is recommended, thus preventing the development of symptoms and the need to take medication.

If people are allergic to house dust, animal dander, or other indoor allergens, some changes in the environment may prevent or lessen symptoms:

  • Removing items that collect dust, such as knickknacks, magazines, and books

  • Removing soft toys

  • Replacing upholstered furniture and carpets or vacuuming them frequently

  • Replacing draperies and shades with blinds

  • Frequently washing bed sheets, pillowcases, and blankets in hot water

  • Treating homes with heat-steam

  • Covering mattresses and pillows with finely woven fabrics that cannot be penetrated by dust mites and allergen particles

  • Using synthetic-fiber pillows

  • Frequently cleaning the house, including dusting, vacuuming, and wet-mopping

  • Using air conditioners and dehumidifiers to reduce the high indoor humidity that encourages the breeding of dust mites

  • Using high-efficiency particulate air (HEPA) vacuums and filters

  • Limiting pets to certain rooms or keeping them out of the house and washing the pet frequently

  • Exterminating cockroaches

Treatment of Year-Round Allergies

  • Corticosteroid nasal sprays

  • Antihistamines

  • Decongestants

  • Sometimes allergen immunotherapy

  • For nasal polyps, sometimes surgery

Avoiding the allergen is the best way to treat as well as prevent allergies.

Drug treatment of perennial allergies is similar to that for seasonal allergies. It includes corticosteroid nasal sprays, antihistamines, and decongestants.

A corticosteroid nasal spray is usually very effective and is used first. Most of these sprays have few side effects, although they can cause nosebleeds and a sore nose.

An antihistamine, taken by mouth or used as a nasal spray, can be used instead of or in addition to a corticosteroid nasal spray. Antihistamines are often used with a decongestant, such as pseudoephedrine, taken by mouth.

Many antihistamine-decongestant combinations are available over the counter as a single tablet. However, people with high blood pressure should not take a decongestant unless a doctor recommends it and monitors its use. Also, people who take a monoamine oxidase inhibitor (a type of antidepressant) cannot take a product that combines an antihistamine and a decongestant. Antihistamine-decongestant combination drugs should not be given to young children.

Antihistamines may have side effects, particularly anticholinergic effects Anticholinergic: What Does It Mean? Anticholinergic: What Does It Mean? . Anticholinergic effects include sleepiness, dry mouth, blurred vision, constipation, difficulty with urination, confusion, and light-headedness.

Decongestants are also available over the counter as nose drops or sprays. They should not be used for more than a few days at a time because using them continually for a week or more may worsen or prolong nasal congestion—called a rebound effect—and may eventually result in chronic congestion.

Side effects tend to be fewer and less severe with nasal sprays than with drugs taken by mouth.

Other drugs are sometimes useful. Cromolyn (a mast cell stabilizer Mast cell stabilizers Allergic reactions (hypersensitivity reactions) are inappropriate responses of the immune system to a normally harmless substance. Usually, allergies cause sneezing, watery and itchy eyes, a... read more Mast cell stabilizers ) is available by prescription as a nasal spray and may help relieve a runny nose. To be effective, it must be used regularly.

Azelastine (which is an antihistamine and a mast cell stabilizer) and ipratropium (a drug that inhibits acetylcholine), both available by prescription as nasal sprays, may be effective. But these drugs can have anticholinergic effects similar to those of antihistamines taken by mouth, especially drowsiness.

Montelukast, a leukotriene inhibitor available by prescription, reduces inflammation and helps relieve a runny nose. It is best used only when other drugs are ineffective. Possible side effects include confusion, anxiety, depression, and abnormal muscle movements.

Regularly flushing out the sinuses with a warm water and salt (saline) solution may help loosen and wash out mucus and hydrate the nasal lining. This technique is called sinus irrigation.

When these treatments are ineffective, a corticosteroid Corticosteroids: Uses and Side Effects Corticosteroids: Uses and Side Effects may be taken by mouth or by injection for a short time (usually for fewer than 10 days). If taken by mouth or injection for a long time, corticosteroids can have serious side effects.

Allergen immunotherapy (desensitization)

Desensitization is a process that tries to teach the person's immune system not to react to an allergen. The person is given progressively larger doses of the allergen. The first dose is so small that even an allergic person will not react to it. However, the small dose starts to get the person's immune system used to the allergen. Then the dose is gradually increased. Each increase is so small that the immune system still does not react. The dose is increased until the person is not reacting to the same amount of allergen that once caused symptoms.

Immunotherapy is needed in the following situations:

Immunotherapy for year-round allergies consists of giving gradually increasing doses of allergen placed under the tongue (sublingual) or injected into the skin. Because desensitization occasionally causes dangerous allergic reactions, people remain in the doctor’s office for at least 30 minutes afterward. If they do not have a reaction after first dose, they can take subsequent doses at home.

Allergen immunotherapy for hay fever should be started after the pollen season to prepare for the next season. Immunotherapy has more side effects when started during pollen season because the pollen allergens have already stimulated the immune system. Immunotherapy is most effective when continued year-round.


Drugs Mentioned In This Article

Generic Name Select Brand Names
Anacin Adult Low Strength, Aspergum, Aspir-Low, Aspirtab , Aspir-Trin , Bayer Advanced Aspirin, Bayer Aspirin, Bayer Aspirin Extra Strength, Bayer Aspirin Plus, Bayer Aspirin Regimen, Bayer Children's Aspirin, Bayer Extra Strength, Bayer Extra Strength Plus, Bayer Genuine Aspirin, Bayer Low Dose Aspirin Regimen, Bayer Womens Aspirin , BeneHealth Aspirin, Bufferin, Bufferin Extra Strength, Bufferin Low Dose, DURLAZA, Easprin , Ecotrin, Ecotrin Low Strength, Genacote, Halfprin, MiniPrin, St. Joseph Adult Low Strength, St. Joseph Aspirin, VAZALORE, Zero Order Release Aspirin, ZORprin
Contac Cold 12 Hour, Dimetapp Decongestant, Drixoral, ElixSure Cold, ElixSure Congestion, Entex, Genaphed , KidKare , Myfedrine, NASAL Decongestant, Nasofed, Nexafed, PediaCare Infants' Decongestant, Pseudo-Time, Silfedrine, Sudafed, Sudafed 12 Hour, Sudafed 24 Hour, Sudafed Children's Nasal Decongestant, Sudafed Congestion, Sudafed Sinus Congestion, Sudogest, Sudogest 12 Hour, Sudogest Children's , Tylenol Children's Simply Stuffy, Zephrex-D
Astelin, Astepro, Children's ASTEPRO, Optivar
Atrovent, Atrovent HFA
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