Parasitic Brain Infections
In some parts of the world, brain infections may be due to worms or other parasites. These infections are more common in developing countries and rural areas. They are less common in the United States.
(See also Overview of Brain Infections.)
Neurocysticercosis is caused by pork tapeworm larvae. Of all the worms that cause brain infections, the pork tapeworm causes by far the most cases of brain infections in the Western Hemisphere.
After people eat food contaminated with the tapeworm's eggs, secretions in the stomach cause the eggs to hatch into larvae. The larvae enter the bloodstream and are distributed to all parts of the body, including the brain and spinal cord. The larvae form cysts (clusters of larvae enclosed in a protective wall). (The infection caused by cysts is called cysticercosis or, when the cysts form in the brain, neurocysticercosis.) These cysts cause few symptoms until the cysts degenerate and the larvae die, triggering inflammation, swelling, and symptoms such as headaches, seizures, personality changes, and mental impairment.
Sometimes the cysts block the flow of cerebrospinal fluid within the spaces of the brain (ventricles) putting pressure on the brain. This disorder is called hydrocephalus. The increased pressure can cause headaches, nausea, vomiting, and sleepiness.
Cysts may rupture and spill their contents into the cerebrospinal fluid, causing meningitis.
Without treatment, people with neurocysticercosis may die.
Doctors suspect neurocysticercosis in people who live in or have come from developing countries and who have typical symptoms. Magnetic resonance imaging (MRI) or computed tomography (CT) can often show the cysts. But blood tests and a spinal tap (lumbar puncture) to obtain a sample of cerebrospinal fluid are often needed to confirm the diagnosis. Occasionally, a biopsy of the cyst is needed.
The infection is treated with albendazole or praziquantel (drugs used to treat parasitic worm infections, called antihelminthic drugs). Corticosteroids are given to reduce the inflammation that occurs as the larvae die. Seizures are treated with antiseizure drugs.
Occasionally, surgery is necessary to place a drain (shunt) to remove the excess cerebrospinal fluid and relieve the hydrocephalus. The shunt is a piece of plastic tubing placed in the spaces within the brain. The tubing is run under the skin, usually to the abdomen, where excess fluid can drain. Surgery to remove cysts from the brain may also be needed.
Echinococcosis (hydatid disease) and coenurosis are infections with other types of tapeworm larvae. Echinococcosis can produce large cysts in the brain. Coenurosis, like cysticercosis, produces cysts that can block the flow of fluid around the brain.
Schistosomiasis is an infection caused by blood flukes. In some people with schistosomiasis, inflamed clumps of cells (granulomas) develop in the brain.
Echinococcosis, coenurosis, and schistosomiasis can cause symptoms similar to those of cysticercosis, including seizures, headaches, personality changes, and mental impairment. Symptoms caused by echinococcosis or coenurosis may take years to develop.
Doctors can usually diagnose these infections based on results from MRI or CT, but sometimes a spinal tap is needed. The spinal fluid may have a large number of white blood cells called eosinophils.
These three infections are usually treated with antihelminthic drugs, such as albendazole, mebendazole, praziquantel, and pyrantel pamoate. But in echinococcosis and coenurosis, cysts must often be removed surgically.