The genus Shigella is distributed worldwide and is the typical cause of inflammatory dysentery, responsible for 5 to 10% of diarrheal illness in many areas. Shigella is divided into 4 major subgroups:
A (S. dysenteriae)
B (S. flexneri)
C (S. boydii)
D (S. sonnei)
Each subgroup is further subdivided into serologically determined types. S. flexneri and S. sonnei are more widespread than S. boydii and the particularly virulent S. dysenteriae. S. sonnei is the most common isolate in the US.
The source of infection is the feces of infected people or convalescent carriers; humans are the only natural reservoir for Shigella. Direct spread is by the fecal-oral route. Indirect spread is by contaminated food and fomites. Flies serve as vectors.
Because Shigella are relatively resistant to gastric acid, ingestion of as few as 10 to 100 organisms can cause disease. Epidemics occur most frequently in overcrowded populations with inadequate sanitation. Shigellosis is particularly common among younger children living in endemic areas. Adults usually have less severe disease.
Convalescents and subclinical carriers may be significant sources of infection, but true long-term carriers are rare.
An episode of shigellosis imparts serotype-specific immunity for at least several years. But patients may have additional episodes of shigellosis caused by other serotypes.
Shigella organisms penetrate the mucosa of the colon, causing mucus secretion, hyperemia, leukocytic infiltration, edema, and often superficial mucosal ulcerations. Shigella dysenteriae type 1 (not commonly present in the US, except in travelers returning from endemic areas) produces Shiga toxin, which causes marked watery diarrhea and sometimes hemolytic-uremic syndrome Thrombotic Thrombocytopenic Purpura (TTP) Thrombotic thrombocytopenic purpura (TTP) is an acute, fulminant disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia. Other manifestations may include alterations... read more .
Symptoms and Signs of Shigellosis
The incubation period for Shigella is 1 to 4 days. The most common presentation, watery diarrhea, is indistinguishable from other bacterial, viral, and protozoan infections that induce secretory activity of intestinal epithelial cells. Fever may be present.
In adults, initial symptoms of shigellosis may be
Episodes of gripping abdominal pain
Urgency to defecate (tenesmus)
Passage of formed feces that temporarily relieves the pain
These episodes recur with increasing severity and frequency. Diarrhea becomes marked, with soft or liquid stools containing mucus, pus, and often blood. Rectal prolapse and consequent fecal incontinence may result from severe tenesmus.
However, adults may present without fever, with nonbloody and nonmucoid diarrhea, and with little or no tenesmus.
The disease usually resolves spontaneously in adults—mild cases in 4 to 8 days, severe cases in 3 to 6 weeks. Significant dehydration and electrolyte loss with circulatory collapse and death occur mainly in debilitated adults and children < 2 years.
Rarely, shigellosis starts suddenly with rice-water or serous (occasionally bloody) stools. The patient may vomit and rapidly become dehydrated. Infection may manifest as delirium, seizures, and coma but with little or no diarrhea. Death may occur in 12 to 24 hours.
In young children, onset is sudden, with fever, irritability or drowsiness, anorexia, nausea or vomiting, diarrhea, abdominal pain and distention, and tenesmus. Within 3 days, blood, pus, and mucus appear in the stools. The number of stools may increase to ≥ 20/day, and weight loss and dehydration become severe. If untreated, children may die in the first 12 days. If children survive, acute symptoms subside by the 2nd week.
Hemolytic-uremic syndrome Thrombotic Thrombocytopenic Purpura (TTP) Thrombotic thrombocytopenic purpura (TTP) is an acute, fulminant disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia. Other manifestations may include alterations... read more (HUS) may complicate shigellosis due to S. dysenteriae type 1 in children. HUS, if it occurs, develops about 7 days (but up to 3 weeks) after the first symptoms of shigellosis, when the diarrhea is resolving. HUS is signaled by the development of lethargy and decreasing urine output.
Bacteremia may occur, especially in children under 5 years of age and in adults over 65 with underlying disease.
Severe mucosal ulcerations may cause significant acute blood loss.
Patients (particularly those with the human leukocyte antigen [HLA]-B27 genotype) may develop reactive arthritis Reactive Arthritis Reactive arthritis is an acute spondyloarthropathy that often seems precipitated by an infection, usually genitourinary or gastrointestinal. Common manifestations include asymmetric arthritis... read more (arthritis, conjunctivitis, urethritis) after shigellosis (and other enteritides).
Other complications are uncommon but include seizures in children, myocarditis, and, rarely, intestinal perforation.
Infection does not become chronic and is not an etiologic factor in ulcerative colitis.
