Merck Manual

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Melvin I. Roat

, MD, FACS, Sidney Kimmel Medical College at Thomas Jefferson University

Last full review/revision May 2020
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Keratoconus is a bulging distortion of the cornea, leading to loss of visual acuity.

Keratoconus is a slowly progressive thinning and bulging of the cornea, usually bilateral, beginning between ages 10 and 25. Its cause is unknown.

Risk factors include the following:

The distorted cone shape of the cornea causes major changes in the refractive characteristics of the cornea (irregular astigmatism) that cannot be fully corrected with glasses. Progressing keratoconus necessitates frequent change of eyeglasses. Contact lenses may provide better vision correction and should be tried when eyeglasses are not satisfactory. Corneal transplant surgery Corneal Transplantation Corneal transplantations are done for several reasons: To reconstruct the cornea (eg, replacing a perforated cornea) To relieve intractable pain (eg, severe foreign body sensation due to recurrent... read more Corneal Transplantation may be necessary if visual acuity with contact lenses is inadequate, contact lenses are not tolerated, or a visually significant corneal scar (caused by tearing of stromal fibers) is present.

Newer treatments improve visual results by increasing tolerance of contact lenses and thus saving selected patients from transplantation. These include implantation of corneal ring segments, which push up the shoulders of the cone and thereby reduce the relative magnitude of the cone, and corneal collagen cross-linking, an ultraviolet light treatment that stiffens the cornea and thereby prevents further corneal thinning and bulging.

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