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Varicella Vaccine


Margot L. Savoy

, MD, MPH, Lewis Katz School of Medicine at Temple University

Reviewed/Revised Jul 2023

Varicella vaccination provides effective protection against varicella Chickenpox Chickenpox is an acute, systemic, usually childhood infection caused by the varicella-zoster virus (human herpesvirus type 3). It usually begins with mild constitutional symptoms (eg, fever... read more Chickenpox (chickenpox). It is not known how long protection against varicella lasts. But, live-virus vaccines, like the varicella vaccine, usually provide long-lasting immunity.

Preparations of Varicella Vaccine

The varicella vaccine contains an attenuated wild strain of varicella and trace amounts of gelatin and neomycin. It is available as a single-antigen vaccine or as a combination vaccine with measles, mumps, rubella Measles, Mumps, and Rubella (MMR) Vaccine The measles/mumps/rubella vaccines (MMR vaccines) effectively protect against all 3 infections ( measles, mumps, rubella). Historically, people who are given the MMR vaccine according to the... read more (MMRV).

Indications of Varicella Vaccine

Varicella vaccine is a routine childhood vaccine (see CDC: Child and Adolescent Immunization Schedule by Age).

Single-antigen varicella vaccine also is recommended for all people ≥ 13 years who do not have evidence of immunity to varicella (see CDC: Adult Immunization Schedule by Age.)

Evidence of immunity consists of one of the following:

  • Documentation of 2 doses of varicella vaccine given ≥ 4 weeks apart

  • History of varicella or herpes zoster verified by a health care professional

  • Laboratory confirmation of protective levels of varicella antibodies

  • Birth in the United States before 1980, except for health care workers and pregnant women

The varicella vaccine is recommended particularly for people who do not have evidence of immunity and are likely to be exposed to or transmit varicella, including the following:

  • Health care workers

  • Household contacts of immunocompromised people

  • People who live or work in places where exposure or transmission is likely (eg, teachers, students, child care workers, residents and employes of institutional settings, inmates and employees of correctional institutions, military personnel)

  • Women of childbearing age who are not pregnant

  • Adolescents and adults living in households with children

  • International travelers

Postexposure vaccination with the single-antigen varicella vaccine is recommended for children with no evidence of immunity and should be offered to adults with no evidence of immunity. The vaccine is effective in preventing or ameliorating disease if it is given within 3 days and possibly up to 5 days after exposure; however, the vaccine should be given as soon as possible. If exposure to varicella does not cause infection, postexposure vaccination should induce protection against subsequent exposures, even if the vaccine is given > 5 days postexposure.

Varicella-zoster immune globulin (see table ) is recommended for postexposure prophylaxis in people who have no evidence of immunity, are at increased risk of severe varicella, and/or have contraindications to the varicella vaccine. These people include

  • Immunocompromised people without evidence of immunity

  • Pregnant women without evidence of immunity

  • Neonates whose mothers developed varicella within 5 days before to 2 days after delivery

  • Hospitalized premature infants who were born at ≥ 28 weeks gestation and whose mothers do not have evidence of immunity to varicella

  • Hospitalized premature infants who were born at < 28 weeks gestation or who weigh ≤ 1000 g at birth, regardless of their mother's evidence of immunity to varicella

Contraindications and Precautions for Varicella Vaccine

Contraindications for varicella vaccine include

The single-antigen varicella vaccine may be given to children aged 1 to 8 years who have HIV infection if their CD4 percentage is ≥ 15; it may be given to those > 8 years if their CD4 percentage is ≥ 15 and CD4 count is ≥ 200/mcL with no evidence of immunity.

Precautions with varicella vaccine include

  • Moderate or severe acute illness with or without fever (vaccination is postponed until illness resolves)

  • Recent (within 11 months) treatment with blood products that contain antibody (specific interval depends on the product)

  • Use of specific antiviral drugs: acyclovir, famciclovir, or valacyclovir (if possible, these drugs are stopped 24 hours before vaccination and are not resumed for 14 days after vaccination)

Breastfeeding is not a contraindication to vaccination. Women who are breastfeeding and do not have evidence of immunity can be vaccinated postpartum and continue breastfeeding.

Dose and Administration of Varicella Vaccine

The varicella vaccine dose is 0.5 mL given subcutaneously in 2 doses: at age 12 to 15 months and at age 4 to 6 years. If children, adolescents, or adults have been given only 1 dose, a catch-up dose is recommended. The recommended minimum interval between the first dose and the catch-up second dose is 3 months for children aged ≤ 12 years and 4 weeks for people aged ≥ 13 years; the second dose may be given at any interval longer than the minimum.

If adults think that they have not had varicella or are likely to be exposed to or to transmit varicella, levels of protective antibodies should be measured to check for evidence of immunity and thus determine the need for vaccination.

No immune globulins, particularly varicella-zoster immune globulin, should be given within 5 months before or 2 months after vaccination because immune globulins may prevent development of protective antibodies.

Eligible children with HIV infection are given 2 doses of single-antigen varicella vaccine 3 months apart. Because impaired cellular immunity increases the risk of complications after vaccination with a live vaccine, these children should be encouraged to return for evaluation if a varicella-like rash develops after vaccination.

Prenatal assessment of women for evidence of varicella immunity is indicated. Birth before 1980 is not considered evidence of immunity for pregnant women. After completion or termination of pregnancy, women who do not have evidence of immunity should be given the first dose of vaccine before discharge and the second dose 4 to 8 weeks later, usually at the postpartum visit. Women should be advised to avoid becoming pregnant for 1 month after each dose.

Adverse Effects of Varicella Vaccine

Most adverse effects are minimal and include transient pain, tenderness, and redness at the injection site. Occasionally, within 1 month of vaccination, a mild maculopapular or varicella-like rash develops in 1 to 3% of people who are vaccinated. Vaccine recipients who develop this rash should diligently avoid contact with immunocompromised people until it resolves. Spread of the virus from vaccine recipients to susceptible people is rare but can result in severe problems, including pneumonia, hepatitis, severe rash, and shingles with meningitis. However, such problems rarely develop.

More Information

The following English-language resources may be useful. Please note that THE MANUAL is not responsible for the content of these resources.

Drugs Mentioned In This Article

Drug Name Select Trade
Sitavig, Zovirax, Zovirax Cream, Zovirax Ointment, Zovirax Powder, Zovirax Suspension
NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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