Diagnosis of Shigellosis
Polymerase chain reaction (PCR) testing
Diagnosis of shigellosis is facilitated by a high index of suspicion during outbreaks and in endemic areas and by the presence of fecal leukocytes on smears stained with methylene blue or Wright stain. Stool cultures are diagnostic and should be obtained; for severely ill or at-risk patients, antimicrobial sensitivity testing is done. PCR testing is also available.
In patients with symptoms of dysentery (bloody and mucoid stools), the differential diagnosis should include enterohemorrhagic E. coli Infection by Escherichia coli O157:H7 and Other Enterohemorrhagic E. coli (EHEC) The gram-negative bacteria Escherichia coli O157:H7 and other enterohemorrhagic E. coli (EHEC) typically cause acute bloody diarrhea, which may lead to hemolytic-uremic syndrome... read more , Salmonella Overview of Salmonella Infections The genus Salmonella is divided into 2 species, S. enterica and S. bongori, which include > 2500 known serotypes. Some of these serotypes are named. In such cases, common... read more , Yersinia Plague and Other Yersinia Infections Plague is caused by the gram-negative bacterium Yersinia pestis. Symptoms are either severe pneumonia or large, tender lymphadenopathy with high fever, often progressing to septicemia... read more , and Campylobacter Campylobacter and Related Infections Campylobacter infections typically cause self-limited diarrhea but occasionally cause bacteremia, with consequent endocarditis, osteomyelitis, or septic arthritis. Diagnosis is by culture... read more infections; amebiasis Amebiasis Amebiasis is infection with Entamoeba histolytica. It is acquired by fecal-oral transmission. Infection is commonly asymptomatic, but symptoms ranging from mild diarrhea to severe dysentery... read more ; and Clostridioides difficile infection Clostridioides (formerly Clostridium) difficile–Induced Diarrhea Toxins produced by Clostridioides difficile strains in the gastrointestinal tract cause pseudomembranous colitis, typically after antibiotic use. Symptoms are diarrhea, sometimes bloody... read more .
The mucosal surface, as seen through a proctoscope, is diffusely erythematous with numerous small ulcers. Although leukopenia or marked leukocytosis may be present, white blood cell count averages 13,000/mcL (13 × 109/L). Hemoconcentration is common, as is diarrhea-induced metabolic acidosis.
Treatment of Shigellosis
For severely ill or at-risk patients, a fluoroquinolone, azithromycin, or a 3rd-generation cephalosporin
Fluid loss due to shigellosis is treated symptomatically with oral or IV fluids Intravenous Fluid Resuscitation Almost all circulatory shock states require large-volume IV fluid replacement, as does severe intravascular volume depletion (eg, due to diarrhea or heatstroke). Intravascular volume deficiency... read more .
Antidiarrheal drugs (eg, loperamide) may prolong illness and should not be used.
Antibiotics can reduce the symptoms and shedding of Shigella but are not necessary for healthy adults with mild illness. However, certain patients, including the following, should usually be treated:
Patients with moderate to severe disease
For adults, the following antibiotic regimens may be used:
A fluoroquinolone (such as ciprofloxacin 500 mg orally every 12 hours for 3 to 5 days)
Azithromycin 500 mg orally on day 1 and 250 mg once a day for 4 days
Ceftriaxone 2 g/day IV for 5 days
For children, the following antibiotic regimens may be used:
Ceftriaxone 50 mg/kg (maximum 1.5 g) IV once a day for 5 days
Azithromycin 10 to 12 mg/kg orally as a single dose on day 1, followed by 6 mg/kg (maximum 250 mg) once a day for 4 days
Many Shigella isolates are likely to be resistant to ampicillin, trimethoprim/sulfamethoxazole (TMP/SMX), and tetracyclines, but patterns of resistance vary by geographic region.
Prevention of Shigellosis
Hands should be washed thoroughly before handling food. Soiled garments and bedclothes should be immersed in covered buckets of soap, water, and disinfectant until they can be washed in hot water. Appropriate isolation techniques (especially stool isolation) should be used with patients and carriers.
A live oral vaccine is being developed, and field trials in endemic areas hold promise. However, immunity is generally type specific so presumably the vaccine would need to be polyvalent or contain an antigen common to multiple serotypes.
Shigella species are a highly contagious cause of dysentery; humans are the only reservoir.
Watery diarrhea may be accompanied by abdominal pain and marked urgency to defecate; stools may contain mucus, pus, and often blood.
S. dysenteriae type 1 (not common in the US, except in returning travelers) produces Shiga toxin, which may cause hemolytic-uremic syndrome.
Significant dehydration and electrolyte loss with circulatory collapse and death occur mainly in debilitated adults and children < 2 years.
Supportive care is usually adequate, but give antibiotics (a fluoroquinolone, azithromycin, ceftriaxone) to young children and to older, debilitated, or severely ill patients; resistance to ampicillin, trimethoprim/sulfamethoxazole (TMP/SMX), and tetracyclines is common.
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