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Lower-Extremity Edema During Late Pregnancy

By

Emily E. Bunce

, MD, Wake Forest School of Medicine;


Robert P. Heine

, MD, Wake Forest School of Medicine

Reviewed/Revised Jul 2023
View PATIENT EDUCATION
Topic Resources

Edema is common during late pregnancy. It typically involves the lower extremities but occasionally appears as swelling or puffiness in the face or hands.

Etiology

The most common cause of edema in pregnancy is

  • Physiologic edema

Physiologic edema results from hormone-induced sodium retention. Edema may also occur when the enlarged uterus intermittently compresses the inferior vena cava during recumbency, obstructing outflow from both femoral veins.

Pathologic causes of edema are less common but often dangerous. They include

DVT is more common during pregnancy because pregnancy is a hypercoagulable state, and women may be less mobile.

Preeclampsia is a type of pregnancy-induced hypertension; however, not all women with preeclampsia develop upper extremity or facial edema.

Peripartum cardiomyopathy is a rare but serious condition. It can cause other nonspecific symptoms of pregnancy, including dyspnea and fatigue.

When extensive, cellulitis, which usually causes focal erythema, may resemble general edema.

Table

Evaluation

Evaluation of patients with lower-extremity edema during late pregnancy aims to exclude deep venous thrombosis (DVT), preeclampsia, peripartum cardiomyopathy, and other pathologic causes of edema. Physiologic edema is a diagnosis of exclusion.

History

History of present illness should include the estimated due date (and whether this is based on last menstrual period or ultrasonography), any risk factors for obstetric complications, and prior testing or complications during the current pregnancy. It should include symptom onset and duration, exacerbating and relieving factors (physiologic edema is reduced by lying in the left lateral decubitus position), and risk factors for DVT, preeclampsia, and peripartum cardiomyopathy.

High-risk factors for preeclampsia include

Moderate-risk factors for preeclampsia include

Risk factors for DVT include

Risk factors for peripartum cardiomyopathy include

Review of symptoms should seek symptoms of possible causes, including the following:

Physical examination

Examination begins with review of vital signs, particularly blood pressure.

Areas of edema are evaluated for distribution (ie, whether bilateral and symmetric or unilateral) and presence of redness, warmth, and tenderness.

General examination focuses on systems that may show findings of preeclampsia. Eye examination includes testing visual fields for deficits, and funduscopic examination should check for papilledema.

Cardiovascular examination includes auscultation of the heart and lungs for evidence of fluid overload (eg, audible S3 or S4 heart sounds, tachypnea, rales, crackles) and inspection of neck veins for jugular venous distention. The abdomen should be palpated for tenderness, especially in the epigastric or right upper quadrant region. Neurologic examination should assess mental status for confusion and seek focal neurologic deficits.

Red flags

The following findings are of particular concern:

  • Blood pressure 140/90 mm Hg

  • Unilateral leg or calf warmth, redness, or tenderness, with or without fever

  • Systemic symptoms or signs of preeclampsia, particularly mental status changes

  • Symptoms or signs of pulmonary edema

Interpretation of findings

Although edema is common during pregnancy, considering and ruling out the most dangerous causes (preeclampsia, peripartum cardiomyopathy, and DVT) are important:

  • If blood pressure is > 140/90 mm Hg, preeclampsia should be considered.

  • If edema involves only one leg, particularly when redness, warmth, and tenderness are present, DVT and cellulitis should be considered.

  • Bilateral leg edema suggests a physiologic process, preeclampsia, or peripartum cardiomyopathy as the cause.

  • Symptoms or signs of pulmonary edema, particularly in patients who have preeclampsia (or other risk factors), suggest peripartum cardiomyopathy.

Clinical findings help suggest a cause (see table ). Additional findings may suggest preeclampsia (see table ).

Table

Testing

If preeclampsia is suspected, urine protein is measured, and a complete blood count, electrolytes, blood urea nitrogen, glucose, creatinine, and liver tests are obtained; new-onset hypertension plus proteinuria indicates preeclampsia. Urine dipstick testing may be used. Many laboratories can more rapidly assess urine protein by measuring and calculating the urine protein:urine creatinine ratio. If the diagnosis is unclear, urine protein may be measured in a 24-hour collection. Proteinuria is no longer required to diagnose preeclampsia; abnormal laboratory or clinical findings of preeclampsia in patients with hypertension may also confirm preeclampsia.

If DVT is suspected, lower-extremity duplex ultrasonography is done.

If peripartum cardiomyopathy is suspected, ECG, chest X-ray, and echocardiography are done. BNP (brain [B-type] natriuretic peptide) or NT-proBNP (N-terminal pro b-type natriuretic peptide) is measured.

Treatment

Specific causes of edema during pregnancy are treated.

Physiologic edema can be reduced by the following:

  • Intermittently lying on the left side (left lateral decubitus position), which moves the uterus off the inferior vena cava

  • Intermittently elevating the lower extremities

  • Wearing elastic compression stockings

  • Wearing loose clothing that does not restrict blood flow, particularly in the legs

Key Points

  • Edema is common and usually benign (physiologic) during late pregnancy.

  • Physiologic edema is reduced by lying in the left lateral decubitus position, elevating the lower extremities, using compression stockings, and wearing loose clothing that does not restrict blood flow.

  • New-onset hypertension and proteinuria indicate preeclampsia; absence of proteinuria does not exclude preeclampsia.

  • Evaluate patients for DVT if they have unilateral leg edema, redness, warmth, and tenderness.

  • Evaluate patients for peripartum cardiomyopathy if they have dyspnea and if the physical examination detects evidence of fluid overload.

  • Because preeclampsia significantly increases the risk of peripartum cardiomyopathy, rapidly evaluate patients who have preeclampsia and possible cardiac dysfunction and/or pulmonary edema for peripartum cardiomyopathy.

Drugs Mentioned In This Article

Drug Name Select Trade
Aluvea , BP-50% Urea , BP-K50, Carmol, CEM-Urea, Cerovel, DermacinRx Urea, Epimide-50, Gord Urea, Gordons Urea, Hydro 35 , Hydro 40, Kerafoam, Kerafoam 42, Keralac, Keralac Nailstik, Keratol, Keratol Plus, Kerol, Kerol AD, Kerol ZX, Latrix, Mectalyte, Nutraplus, RE Urea 40, RE Urea 50 , Rea Lo, Remeven, RE-U40, RYNODERM , U40, U-Kera, Ultra Mide 25, Ultralytic-2, Umecta, Umecta Nail Film, URALISS, Uramaxin , Uramaxin GT, Urea, Ureacin-10, Ureacin-20, Urealac , Ureaphil, Uredeb, URE-K , Uremez-40, Ure-Na, Uresol, Utopic, Vanamide, Xurea, X-VIATE
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NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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