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Salmonella Infections


Larry M. Bush

, MD, FACP, Charles E. Schmidt College of Medicine, Florida Atlantic University

Reviewed/Revised Apr 2022 | Modified Jul 2023
Topic Resources
  • People are usually infected when they eat contaminated food, such as undercooked chicken or eggs.

  • The bacteria usually infect the digestive tract but can travel through the bloodstream and infect other parts of the body.

  • People have nausea and crampy abdominal pain, followed by watery diarrhea, fever, and vomiting.

  • Identifying the bacteria in a sample, usually of stool, confirms the diagnosis.

  • Lost fluids are replaced.

  • Antibiotics are usually not helpful for people who have Salmonella intestinal infections, but antibiotics are helpful for people who are at risk of or have bacteremia.

There are over 2,500 different types of Salmonella bacteria.

Some Salmonella reside only in people. Other species of Salmonella normally reside in the digestive tract of many wild and domestic animals, such as cattle, sheep, pigs, fowl, and reptiles (including snakes, lizards, and turtles). Many of these can cause infections in people.

Salmonella bacteria are excreted in the feces of infected animals and people, leading to contamination. In the United States during the 1970s, many infections were spread by pet turtles, so their sale was prohibited, resulting in fewer infections. Recently, the legal and illegal sale of pet reptiles has increased. Up to 90% of pet reptiles and amphibians, such as aquatic frogs, are infected with Salmonella.

People are infected usually by eating undercooked poultry or eggs but sometimes by eating undercooked beef and pork, unpasteurized dairy products, or contaminated seafood or fresh produce. Salmonella bacteria can infect the ovaries of hens and thus infect the egg before the egg is laid. Other foods may be contaminated by animal feces (for example, in slaughterhouses) or by infected food handlers who do not adequately wash their hands after using a toilet. People can also become infected if they drink contaminated water. Other reported sources of infection include infected pet turtles and reptiles and contaminated marijuana.

Because stomach acid tends to destroy Salmonella, a large number of these bacteria must be consumed for infection to develop, unless people have a deficiency of stomach acid. Such a deficiency may occur in

  • Children under 1 year old

  • Older people

  • People taking antacids or drugs that inhibit stomach acid production, including histamine-2 (H2) blockers (such as famotidine) or proton pump inhibitors (such as omeprazole)

Did You Know...

  • In the United States, up to 90% of pet reptiles and amphibians are infected with Salmonella.

Spread through the bloodstream

Sometimes the bacteria enter the bloodstream (causing bacteremia Bacteremia Bacteremia is the presence of bacteria in the bloodstream. Bacteremia may result from ordinary activities (such as vigorous toothbrushing), dental or medical procedures, or from infections ... read more ) and spread, causing infections or collections of pus (abscesses) at distant sites, such as the bones, joints, urinary tract, and lungs. Bacteria may collect and cause infection on artificial (prosthetic) joints or heart valves, on a blood vessel graft, or on tumors. The lining of arteries, usually the aorta (the largest artery in the body), may be infected. Abscesses and infected arteries can cause chronic bacteremia.

The infection is more likely to spread through the bloodstream in the following people:

Symptoms of Salmonella Infections

When the intestine is infected, symptoms usually start 12 to 48 hours after the bacteria are ingested. Nausea and crampy abdominal pain occur, soon followed by watery diarrhea, fever, and vomiting. Salmonella symptoms resolve in 1 to 4 days. Occasionally, symptoms are more severe and last a long time.

Long after symptoms are gone, a few people continue to excrete the bacteria in their stool. Such people are called carriers.

About 10 to 30% of adults develop reactive arthritis Reactive Arthritis Reactive arthritis (previously called Reiter syndrome) is a spondyloarthritis causing inflammation of the joints and tendon attachments at the joints, often related to an infection. Joint pain... read more Reactive Arthritis weeks to months after diarrhea stops. This disorder causes pain and swelling, usually in the hips, knees, and Achilles tendon (which connects the heel bone and calf muscle).

Other symptoms may develop if bacteremia develops and infection spreads. For example, if a bone is infected, the area over it is often tender or painful. If a heart valve is infected, people may feel short of breath. If the aorta is infected, the back and abdomen may be painful.

People usually recover well. Exceptions are people who had a disorder, particularly one that weakens the immune system, before the Salmonella infection or who have a complication due to the infection.

Diagnosis of Salmonella Infections

  • Culture of stool, pus, blood, or a sample from the rectum

To diagnose a Salmonella infection, doctors take a sample of stool, pus, or blood or use a swab to obtain a sample from the rectum. The sample is sent to a laboratory where bacteria, if present, can be grown (cultured). Identifying the bacteria in the sample confirms the diagnosis.

Prevention of Salmonella Infections

Ways to prevent Salmonella infections include

  • Thoroughly cooking poultry, eggs, and ground beef

  • Not eating or drinking foods that contain raw eggs or raw (unpasteurized) milk, such as cookie dough, Hollandaise sauce, or certain homemade salad dressings

  • Thoroughly washing produce

  • Washing hands after going to the toilet or changing a diaper

  • Washing hands, kitchen work surfaces, and utensils with soap and water immediately after they have touched raw meat or poultry

  • Washing hands with soap after touching reptiles, birds, or baby chicks and after contact with feces of a pet

Special precautions are needed for people at high risk, such as young children. For example, because reptiles (such as turtles), chicks, and other young birds are particularly likely to have Salmonella, young children should not be allowed to handle these animals, and reptiles should not be in the same house as infants.

Infected people should not prepare food for others.

Treatment of Salmonella Infections

  • For intestinal infection, fluids

  • For people who are at risk of or have bacteremia, antibiotics

  • For abscesses, surgical drainage

Salmonella intestinal infection is treated with fluids given by mouth or, for severe infection, intravenously. Antibiotics do not shorten recovery time for people with Salmonella intestinal infection and may result in bacteria being excreted in the stool longer. Therefore, antibiotics are usually not given. However, people at risk of bacteremia (such as older residents of a nursing home, infants, and people with HIV infection) and people with implanted devices or materials (such as an artificial joint or heart valve or a blood vessel graft) are given antibiotics. They may be given ciprofloxacin, azithromycin, or ceftriaxone for several days. Children are given trimethoprim/sulfamethoxazole.

People with bacteremia are given antibiotics such as ciprofloxacin or ceftriaxone for about 2 weeks. If bacteremia persists, antibiotics are given for 4 to 6 weeks.

Abscesses are drained surgically, and antibiotics are given for at least 4 weeks.

If the aorta, a heart valve, or other areas (such as joints) are infected, surgery is usually required, and antibiotics are given for weeks or months.

More Information

The following English-language resource may be useful. Please note that THE MANUAL is not responsible for the content of this resource.

Centers for Disease Control and Prevention (CDC): Salmonella: A resource providing information about Salmonella, including outbreaks and prevention

Drugs Mentioned In This Article

Generic Name Select Brand Names
Heartburn Relief, Pepcid, Pepcid AC, Pepcid AC Maximum Strength, Zantac 360
Prilosec, Prilosec OTC
Cetraxal , Ciloxan, Cipro, Cipro XR, OTIPRIO, Proquin XR
Azasite, Zithromax, Zithromax Powder, Zithromax Single-Dose , Zithromax Tri-Pak, Zithromax Z-Pak, Zmax, Zmax Pediatric
Ceftrisol Plus, Rocephin
Primsol, Proloprim, TRIMPEX
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